Recombinant Mouse Csf1 Protein, MYC/DDK-tagged

• Cat.No.: Csf1-043M
• Product Overview: Purified recombinant protein of full-length mouse colony stimulating factor 1 (macrophage) (Csf1), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female fertility. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration. Plays a role in lipoprotein clearance.
• Source: HEK293T
• Species: Mouse
• Tag: MYC/DDK
• Molecular Mass: 61.1 kDa
• Purity: >80%, as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 ug/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Csf1 colony stimulating factor 1 (macrophage) [ Mus musculus (house mouse) ]
• Official Symbol: Csf1
• Synonyms: Csf1; colony stimulating factor 1 (macrophage); op; Csfm; MCSF; C87615; macrophage colony-stimulating factor 1; osteopetrosis; EC 2.7.10.1
• Gene ID: 12977
• mRNA Refseq: NM_007778
• Protein Refseq: NP_031804
• UniProt ID: P07141

Reviews

10/30/2017

The CSF1 protein is renowned for its exceptional quality and reliability, making it an ideal choice to fulfill my experimental requirements.

03/10/2017

With its high purity and stability, this protein ensures dependable and accurate results, which are crucial for the success of my research endeavors.

06/09/2016

Whether it is for investigating cellular pathways, studying protein functions, or exploring signaling cascades, the CSF1 protein offers unparalleled versatility and performance.

Q&As

How does CSF1 affect cancer progression?

CSF1 is implicated in tumor-associated macrophages, influencing tumor growth, invasion, and the tumor microenvironment.

What are the potential side effects of CSF1 therapy?

Side effects may include immune-related adverse events, inflammation, and alterations in white blood cell counts.

Can CSF1 therapy be combined with other treatments?

Yes, there is ongoing research on combining CSF1-targeted therapies with other immunotherapies or conventional treatments to enhance efficacy.

What are the challenges in developing CSF1-based therapies?

Challenges include maintaining the balance of immune responses, potential off-target effects, and variability in patient responses.

In what ways is CSF1 being researched for neurological disorders?

Studies are exploring its role in neuroinflammation, neuroprotection, and potential therapeutic interventions for conditions like Alzheimer's disease.