Recombinant Mouse Cldn4 Protein, MYC/DDK-tagged

• Cat.No.: Cldn4-901M
• Product Overview: Purified recombinant protein of full-length mouse claudin 4 (Cldn4), with C-terminal MYC/DDK tag, was expressed in HEK293T cells.

Specification

• Description: This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. The protein encoded by this gene is a high-affinity receptor for clostridium perfringens enterotoxin (CPE) produced by the bacterium Clostridium perfringens, and the interaction with CPE results in increased membrane permeability by forming small pores in plasma membrane. This protein augments alveolar epithelial barrier function and is induced in acute lung injury. It is highly expressed in pancreatic and ovarian cancers.
• Source: HEK293T
• Species: Mouse
• Tag: MYC/DDK
• Molecular Mass: 22.3 kDa
• Purity: >80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 µg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Cldn4 claudin 4 [ Mus musculus (house mouse) ]
• Official Symbol: Cldn4
• Synonyms: Cldn4; claudin 4; Cep-r; Cpetr; Cpetr1; claudin-4; CPE-R; CPE-receptor; clostridium perfringens enterotoxin receptor
• Gene ID: 12740
• mRNA Refseq: NM_009903
• Protein Refseq: NP_034033
• UniProt ID: O35054

Reviews

08/05/2021

The CLDN4 protein showcases outstanding quality, ensuring its suitability for addressing my experimental requirements effectively.

06/02/2019

the manufacturer's dedication to excellent technical support assures me that any challenges or obstacles I encounter will be swiftly resolved.

06/25/2016

Its top-notch purity and integrity instill confidence in obtaining precise and reliable data, thereby enabling significant advancements in my research.

Q&As

What are the potential therapeutic implications of targeting CLDN4 in cancer treatment?

Inhibiting CLDN4 function could enhance the efficacy of existing cancer therapies and potentially lead to the development of new treatment strategies.

How does CLDN4 protein contribute to the pathogenesis of infectious diseases?

CLDN4 is involved in regulating the entry of certain pathogens into host cells, making it a potential target for the development of antiviral and antibacterial therapies.

Can CLDN4 protein be targeted for the treatment of autoimmune diseases?

Research is underway to explore the potential of targeting CLDN4 to modulate tissue barrier function and alleviate the symptoms of autoimmune diseases.

How can CLDN4 protein be utilized in the diagnosis and management of IBD?

Monitoring CLDN4 levels and function may provide valuable insights into the progression of IBD and help in the development of targeted therapies.

In what other clinical settings is CLDN4 protein being investigated?

CLDN4 is also being studied in the context of kidney disease, skin disorders, and neurodegenerative diseases due to its role in maintaining tissue barrier function.