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Recombinant Mouse Cyp2e1 Protein, Myc/DDK-tagged

Cat.No. : Cyp2e1-2417M
Product Overview : Purified recombinant protein of mouse full-length cytochrome P450, family 2, subfamily e, polypeptide 1 (Cyp2e1), with C-terminal MYC/DDK tag, expressed in HEK293T cells.
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Description : A cytochrome P450 monooxygenase involved in the metabolism of fatty acids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Hydroxylates fatty acids specifically at the omega-1 position displaying the highest catalytic activity for saturated fatty acids. May be involved in the oxidative metabolism of xenobiotics.
Source : HEK293T
Species : Mouse
Tag : Myc/DDK
Molecular Mass : 57.3 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Storage : Store at -80 centigrade after receiving vials.
Concentration : >50 μg/mL as determined by microplate BCA method
Storage Buffer : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Gene Name : Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 [ Mus musculus (house mouse) ]
Official Symbol : Cyp2e1
Synonyms : CYP2E1; cytochrome P450, family 2, subfamily e, polypeptide 1; cytochrome P450 2E1; CYPIIE1; cytochrome P450-J; cytochrome P450-ALC; 4-nitrophenol 2-hydroxylase; cytochrome P450, 2e1, ethanol inducible; Cyp2e
Gene ID : 13106
mRNA Refseq : NM_021282
Protein Refseq : NP_067257
UniProt ID : Q05421

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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Are there known genetic polymorphisms in CYP2E1 associated with altered drug metabolism or disease risk? 05/03/2022

Genetic polymorphisms in CYP2E1 can result in altered enzyme activity, influencing an individual's response to drugs and susceptibility to liver damage.

What is the main function of CYP2E1 in drug metabolism? 10/19/2021

CYP2E1 oxidizes and metabolizes various small molecules, including drugs and toxins.

How does CYP2E1 contribute to the metabolism of ethanol and other toxins? 02/27/2021

It plays a significant role in ethanol metabolism and helps detoxify industrial solvents and other xenobiotics.

What factors can induce the expression of CYP2E1? 08/08/2020

Ethanol, fasting, and certain drugs can induce the expression of CYP2E1.

How is CYP2E1 linked to the generation of reactive oxygen species (ROS)? 11/15/2019

CYP2E1 activity generates ROS, contributing to oxidative stress and potential cellular damage.

In which tissues is CYP2E1 predominantly expressed? 01/24/2019

CYP2E1 is highly expressed in the liver, which is the main site for drug metabolism.

What role does CYP2E1 play in drug-drug interactions? 08/05/2018

CYP2E1 can contribute to drug-drug interactions, affecting the efficacy and toxicity of co-administered drugs.

Customer Reviews (3)

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Reviews
07/04/2022

    Product is as described.

    04/12/2022

      Fast and efficient service.

      12/19/2020

        Great for biological experiments.

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