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Recombinant Mouse Ascl2 Protein, Myc/DDK-tagged

Cat.No. : Ascl2-1740M
Product Overview : Purified recombinant protein of mouse full-length achaete-scute family bHLH transcription factor 2 (Ascl2), with C-terminal MYC/DDK tag, expressed in HEK293T cells.
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Description : AS-C proteins are involved in the determination of the neuronal precursors in the peripheral nervous system and the central nervous system.
Source : HEK293T
Species : Mouse
Tag : Myc/DDK
Molecular Mass : 28.2 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Storage : Store at -80 centigrade after receiving vials.
Concentration : >50 μg/mL as determined by microplate BCA method
Storage Buffer : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Gene Name : Ascl2 achaete-scute family bHLH transcription factor 2 [ Mus musculus (house mouse) ]
Official Symbol : Ascl2
Synonyms : ASCL2; achaete-scute complex homolog 2 (Drosophila); achaete-scute homolog 2; ASH-2; mASH-2; mammalian achaete scute homolog 2; achaete-scute complex homolog-like 2; long transient receptor potential-related channel 5; Mash2; bHLHa45; 2410083I15Rik
Gene ID : 17173
mRNA Refseq : NM_008554
Protein Refseq : NP_032580
UniProt ID : O35885

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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Can ASCL2 induce pluripotency or cellular reprogramming? 01/12/2023

ASCL2, along with other transcription factors and signaling molecules, has been used in combination to induce cellular reprogramming and pluripotency in certain contexts, demonstrating its ability to alter cell fate.

Does ASCL2 have any role in other tissues or organs? 01/10/2023

ASCL2's primary role is in the gastrointestinal tract, but it may also have roles in other tissues and organs during development, including lung and pancreas.

Are there any known interacting partners of ASCL2? 09/30/2019

ASCL2 interacts with various co-factors and proteins involved in stem cell regulation and development, including β-catenin, POU5F1 (Oct4), and SMAD proteins.

Is ASCL2 essential for the development of the gastrointestinal tract? 06/14/2019

Yes, ASCL2 is crucial for the normal development of the gastrointestinal tract, particularly in regulating the differentiation and proliferation of intestinal stem cells.

Can ASCL2 be targeted for therapeutic interventions or drug discovery? 04/06/2017

ASCL2 is being explored as a potential therapeutic target for colorectal cancer due to its involvement in promoting abnormal cell proliferation. Targeting ASCL2 may help inhibit tumor growth and progression.

How does ASCL2 regulate intestinal stem cells? 02/17/2016

ASCL2 promotes the self-renewal of intestinal stem cells by activating specific gene expression programs involved in stem cell maintenance. It also regulates the balance between proliferation and differentiation of these cells.

Customer Reviews (3)

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Reviews
06/08/2022

    The manufacturer's commitment to providing excellent technical support is highly valuable.

    05/02/2018

      The combination of high-quality ASCL2 protein and excellent technical support provided by the manufacturer makes them the ideal choice for my research.

      07/15/2017

        The ASCL2 protein offered by the manufacturer is of exceptional quality, and it meets the rigorous standards necessary for my experimental needs.

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