Recombinant Mouse Meox1 Protein, Myc/DDK-tagged

• Cat.No.: Meox1-4033M
• Product Overview: Purified recombinant protein of mouse full-length mesenchyme homeobox 1 (Meox1), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: Mesodermal transcription factor that plays a key role in somitogenesis and is specifically required for sclerotome development. Required for maintenance of the sclerotome polarity and formation of the cranio-cervical joints. Binds specifically to the promoter of target genes and regulates their expression. Activates expression of NKX3-2 in the sclerotome. Activates expression of CDKN1A and CDKN2A in endothelial cells, acting as a regulator of vascular cell proliferation. While it activates CDKN1A in a DNA-dependent manner, it activates CDKN2A in a DNA-independent manner. Required for hematopoietic stem cell (HSCs) induction via its role in somitogenesis: specification of HSCs occurs via the deployment of a specific endothelial precursor population, which arises within a sub-compartment of the somite named endotome.
• Source: HEK293T
• Species: Mouse
• Tag: Myc/DDK
• Molecular Mass: 28 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Meox1 mesenchyme homeobox 1 [ Mus musculus (house mouse) ]
• Official Symbol: Meox1
• Synonyms: MEOX1; mesenchyme homeobox 1; homeobox protein MOX-1; Mox1; Mox-1; AI385561; D330041M02Rik
• Gene ID: 17285
• mRNA Refseq: NM_010791
• Protein Refseq: NP_034921
• UniProt ID: P32442