Recombinant Mouse Kdm6a Protein, Myc/DDK-tagged

• Cat.No.: Kdm6a-3683M
• Product Overview: Purified recombinant protein of mouse full-length lysine (K)-specific demethylase 6A (Kdm6a), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: Histone demethylase that specifically demethylates 'Lys-27' of histone H3, thereby playing a central role in histone code. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-27'. Plays a central role in regulation of posterior development, by regulating HOX gene expression. Demethylation of 'Lys-27' of histone H3 is concomitant with methylation of 'Lys-4' of histone H3, and regulates the recruitment of the PRC1 complex and monoubiquitination of histone H2A. Plays a demethylase-independent role in chromatin remodeling to regulate T-box family member-dependent gene expression.
• Source: HEK293T
• Species: Mouse
• Tag: Myc/DDK
• Molecular Mass: 157.9 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Kdm6a lysine (K)-specific demethylase 6A [ Mus musculus (house mouse) ]
• Official Symbol: Kdm6a
• Synonyms: KDM6A; lysine (K)-specific demethylase 6A; lysine-specific demethylase 6A; histone demethylase UTX; 4lysine (K)-specific demethylase 6A; ubiquitously transcribed TPR protein on the X chromosome; ubiquitously transcribed tetratricopeptide repeat gene, X chromosome; ubiquitously transcribed X chromosome tetratricopeptide repeat protein; Utx
• Gene ID: 22289
• mRNA Refseq: NM_009483
• Protein Refseq: NP_033509
• UniProt ID: O70546