Recombinant Mouse C1qb Protein, MYC/DDK-tagged
Cat.No. : | C1qb-730M |
Product Overview : | Purified recombinant protein of full-length mouse complement component 1, q subcomponent, beta polypeptide (C1qb), with C-terminal MYC/DDK tag, expressed in HEK293T cells. |
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- Gene Information
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Description : | C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes. |
Source : | HEK293T |
Species : | Mouse |
Tag : | MYC/DDK |
Molecular Mass : | 26.7 kDa |
Purity : | >80% as determined by SDS-PAGE and Coomassie blue staining |
Stability : | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
Storage : | Store at -80 centigrade after receiving vials. |
Concentration : | >50 μg/mL as determined by microplate BCA method |
Storage Buffer : | 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol. |
Gene Name : | C1qb complement component 1, q subcomponent, beta polypeptide [ Mus musculus (house mouse) ] |
Official Symbol : | C1qb |
Synonyms : | C1qb; complement component 1, q subcomponent, beta polypeptide; Adia; complement C1q subcomponent subunit B; adiponectin a |
Gene ID : | 12260 |
mRNA Refseq : | NM_009777 |
Protein Refseq : | NP_033907 |
UniProt ID : | P14106 |
Products Types
◆ Recombinant Protein | ||
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C1QB-464H | Recombinant Human C1QB Protein, His (Fc)-Avi-tagged | +Inquiry |
C1QB-1042R | Recombinant Rat C1QB Protein | +Inquiry |
C1QB-596H | Recombinant Human C1QB, His tagged | +Inquiry |
◆ Lysates | ||
C1QB-651HCL | Recombinant Human C1QB cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (7)
Ask a questionC1QB, as part of C1q, plays a role in opsonization by marking pathogens and immune complexes for phagocytosis after binding and activating the complement system.
C1QB is one of the chains (together with C1QA and C1QC) that forms the C1q molecule, which is the first component of the classical pathway of the complement system, playing a crucial role in innate immunity.
Given the role of C1QB in the complement system and its association with autoimmune diseases, targeting C1QB or its interactions might be a therapeutic strategy for conditions like SLE or other complement-mediated diseases.
C1QB, as a part of the C1q molecule, plays a significant role in recognizing and binding to immune complexes, apoptotic cells, and certain pathogens, thereby activating the classical complement pathway and facilitating their clearance.
Once C1q (comprising C1QA, C1QB, and C1QC) binds to immune complexes, it triggers the binding and autoactivation of C1r and C1s serine proteases, forming the active C1 complex and initiating the classical complement cascade.
C1q is a hexamer formed by the association of six C1qA, six C1qB, and six C1qC chains. C1QB contributes to this hexameric structure, which is essential for the recognition of immune complexes.
Mutations in the C1QB gene can lead to C1q deficiency, which is associated with an increased risk of systemic lupus erythematosus (SLE) and other autoimmune diseases.
Customer Reviews (3)
Write a reviewProduct is worth the price.
Outstanding performance in experiments.
Excellent for biochemical assays.
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