Recombinant Active Human FGF23 Protein, His-tagged(C-ter)
|Product Overview :
|Recombinant Active Human FGF23 Protein with His tag (C-ter) was expressed in E. coli.
- Gene Information
- Related Products
|This gene encodes a member of the fibroblast growth factor family of proteins, which possess broad mitogenic and cell survival activities and are involved in a variety of biological processes. The product of this gene regulates phosphate homeostasis and transport in the kidney. The full-length, functional protein may be deactivated via cleavage into N-terminal and C-terminal chains. Mutation of this cleavage site causes autosomal dominant hypophosphatemic rickets (ADHR). Mutations in this gene are also associated with hyperphosphatemic familial tumoral calcinosis (HFTC). [provided by RefSeq, Feb 2013]
|Determined by its ability to induce proliferation in BaF3 mouse pro-B cells transfected with human FGFRIIIc. The ED50 for this effect is < 0.3 μg/mL.
|AA Sequence :
|MYPNASPLLGSSWGGLIHLYTATAR NSYHLQIHKNGHVDGAPHQTIYSAL MIRSEDAGFVVITGVMSRRYLCMDF RGNIFGSHYFDPENCRFQHQTLENG YDVYHSPQYHFLVSLGRAKRAFLPG MNPPPYSQFLSRRNEIPLIHFNTPI PRRHTRSAEDDSERDPLNVLKPRAR MTPAPASCSQELPSAEDNSPMASDP LGVVRGGRVNTHAGGTGPEGCRPFA KFI
|Endotoxin level is less than 0.1 EU/μg of the protein, as determined by the LAL test.
|> 98% (by SDS-PAGE)
|For laboratory research only, not for drug, diagnostic or other use.
|Lyophilized protein should be stored at -20°C. After reconstitution, aliquot and store at -20°C or -80°C for up to one month. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening.
|Storage Buffer :
|PBS (pH 8.0)
|It is recommended to reconstitute the lyophilized protein in sterile water to a concentration not less than 100 μg/mL and incubate the stock solution for at least 20 min at room temperature to make sure the protein is dissolved completely.
|Gene Name :
|FGF23 fibroblast growth factor 23 [ Homo sapiens ]
|Official Symbol :
|FGF23; fibroblast growth factor 23;
|Gene ID :
|◆ Recombinant Protein
|Recombinant Human FGF23 Protein, His-tagged
|Recombinant Human FGF23 Protein, His (Fc)-Avi-tagged
|Recombinant Human FGF23 Protein, GST-tagged
|Recombinant Rat FGF23 Protein, His (Fc)-Avi-tagged
|Recombinant Human FGF23 Protein (Y25-R179), Tag Free
|Recombinant Human FGF23 293 Cell Lysate
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Q&As (7)Ask a question
FGF23 levels are elevated in chronic kidney disease, contributing to mineral imbalance.
High FGF23 levels are associated with increased cardiovascular risk.
It decreases renal phosphate reabsorption and 1,25-dihydroxyvitamin D production.
Mutations in FGF23 or related proteins can lead to dysregulated phosphate metabolism.
Strategies include phosphate binders and FGF23 antibodies to manage elevated FGF23 levels.
FGF23 is primarily produced in bone.
FGF23 regulates phosphate and vitamin D metabolism.
Customer Reviews (3)Write a review
Excellent results, high purity.
Reliable and effective product.
Quick delivery, product works.
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