Recombinant Mouse Mapk7 Protein, Myc/DDK-tagged

• Cat.No.: Mapk7-3944M
• Product Overview: Purified recombinant protein of mouse full-length mitogen-activated protein kinase 7 (Mapk7), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: Plays a role in various cellular processes such as proliferation, differentiation and cell survival. The upstream activator of MAPK7 is the MAPK kinase MAP2K5. Upon activation, it translocates to the nucleus and phosphorylates various downstream targets including MEF2C. EGF activates MAPK7 through a Ras-independent and MAP2K5-dependent pathway. May have a role in muscle cell differentiation. May be important for endothelial function and maintenance of blood vessel integrity. MAP2K5 and MAPK7 interact specifically with one another and not with MEK1/ERK1 or MEK2/ERK2 pathways. Phosphorylates SGK1 at Ser-78 and this is required for growth factor-induced cell cycle progression. Involved in the regulation of p53/TP53 by disrupting the PML-MDM2 interaction.
• Source: HEK293T
• Species: Mouse
• Tag: Myc/DDK
• Molecular Mass: 88.2 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Mapk7 mitogen-activated protein kinase 7 [ Mus musculus (house mouse) ]
• Official Symbol: Mapk7
• Synonyms: MAPK7; mitogen-activated protein kinase 7; BMK-1; ERK-5; MAPK 7; MAP kinase 7; big MAP kinase 1; mitogen-activated kinase 7; mitogen activated protein kinase 7; extracellular signal regulated kinase 5; extracellular signal-regulated kinase 5; BMK1; ERK5; PRKM7; Erk5-T
• Gene ID: 23939
• mRNA Refseq: NM_011841
• Protein Refseq: NP_035971
• UniProt ID: Q9WVS8