Recombinant Mouse Grb10 Protein, MYC/DDK-tagged Grb10-1053M

Recombinant Mouse Grb10 Protein, MYC/DDK-tagged

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Recombinant Mouse Grb10 Protein, MYC/DDK-tagged

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Cat.No. : Grb10-1053M
Product Overview : Purified recombinant protein of full-length mouse growth factor receptor bound protein 10 (Grb10), with C-terminal MYC/DDK tag, was expressed in HEK293T cells.
Description : Adapter protein which modulates coupling of a number of cell surface receptor kinases with specific signaling pathways. Binds to, and suppress signals from, activated receptors tyrosine kinases, including the insulin (INSR) and insulin-like growth factor (IGF1R) receptors. The inhibitory effect can be achieved by 2 mechanisms: interference with the signaling pathway and increased receptor degradation. Delays and reduces AKT1 phosphorylation in response to insulin stimulation. Blocks association between INSR and IRS1 and IRS2 and prevents insulin-stimulated IRS1 and IRS2 tyrosine phosphorylation. Recruits NEDD4 to IGF1R, leading to IGF1R ubiquitination, increased internalization and degradation by both the proteasomal and lysosomal pathways. A similar role in the mediation of ubiquitination has also been suggested with INSR. Negatively regulates Wnt signaling by interacting with LRP6 intracellular portion and interfering with the binding of AXIN1 to LRP6. Positive regulator of the KDR/VEGFR-2 signaling pathway. May inhibit NEDD4-mediated degradation of KDR/VEGFR-2.
Source : HEK293T
Species : Mouse
Tag : MYC/DDK
Molecular Mass : 61.2 kDa
Purity : >80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Storage : Store at -80 centigrade after receiving vials.
Concentration : >50 µg/mL as determined by microplate BCA method
Storage Buffer : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Gene Name : Grb10 growth factor receptor bound protein 10 [ Mus musculus (house mouse) ]
Official Symbol : Grb10
Synonyms : Grb10; growth factor receptor bound protein 10; Meg1; AI325020; mKIAA0207; 5730571D09Rik; growth factor receptor-bound protein 10; GRB10 adapter protein; maternally expressed gene 1 protein
Gene ID : 14783
mRNA Refseq : NM_001177629
Protein Refseq : NP_001171100
UniProt ID : Q60760

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