Recombinant Mouse Cdc20 Protein, MYC/DDK-tagged Cdc20-352M

Recombinant Mouse Cdc20 Protein, MYC/DDK-tagged

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Recombinant Mouse Cdc20 Protein, MYC/DDK-tagged

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Cat.No. : Cdc20-352M
Product Overview : Purified recombinant protein of full-length mouse cell division cycle 20 (Cdc20), with C-terminal MYC/DDK tag, expressed in HEK293T cells.
Description : Required for full ubiquitin ligase activity of the anaphase promoting complex/cyclosome (APC/C) and may confer substrate specificity upon the complex. Is regulated by MAD2L1: in metaphase the MAD2L1-CDC20-APC/C ternary complex is inactive and in anaphase the CDC20-APC/C binary complex is active in degrading substrates. The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. CDC20-APC/C-induced degradation of NEUROD2 induces presynaptic differentiation.
Source : HEK293T
Species : Mouse
Tag : MYC/DDK
Molecular Mass : 54.8 kDa
Purity : >80%, as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Storage : Store at -80 centigrade after receiving vials.
Concentration : >50 ug/mL as determined by microplate BCA method
Storage Buffer : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Gene Name : Cdc20 cell division cycle 20 [ Mus musculus (house mouse) ]
Official Symbol : Cdc20
Synonyms : Cdc20; cell division cycle 20; C87100; p55CDC; 2310042N09Rik; cell division cycle protein 20 homolog; cell division cycle 20 homolog; mmCdc20
Gene ID : 107995
mRNA Refseq : NM_023223
Protein Refseq : NP_075712
UniProt ID : Q9JJ66

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