Recombinant Mouse Pde12 Protein, Myc/DDK-tagged

• Cat.No.: Pde12-4741M
• Product Overview: Purified recombinant protein of mouse full-length phosphodiesterase 12 (Pde12), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: Enzyme that cleaves 2',5'-phosphodiester bond linking adenosines of the 5'-triphosphorylated oligoadenylates, triphosphorylated oligoadenylates referred as 2-5A modulates the 2-5A system. Degrades triphosphorylated 2-5A to produce AMP and ATP. Also cleaves 3',5'-phosphodiester bond of oligoadenylates. Plays a role as a negative regulator of the 2-5A system that is one of the major pathways for antiviral and antitumor functions induced by interferons (IFNs). Suppression of this enzyme increases cellular 2-5A levels and decreases viral replication in cultured small-airway epithelial cells.
• Source: HEK293T
• Species: Mouse
• Tag: Myc/DDK
• Molecular Mass: 67.5 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Pde12 phosphodiesterase 12 [ Mus musculus (house mouse) ]
• Official Symbol: Pde12
• Synonyms: PDE12; phosphodiesterase 12; 2,5-phosphodiesterase 12; 2-PDE; 2-phosphodiesterase; E430028B21Rik
• Gene ID: 211948
• mRNA Refseq: NM_178668
• Protein Refseq: NP_848783
• UniProt ID: Q3TIU4