Grb14-3303M
Optional Service: Optional requirements on this protein
Product Overview :
Purified recombinant protein of mouse full-length growth factor receptor bound protein 14 (Grb14), with C-terminal MYC/DDK tag, expressed in HEK293T cells.
Description :
Adapter protein which modulates coupling of cell surface receptor kinases with specific signaling pathways. Binds to, and suppresses signals from, the activated insulin receptor (INSR). Potent inhibitor of insulin-stimulated MAPK3 phosphorylation. Plays a critical role regulating PDPK1 membrane translocation in response to insulin stimulation and serves as an adapter protein to recruit PDPK1 to activated insulin receptor, thus promoting PKB/AKT1 phosphorylation and transduction of the insulin signal.
Source :
HEK293T
Species :
Mouse
Tag :
Myc/DDK
Molecular Mass :
60.6 kDa
Purity :
> 80% as determined by SDS-PAGE and Coomassie blue staining
Stability :
Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Storage :
Store at -80 centigrade after receiving vials.
Concentration :
>50 μg/mL as determined by microplate BCA method
Storage Buffer :
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.