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Recombinant Mouse C1qb Protein, MYC/DDK-tagged

Cat.No. : C1qb-730M
Product Overview : Purified recombinant protein of full-length mouse complement component 1, q subcomponent, beta polypeptide (C1qb), with C-terminal MYC/DDK tag, expressed in HEK293T cells.
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Description : C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes.
Source : HEK293T
Species : Mouse
Tag : MYC/DDK
Molecular Mass : 26.7 kDa
Purity : >80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Storage : Store at -80 centigrade after receiving vials.
Concentration : >50 μg/mL as determined by microplate BCA method
Storage Buffer : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Gene Name : C1qb complement component 1, q subcomponent, beta polypeptide [ Mus musculus (house mouse) ]
Official Symbol : C1qb
Synonyms : C1qb; complement component 1, q subcomponent, beta polypeptide; Adia; complement C1q subcomponent subunit B; adiponectin a
Gene ID : 12260
mRNA Refseq : NM_009777
Protein Refseq : NP_033907
UniProt ID : P14106

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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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What role does C1QB play in opsonization? 04/08/2022

C1QB, as part of C1q, plays a role in opsonization by marking pathogens and immune complexes for phagocytosis after binding and activating the complement system.

What is the primary function of the C1QB protein in the complement system? 10/26/2021

C1QB is one of the chains (together with C1QA and C1QC) that forms the C1q molecule, which is the first component of the classical pathway of the complement system, playing a crucial role in innate immunity.

Are there any therapeutic implications related to targeting C1QB in diseases? 08/13/2020

Given the role of C1QB in the complement system and its association with autoimmune diseases, targeting C1QB or its interactions might be a therapeutic strategy for conditions like SLE or other complement-mediated diseases.

What is the significance of C1QB in immune responses? 06/01/2020

C1QB, as a part of the C1q molecule, plays a significant role in recognizing and binding to immune complexes, apoptotic cells, and certain pathogens, thereby activating the classical complement pathway and facilitating their clearance.

How does C1QB interact with other components of the complement system? 11/08/2019

Once C1q (comprising C1QA, C1QB, and C1QC) binds to immune complexes, it triggers the binding and autoactivation of C1r and C1s serine proteases, forming the active C1 complex and initiating the classical complement cascade.

How does C1QB contribute to the formation of the C1 complex? 11/04/2019

C1q is a hexamer formed by the association of six C1qA, six C1qB, and six C1qC chains. C1QB contributes to this hexameric structure, which is essential for the recognition of immune complexes.

Are there any known genetic mutations in the C1QB gene associated with diseases? 05/05/2018

Mutations in the C1QB gene can lead to C1q deficiency, which is associated with an increased risk of systemic lupus erythematosus (SLE) and other autoimmune diseases.

Customer Reviews (3)

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Reviews
02/13/2022

    Product is worth the price.

    09/09/2019

      Outstanding performance in experiments.

      04/03/2019

        Excellent for biochemical assays.

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