| Species : |
Mouse |
| Source : |
E.coli |
| Protein Length : |
29-161 a.a. |
| Description : |
Ligand for IL17RA and IL17RC. The heterodimer formed by IL17A and IL17F is a ligand for the heterodimeric complex formed by IL17RA and IL17RC. Involved in stimulating the production of other cytokines such as IL6, IL8 and CSF2, and in regulation of cartilage matrix turnover. Also involved in stimulating the proliferation of peripheral blood mononuclear cells and T-cells and in inhibition of angiogenesis. Plays a role in the induction of neutrophilia in the lungs and in the exacerbation of antigen-induced pulmonary allergic inflammation. |
| Bio-activity : |
The ED50 is 300 to 600 ng/ml, corresponding to a specific activity of 0.16 - 0.33 x 10^4 units/mg, determined by a dose dependent stimulation of fetal mouse skin fibroblasts production of CXCL1. |
| Molecular Mass : |
15 kDa |
| Endotoxin : |
Less than 0.01 ng per µg protein as determined by the LAL method |
| Purity : |
>98%, as determined by Coomassie stained SDS-PAGE. |
| Stability : |
Unopened vial can be stored between 2 centigrade and 8 centigrade for up to 2 weeks, at -20 centigrade for up to 6 months, or at -70 centigrade or below until the expiration date. Aliquots can be stored between 2 centigrade and 8 centigrade for up to one week and stored at -20 centigrade or colder for up to 3 months. Avoid repeated freeze/thaw cycles. |
| Storage : |
Store at -80 centigrade. |
| Concentration : |
Protein formulated and vialed at >50 ug/mL in specified buffer |
| Storage Buffer : |
10 mM NaH2PO4, 0.15 M NaCl, pH7.2 |
