Active Recombinant Mouse BACE2 Protein, His-Tagged
Cat.No. : | BACE2-33M |
Product Overview : | Recombinant mouse BACE2 (Q9JL18) (Met1-Pro462) was expressed with a C-terminal polyhistidine tag. |
- Specification
- Gene Information
- Related Products
Description : | BACE2, also known as beta secretase 2, belongs to the peptidase A1 family. It is a protease known to be an important enzyme involved in the cellular pathways. BACE2 has been shown to interact with GGA1 and GGA2. It is the major β-secretase in vivo. BACE2 is located on chromosome 21 and may play a role in alzheimer's disease pathogenesis in down syndrome(DS). Overexpression of BACE2 by lentivirus markedly reduced amyloid β protein production in primary neurons. Despite an extra copy of the BACE2 gene in DS and the increase of its transcription, BACE2 protein levels are unchanged. |
Source : | HEK293 |
Species : | Mouse |
Tag : | His |
Form : | Sterile PBS, pH 7.4 |
Bio-activity : | Measured by its ability to cleave a fluorogenic peptide substrate Mca-KPLGL-Dpa-AR-NH2. The specific activity is >50 pmoles/min/μg. |
Molecular Mass : | The recombinant mouse BACE2 comprises 454 amino acids and has a predicted molecular mass of 49.2 kDa. The apparent molecular mass of the protein is approximately 55 kDa in SDS-PAGE under reducing conditions due to glycosylation. |
Endotoxin : | < 1.0 EU per μg of the protein as determined by the LAL method |
Purity : | > 95 % as determined by SDS-PAGE |
Storage : | Store it under sterile conditions at -20 centigrade to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
Gene Name : | Bace2 beta-site APP-cleaving enzyme 2 [ Mus musculus (house mouse) ] |
Official Symbol : | Bace2 |
Synonyms : | ARP1; ASP1; BAE2; DRAP; AEPLC; ALP56; ASP21; CDA13; CEAP1; AI850424; 1110059C24Rik |
Gene ID : | 56175 |
mRNA Refseq : | NM_019517.5 |
Protein Refseq : | NP_062390.3 |
UniProt ID : | Q9JL18 |
Products Types
◆ Recombinant Protein | ||
BACE2-588R | Recombinant Rat BACE2 Protein, His (Fc)-Avi-tagged | +Inquiry |
Bace2-11M | Active Recombinant Mouse Bace2 Protein (20-462aa), C-His-tagged | +Inquiry |
Bace2-1816M | Recombinant Mouse Bace2 Protein, Myc/DDK-tagged | +Inquiry |
Bace2-947M | Recombinant Mouse Bace2 Protein, His (Fc)-Avi-tagged | +Inquiry |
BACE2-1831H | Recombinant Human BACE2 protein, His-tagged | +Inquiry |
◆ Lysates | ||
BACE2-1388MCL | Recombinant Mouse BACE2 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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