Recombinant Mouse Fibroblast Growth Factor 23, Fc Chimera

• Cat.No.: Fgf23-417M
• Product Overview: Recombinant mouse FGF-23 (aa 1-251) produced inHEK 293 cellsare fused at the C-terminus to the Fc portion of human IgG.

Specification

• Cat. No.: Fgf23-417M
• Description: FGF-23 is a member of the fibroblast growth factor (FGF) family. FGF-23 inhibits renal tubular phosphate transport. This gene was identified by its mutations associated with autosomal dominant hypophosphatemic rickets (ADHR), an inherited phosphate wasting disorder. Abnormally high level expression of FGF23 was found in oncogenic hypophosphatemic osteomalacia (OHO), a phenotypically similar disease caused by abnormal phosphate metabolism. Mutations FGF23 have also been shown to cause familial tumoral calcinosis with hyperphosphatemia.
• Source/Host: HEK 293 cells.
• Purity: ≥90% (SDS-PAGE).
• Formulation: Liquid. 0.2μm-filtered solution in PBS.
• Endotoxin Content: <1EU/µg protein (LAL-test).
• Long Term Storage: -20°C.
• Use/Stability: Working aliquots are stable for up to 3 months when stored at -20°C.
• Handling: Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.

Gene Information

• Gene Name: Fgf23 fibroblast growth factor 23 [ Mus musculus ]
• Synonyms: fibroblast growth factor 23; Fgf23; FGF-23
• Gene ID: 64654
• mRNA Refseq: NM_022657
• Protein Refseq: NP_073148
• UniProt ID: Q9EPC2
• Chromosome Location: 6 F3
• Pathway: MAPK signaling pathway; Melanoma; Pathways in cancer; Regulation of actin cytoskeleton
• Function: type 1 fibroblast growth factor receptor binding; fibroblast growth factor receptor binding; growth factor activity; protein binding