Recombinant Mouse Becn1 Protein, Myc/DDK-tagged

• Cat.No.: Becn1-1855M
• Product Overview: Purified recombinant protein of mouse full-length beclin 1, autophagy related (Becn1), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: Plays a central role in autophagy. Acts as core subunit of different PI3K complex forms that mediate formation of phosphatidylinositol 3-phosphate and are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2. Essential for the formation of PI3KC3-C2 but not PI3KC3-C1 PI3K complex forms. Involved in endocytosis including endosome formation in neuronal cells. May play a role in antiviral host defense.
• Source: HEK293T
• Species: Mouse
• Tag: Myc/DDK
• Molecular Mass: 52 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Becn1 beclin 1, autophagy related [ Mus musculus (house mouse) ]
• Official Symbol: Becn1
• Synonyms: BECN1; beclin 1, autophagy related; beclin-1; Bcl-2-interacting protein beclin; coiled-coil myosin-like BCL2-interacting protein; coiled-coil, myosin-like BCL2-interacting protein; Atg6; MGC6843; 4921513J16Rik; 5430417M23Rik
• Gene ID: 56208
• mRNA Refseq: NM_019584
• Protein Refseq: NP_062530
• UniProt ID: O88597