Recombinant Mouse Il2ra protein, His-tagged
|Product Overview :||Recombinant Mouse Il2ra (Glu22-Lys236) protein was fused to His-tag at C-terminus and expressed in human 293 cells (HEK293).|
- Gene Information
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|Description :||Interleukin-2 receptor subunit alpha (IL2RA) is also known as IL-2R subunit alpha, IL-2-RA, IL2-RA, TAC antigen, p55, CD antigen CD25, is a type I transmembrane glycoprotein. IL2RA is expressed on activated T cells and regulatory T cells, and is capable of binding IL2 with low affinity by itself. However, a ligand-induced high affinity heterotrimeric receptor complex is produced when IL2RA is associated non-covelently with the IL2 receptor beta and gamma chain, and subsequently initiates the intacellular signal pathways such as MAPK or JAK/STAT. On dendritic cells (DC), CD25 has been previously regarded as an activation marker, while both murine and human DC can express CD25, they do not express the beta-chain of the IL-2 receptor, which is indispensable for the execution of IL-2 signaling.|
|Predicted N Terminal :||Glu22|
|Form :||Lyophilized from 0.22 μm filtered solution in PBS, pH7.4, 10% trehalose.|
|Molecular Mass :||The protein has a calculated MW of 26.6 kDa. The protein migrates as 40-60 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.|
|Protein length :||Glu22-Lys236|
|Endotoxin :||Less than 1.0 EU per μg by the LAL method.|
|Purity :||>90% as determined by SDS-PAGE.|
|Storage :||For long term storage, the product should be stored at lyophilized state at -20 centigrade or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20 to -70 centigrade for 12 months in lyophilized state;
-70 centigrade for 3 months under sterile conditions after reconstitution.
|Reconstitution :||It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4ºC before opening to recover the entire contents.|
|Gene Name :||Il2ra|
|Official Symbol :||Il2ra|
|Synonyms :||IL2RA; interleukin 2 receptor, alpha chain; interleukin-2 receptor subunit alpha; IL2-RA; IL-2-RA; p55 chain; IL-2R alpha chain; IL-2R subunit alpha; IL-2 receptor subunit alpha; CD25; Il2r; Ly-43; MGC130561|
|Gene ID :||16184|
|mRNA Refseq :||NM_008367|
|Protein Refseq :||NP_032393|
|UniProt ID :||P01590|
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Q&As (6)Ask a question
The combination of IL2RA and other drugs may produce nausea, vomiting, rash and other adverse reactions, should be monitored.
The frequency of use of IL2RA depends on the specific situation of the patient, and is generally used 1-3 times per week.
IL2RA, in the right dosage and frequency of use, can significantly relieve symptoms of diseases such as autoimmune diseases and organ transplant rejection.
Can assist in the treatment of some types of malignant tumors, but it is not a complete cure for cancer.
The effective rate of IL2RA therapy depends on many factors such as the type of disease, the patient's condition and the treatment regimen, and the effective rate is generally between 50% and 90%.
Indications of IL2RA include a variety of autoimmune diseases, organ transplant rejection and malignant tumors.
Customer Reviews (3)Write a review
Structural stability of IL2RA, that is, whether it can maintain its structural integrity and functional activity under different conditions such as temperature, pH value and storage time, HPLC, CD spectroscopy and other techniques can be used to evaluate the stability. -
Solubility and stability of IL2RA in physiological buffers to ensure its reliability in practical applications. -
To evaluate whether IL2RA has biological activity, we can verify its IL-2 binding ability and signal transduction ability through cell experiments, which are the key functions of IL2RA. -
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