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Recombinant Mouse Cmtm4 Protein, Myc/DDK-tagged

Cat.No. : Cmtm4-2211M
Product Overview : Purified recombinant protein of mouse full-length CKLF-like MARVEL transmembrane domain containing 4 (Cmtm4), with C-terminal MYC/DDK tag, expressed in HEK293T cells.
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Description : Acts as a backup for CMTM6 to regulate plasma membrane expression of PD-L1/CD274, an immune inhibitory ligand critical for immune tolerance to self and antitumor immunity. May protect PD-L1/CD274 from being polyubiquitinated and targeted for degradation.
Source : HEK293T
Species : Mouse
Tag : Myc/DDK
Molecular Mass : 22.9 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Storage : Store at -80 centigrade after receiving vials.
Concentration : >50 μg/mL as determined by microplate BCA method
Storage Buffer : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Gene Name : Cmtm4 CKLF-like MARVEL transmembrane domain containing 4 [ Mus musculus (house mouse) ]
Official Symbol : Cmtm4
Synonyms : CMTM4; CKLF-like MARVEL transmembrane domain containing 4; CKLF-like MARVEL transmembrane domain-containing protein 4; chemokine-like factor super family 4; chemokine-like factor superfamily member 4; D19397; Gm9853; Cklfsf4; MGC30490; MGC32180; ENSMUSG00000051554
Gene ID : 97487
mRNA Refseq : NM_153582
Protein Refseq : NP_705810
UniProt ID : Q8CJ61

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Can changes in CMTM4 protein expression be indicative of disease progression? 04/17/2023

Altered expression of CMTM4 protein has been associated with disease progression in certain cancers, indicating its potential as a prognostic marker for these diseases.

How is CMTM4 protein involved in the regulation of T cell function? 05/29/2022

CMTM4 protein has been shown to enhance T cell activation and effector functions, suggesting its role in modulating immune responses against cancer and infections.

How can CMTM4 protein be targeted for therapeutic purposes? 11/18/2021

Researchers are exploring the possibility of targeting CMTM4 protein to modulate immune responses and potentially develop new therapeutic interventions for cancer and autoimmune diseases.

What are the implications of CMTM4 protein expression in autoimmune diseases? 03/03/2019

Dysregulation of CMTM4 protein expression has been linked to autoimmune diseases, highlighting its potential as a target for developing new treatments for these conditions.

What are the mechanisms by which CMTM4 protein influences immune responses? 08/30/2017

CMTM4 protein interacts with and modulates the activity of immune checkpoint molecules, influencing the function of immune cells and their responses to tumors and pathogens.

Customer Reviews (3)

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Reviews
04/09/2022

    The CMTM4 protein comes highly recommended for a variety of applications, particularly in ELISA and protein electron microscopy structure analysis.

    08/03/2021

      Researchers can rely on the CMTM4 protein's specificity and sensitivity to obtain accurate and reliable results.

      12/19/2016

        researchers highly recommend the CMTM4 protein due to its excellent performance in ELISA and its suitability for protein electron microscopy structure analysis.

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