Recombinant Mouse Dnaja3 Protein, Myc/DDK-tagged

• Cat.No.: Dnaja3-2593M
• Product Overview: Purified recombinant protein of mouse full-length DnaJ heat shock protein family (Hsp40) member A3 (Dnaja3), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: Modulates apoptotic signal transduction or effector structures within the mitochondrial matrix. Affect cytochrome C release from the mitochondria and caspase 3 activation, but not caspase 8 activation. Isoform 1 increases apoptosis triggered by both TNF and the DNA-damaging agent mytomycin C; in sharp contrast, isoform 2 suppresses apoptosis. Can modulate IFN-gamma-mediated transcriptional activity. Isoform 2 may play a role in neuromuscular junction development as an effector of the MUSK signaling pathway.
• Source: HEK293T
• Species: Mouse
• Tag: Myc/DDK
• Molecular Mass: 52.9 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Dnaja3 DnaJ heat shock protein family (Hsp40) member A3 [ Mus musculus (house mouse) ]
• Official Symbol: Dnaja3
• Synonyms: DNAJA3; DnaJ (Hsp40) homolog, subfamily A, member 3; dnaJ homolog subfamily A member 3, mitochondrial; mTid-1; dnaJ protein Tid-1; tumorous imaginal discs protein Tid56 homolog; Tid-1; Tid1l; C81173; 1200003J13Rik; 1810053A11Rik
• Gene ID: 83945
• mRNA Refseq: NM_023646
• Protein Refseq: NP_076135
• UniProt ID: Q99M87