Recombinant Mouse Cd28 protein, His-tagged
Cat.No. : | Cd28-4008M |
Product Overview : | Recombinant Mouse Cd28 (Asn20-Lys149) protein was fused to His-tag at C-terminus and expressed in human 293 cells (HEK293). |
Availability | October 14, 2024 |
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Description : | T-cell-specific surface glycoprotein CD28 is also known as TP44, is a single-pass type I membrane protein which contains one Ig-like V-type (immunoglobulin-like) domain. is one of the molecules expressed on T cells that provide co-stimulatory signals, which are required for T cell activation. CD28 is the receptor for CD80 (B7.1) and CD86 (B7.2). When activated by Toll-like receptor ligands, the CD80 expression is upregulated in antigen presenting cells (APCs). The CD86 expression on antigen presenting cells is constitutive. CD28 is the only B7 receptor constitutively expressed on naive T cells. |
Source : | HEK293 |
Species : | Mouse |
Tag : | His |
Predicted N Terminal : | Asn20 |
Form : | Lyophilized from 0.22 μm filtered solution in PBS, pH7.4, 10% trehalose. |
Molecular Mass : | The protein has a calculated MW of 16.9 kDa. The protein migrates as 30-35 kDa and 55 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation. |
Protein length : | Asn20-Lys149 |
Endotoxin : | Less than 1.0 EU per μg by the LAL method. |
Purity : | >90% as determined by SDS-PAGE. |
Storage : | For long term storage, the product should be stored at lyophilized state at -20 centigrade or lower. Please avoid repeated freeze-thaw cycles. This product is stable after storage at: -20 to -70 centigrade for 12 months in lyophilized state; -70 centigrade for 3 months under sterile conditions after reconstitution. |
Reconstitution : | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4℃ before opening to recover the entire contents. |
Gene Name : | Cd28 |
Official Symbol : | Cd28 |
Synonyms : | CD28; CD28 antigen; T-cell-specific surface glycoprotein CD28 |
Gene ID : | 12487 |
mRNA Refseq : | NM_007642 |
Protein Refseq : | NP_031668 |
UniProt ID : | P31041 |
Products Types
◆ Recombinant Protein | ||
CD28-1056H | Recombinant Human/Cynomolgus/Rhesus CD28 protein(Met1-Pro152), His&Avi-tagged, Biotinylated | +Inquiry |
CD28-668H | Recombinant Human CD28 Protein, His&SUMO-tagged | +Inquiry |
Cd28-666M | Recombinant Mouse Cd28 Protein, His-tagged | +Inquiry |
CD28-624M | Recombinant Mouse CD28 Protein | +Inquiry |
Cd28-669R | Recombinant Rat Cd28 Protein, His-tagged | +Inquiry |
◆ Lysates | ||
CD28-2002MCL | Recombinant Mouse CD28 cell lysate | +Inquiry |
CD28-2013HCL | Recombinant Human CD28 cell lysate | +Inquiry |
◆ Assay kits | ||
Kit-1705 | CD28:B7-1[Biotinylated] Inhibitor Screening Assay Kit | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Customer Reviews (3)
Write a reviewIts unique characteristics contribute to obtaining clear and detailed structural information, enabling researchers to unravel the intricate complexities of protein interactions and conformational changes.
Researchers can confidently rely on its capabilities to generate precise and significant results, enhancing the understanding of protein function and dynamics.
the CD28 protein's outstanding performance in ELISA and its utility in protein electron microscopy structure analysis make it a highly recommended tool for researchers.
Q&As (5)
Ask a questionCD28 protein expression and function may be relevant for personalized treatment strategies in autoimmune diseases and cancer.
Targeting CD28 protein may have therapeutic potential in treating autoimmune diseases, cancer immunotherapy, and organ transplantation.
CD28 signaling is important for the function and maintenance of regulatory T cells, which play a role in immune tolerance and suppression of autoimmunity.
CD28 protein is involved in enhancing the anti-tumor immune response, making it a potential target for cancer immunotherapy.
Currently, there are no FDA-approved therapies specifically targeting CD28 protein, but research is ongoing in this area.
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