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Recombinant Mouse Inip Protein, Myc/DDK-tagged

Cat.No. : Inip-3540M
Product Overview : Purified recombinant protein of mouse full-length INTS3 and NABP interacting protein (Inip), with C-terminal MYC/DDK tag, expressed in HEK293T cells.
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Description : Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. The SOSS complex associates with single-stranded DNA at DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways.
Source : HEK293T
Species : Mouse
Tag : Myc/DDK
Molecular Mass : 11.4 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Storage : Store at -80 centigrade after receiving vials.
Concentration : >50 μg/mL as determined by microplate BCA method
Storage Buffer : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Gene Name : Inip INTS3 and NABP interacting protein [ Mus musculus (house mouse) ]
Official Symbol : Inip
Synonyms : Inip; INTS3 and NABP interacting protein; Ssbip1; AA399876; 1110054O05Rik; 2610312O17Rik; SOSS complex subunit C; SOSS-C; SSB-interacting protein 1; sensor of single-strand DNA complex subunit C; sensor of ssDNA subunit C; single-stranded DNA-binding protein-interacting protein 1
Gene ID : 66209
mRNA Refseq : NM_001013577
Protein Refseq : NP_001013595
UniProt ID : Q3TXT3

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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What is the SOSS complex, and what does it do? 12/21/2022

The SOSS complex operates downstream of the MRN complex, promoting DNA repair and the G2/M checkpoint.

How does the SOSS complex interact with DNA lesions? 06/18/2022

It associates with single-stranded DNA at sites of DNA damage.

Why is the G2/M checkpoint important in cell division? 02/15/2019

It ensures that DNA is intact before cells progress to the mitotic phase.

What is the role of the INIP protein in the cell? 10/30/2017

It is a component of the SOSS complex, involved in DNA repair and the G2/M checkpoint.

What specific DNA repair process relies on INIP? 08/26/2017

It is required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs).

Which signaling pathway is influenced by INIP? 03/25/2017

INIP impacts ATM-dependent signaling pathways.

What is the impact of the SOSS complex on the cellular DNA damage response? 01/06/2017

It influences cell-cycle checkpoint activation, recombinational repair, and the maintenance of genomic stability.

Customer Reviews (3)

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Reviews
10/06/2021

    We appreciated the option to request modifications or custom formulations to meet our project's requirements.

    05/03/2021

      Its versatility in integrating with other laboratory reagents streamlined our workflow and improved efficiency.

      07/16/2019

        We found the product to be a flexible tool that could be tailored to meet the specific demands of our research.

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