Recombinant Active Human FGF23 Protein, His-tagged(C-ter)

Cat.No. : FGF23-83H
Product Overview : Recombinant Active Human FGF23 Protein with His tag (C-ter) was expressed in E. coli.
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Description : This gene encodes a member of the fibroblast growth factor family of proteins, which possess broad mitogenic and cell survival activities and are involved in a variety of biological processes. The product of this gene regulates phosphate homeostasis and transport in the kidney. The full-length, functional protein may be deactivated via cleavage into N-terminal and C-terminal chains. Mutation of this cleavage site causes autosomal dominant hypophosphatemic rickets (ADHR). Mutations in this gene are also associated with hyperphosphatemic familial tumoral calcinosis (HFTC). [provided by RefSeq, Feb 2013]
Source : E. coli
Species : Human
Tag : His(C-ter)
Form : Powder
Bio-activity : Determined by its ability to induce proliferation in BaF3 mouse pro-B cells transfected with human FGFRIIIc. The ED50 for this effect is < 0.3 μg/mL.
AA Sequence : MYPNASPLLGSSWGGLIHLYTATAR NSYHLQIHKNGHVDGAPHQTIYSAL MIRSEDAGFVVITGVMSRRYLCMDF RGNIFGSHYFDPENCRFQHQTLENG YDVYHSPQYHFLVSLGRAKRAFLPG MNPPPYSQFLSRRNEIPLIHFNTPI PRRHTRSAEDDSERDPLNVLKPRAR MTPAPASCSQELPSAEDNSPMASDP LGVVRGGRVNTHAGGTGPEGCRPFA KFI
Endotoxin : Endotoxin level is less than 0.1 EU/μg of the protein, as determined by the LAL test.
Purity : > 98% (by SDS-PAGE)
Applications : SDS-PAGE
Notes : For laboratory research only, not for drug, diagnostic or other use.
Storage : Lyophilized protein should be stored at -20°C. After reconstitution, aliquot and store at -20°C or -80°C for up to one month. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening.
Storage Buffer : PBS (pH 8.0)
Reconstitution : It is recommended to reconstitute the lyophilized protein in sterile water to a concentration not less than 100 μg/mL and incubate the stock solution for at least 20 min at room temperature to make sure the protein is dissolved completely.
Gene Name : FGF23 fibroblast growth factor 23 [ Homo sapiens ]
Official Symbol : FGF23
Synonyms : FGF23; fibroblast growth factor 23;
Gene ID : 53406

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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What role does FGF23 play in chronic kidney disease? 06/12/2022

FGF23 levels are elevated in chronic kidney disease, contributing to mineral imbalance.

How is FGF23 implicated in cardiovascular health? 04/04/2022

High FGF23 levels are associated with increased cardiovascular risk.

How does FGF23 regulate phosphate and calcium homeostasis? 03/24/2022

It decreases renal phosphate reabsorption and 1,25-dihydroxyvitamin D production.

Are there known genetic mutations that affect FGF23 production or activity? 01/27/2022

Mutations in FGF23 or related proteins can lead to dysregulated phosphate metabolism.

What therapeutic strategies are being explored to modulate FGF23 levels? 05/16/2020

Strategies include phosphate binders and FGF23 antibodies to manage elevated FGF23 levels.

In which tissues is FGF23 predominantly produced and secreted? 04/28/2020

FGF23 is primarily produced in bone.

What is the primary function of FGF23 in the body? 10/29/2019

FGF23 regulates phosphate and vitamin D metabolism.

Customer Reviews (3)

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Reviews
07/23/2022

    Excellent results, high purity.

    07/17/2021

      Reliable and effective product.

      11/26/2020

        Quick delivery, product works.

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