Recombinant Mouse Gfral Protein, Fc-tagged
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| Cat.No. : | Gfral-6321M |
| Product Overview : | The extracellular domain of mouse GFRAL (aa 20-349) fused to the N-terminus of the Fc region of mouse IgG2a was expressed in HEK 293 cells. |
| Description : | GFRAL (GDNF receptor α-like) is a distant member of the GDNFR family of proteins. Mouse GFR α-like contains a 330aa extracellular domain. It is expressed on hindbrain neurons of the CNS and functions as an anti-apoptotic molecule during neuronal stress. GFRAL is a functional receptor for GDF15, facilitating weight-loss functions of the protein through c-Ret downstream signaling. GFRAL and GDF15 signaling is implicated in diet-based obesity and insulin resistance. |
| Source : | HEK 293 Cells |
| Species : | Mouse |
| Tag : | Fc |
| Bio-activity : | Measured by its binding ability in a functional ELISA. |
| Endotoxin : | <0.06 EU/μg purified protein. |
| Purity : | ≥98% (SDS-PAGE) |
| Stability : | Stable for at least 1 year after receipt when stored at -20 centigrade. Working aliquots are stable for up to 3 months when stored at -20 centigrade. Avoid freeze/thaw cycles. |
| Storage : | Short term storage at +4 centigrade, long term storage at -20 centigrade. |
| Storage Buffer : | Lyophilized from 0.2 μm-filtered solution in PBS. |
| Reconstitution : | Reconstitute at 100 μg/mL in sterile PBS. |
| Shipping : | BLUE ICE |
| Gene Name : | Gfral GDNF family receptor alpha like [ Mus musculus (house mouse) ] |
| Official Symbol : | Gfral |
| Synonyms : | Gfral; GDNF family receptor alpha like; Gral; AY457637; GDNF family receptor alpha-like; GDNF receptor alpha-like |
| Gene ID : | 404194 |
| mRNA Refseq : | NM_205844 |
| Protein Refseq : | NP_995316 |
| UniProt ID : | Q6SJE0 |
◆ Recombinant Protein
| GFRAL-1929H | Recombinant Human GFRAL Protein (19-351 aa), His-SUMO-tagged | +Inquiry |
| GFRAL-22H | Recombinant Human GFRAL Protein, His-tagged | +Inquiry |
| GFRAL-001H | Recombinant Human GFRAL Protein, Fc-tagged | +Inquiry |
| GFRAL-1493H | Recombinant Human GFRAL protein, His-tagged | +Inquiry |
| GFRAL-60H | Recombinant Human GFRAL protein, His-Avi-tagged | +Inquiry |
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