Recombinant Mouse Myl2 Protein, Myc/DDK-tagged

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Recombinant Mouse Myl2 Protein, Myc/DDK-tagged

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Cat.No. : MYL2-10314M
Product Overview : Purified recombinant protein of Mouse myosin, light polypeptide 2, regulatory, cardiac, slow (Myl2), with C-terminal MYC/DDK tag, expressed in HEK293T cells.
Description : Contractile protein that plays a role in heart development and function (PubMed:10409661). Following phosphorylation, plays a role in cross-bridge cycling kinetics and cardiac muscle contraction by increasing myosin lever arm stiffness and promoting myosin head diffusion; as a consequence of the increase in maximum contraction force and calcium sensitivity of contraction force. These events altogether slow down myosin kinetics and prolong duty cycle resulting in accumulated myosins being cooperatively recruited to actin binding sites to sustain thin filament activation as a means to fine-tune myofilament calcium sensitivity to force (By similarity) (PubMed:22426213, PubMed:16908724, PubMed:10409661). During cardiogenesis plays an early role in cardiac contractility by promoting cardiac myofibril assembly (PubMed:9422794).
Source : HEK293T
Species : Mouse
Tag : Myc/DDK
Molecular Mass : 18.8 kDa
Purity : >80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Storage : Store at -80 centigrade after receiving vials.
Concentration : >50 μg/mL as determined by microplate BCA method
Storage Buffer : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Gene Name : Myl2 myosin, light polypeptide 2, regulatory, cardiac, slow [ Mus musculus (house mouse) ]
Official Symbol : Myl2
Synonyms : Myl2; myosin, light polypeptide 2, regulatory, cardiac, slow; Mlc; Myl; MLC-; MLC-2; Mlc2v; Mylpc; MLC-2v; Gm32672; MLC-2s/v; myosin regulatory light chain 2, ventricular/cardiac muscle isoform; myosin light chain 2v; myosin light chain, phosphorylatable, cardiac ventricles
Gene ID : 17906
mRNA Refseq : NM_010861
Protein Refseq : NP_034991
UniProt ID : P51667
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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