Recombinant Mouse Itga6 Protein, Myc/DDK-tagged

• Cat.No.: Itga6-3597M
• Product Overview: Purified recombinant protein of mouse full-length integrin alpha 6 (Itga6), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: This gene encodes a protein that is a member of the integrin superfamily. Integrins are transmembrane receptors involved cell adhesion and signaling, and they are subdivided based on the heterodimer formation of alpha and beta chains. This protein has been shown to heterodimerize with beta 4 to bind laminin and to form the main component of hemidesmosomes, which mediate attachment of epithelia to basement membranes. In mouse, deficiency of this gene is associated with absence of hemidesmosomes, severe skin blistering, and early post-natal death. In humans mutations of this gene are associated with epidermolysis bullosa. Alternative splicing results in multiple transcript variants that encode different protein isoforms.
• Source: HEK293T
• Species: Mouse
• Tag: Myc/DDK
• Molecular Mass: 120.1 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Itga6 integrin alpha 6 [ Mus musculus (house mouse) ]
• Official Symbol: Itga6
• Synonyms: ITGA6; integrin alpha 6; integrin alpha-6; VLA-6; CD49 antigen-like family member F; Cd49f; AI115430; 5033401O05Rik
• Gene ID: 16403
• mRNA Refseq: NM_008397
• Protein Refseq: NP_032423
• UniProt ID: Q8CC06