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Recombinant Mouse CXCL9 Protein, His-tagged

Cat.No. : CXCL9-87M
Product Overview : Recombinant Mouse C-X-C Motif Chemokine 9 is produced by our Mammalian expression system and the target gene encoding Thr22-Thr126 is expressed with a 6His tag at the C-terminus.
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Description : Chemokine (C-X-C motif) ligand 9 (CXCL9, MIG), is a small cytokine belonging to the CXC chemokine family. CXCL9 functions as one of the three ligands of chemokine receptor CXCR3 which is a G protein-coupled receptor found predominantly on T cells. It together with CXCL10 and CXCL11, may activate CXCR3 by binding to it. CXCL9 serves as a cytokine that affects the growth, movement, or activation state of cells that participate in immune and inflammatory response. It has been observed that tumour endothelial cells secrete high levels of CXCL9 in all, and CXCL10 in most melanoma metastases. it plays an important role in CD4+ T lymphocyte recruitment and development of CAV, MOMA-2+ macrophages are the predominant recipient-derived source of CXCL9, and recipient CD4 lymphocytes are necessary for sustained CXCL9 production and CAV development in this model.
Source : Human Cells
Species : Mouse
Tag : His
Form : Lyophilized from a 0.2 um filtered solution of PBS, pH7.4.
AA Sequence : Thr22-Thr126
Endotoxin : Less than 0.1 ng/ug (1 EU/ug).
Shipping : Ambient
Gene Name : Cxcl9 chemokine (C-X-C motif) ligand 9 [ Mus musculus (house mouse) ]
Official Symbol : CXCL9
Synonyms : C-X-C motif chemokine 9; Gamma-interferon-induced monokine; Monokine induced by interferon-gamma; MIG; MuMIG; Protein m119; Small-inducible cytokine B9; Cxcl9; Mig; Scyb9; CMK; MuMIG; crg-10
Gene ID : 17329
mRNA Refseq : NM_008599.4
Protein Refseq : NP_032625.2
UniProt ID : P18340

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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What is the relationship between CXCL9 and the chemokine receptor CXCR3? 08/16/2022

CXCL9 can bind specifically to CXCR3 and accumulate at sites of inflammation, thereby inducing and exacerbating the inflammatory response.

Do you offer CXCL9 fused with other tags? 01/25/2022

Yes, we will provide you with the most suitable labels according to your experimental needs.

Can CXCL9 be detected in lymphoid tissue under normal physiological conditions? 11/23/2020

No, CXCL9 can only be detected when the organism is inflamed or infected.

CXCL9 is secreted by which cells? 11/21/2020

CXCL9 is mainly secreted by endothelial cells and monocytes.

What diseases has CXCL9 been closely associated with the study of? 10/19/2020

CXCL9 has been linked to pulmonary embolism, asthma and breast cancer research.

Customer Reviews (2)

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Reviews
02/21/2023

    Customer service promptly feedback my requests, technical staff timely solve the problems that arise.

    04/01/2022

      The protein composition was stable and the concentration was high, which allowed me to obtain satisfactory experimental results.

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