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Active Recombinant Mouse Pf4 Protein

Cat.No. : Pf4-4803M
Product Overview : Purified recombinant protein of Mouse platelet factor 4 (Pf4 / PF-4) without tag was expressed in E. coli.
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  • Gene Information
  • Related Products
Description : Released during platelet aggregation. Neutralizes the anticoagulant effect of heparin because it binds more strongly to heparin than to the chondroitin-4-sulfate chains of the carrier molecule. Chemotactic for neutrophils and monocytes. Inhibits endothelial cell proliferation.
Source : E. coli
Species : Mouse
Bio-activity : The ED50 is 3-5 μg/ml, corresponding to a specific activity 2.0-3.3 × 10^2 units/mg, determined by a dose-dependent inhibition of human FGF-basic-dependent proliferation of human umbilical vein endothelial cells (HUVEC).
Molecular Mass : 8.2 kDa
Protein length : Val30-Ser105
Endotoxin : Less than 0.01 ng/μg protein as determined by the LAL method
Purity : > 98%, as determined by Coomassie stained SDS-PAGE.
Stability : Stable for at least 6 months from date of receipt under proper storage and handling conditions.
Storage : Store at -80 centigrade.
Concentration : Protein formulated and vialed at >50 μg/mL in specified buffer
Storage Buffer : 1 x PBS
Gene Name : Pf4 platelet factor 4 [ Mus musculus (house mouse) ]
Official Symbol : Pf4
Synonyms : PF4; platelet factor 4; PF-4; C-X-C motif chemokine 4; chemokine (C-X-C motif) ligand 4; Cxcl4; Scyb4
Gene ID : 56744
mRNA Refseq : NM_019932
Protein Refseq : NP_064316
UniProt ID : Q9Z126

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Are there any therapeutic approaches targeting PF4 protein? 02/17/2023

Some research has explored the development of antibodies targeting PF4 to mitigate its pro-inflammatory effects, although such treatments are still in the early stages of investigation.

How does PF4 protein contribute to the pathogenesis of inflammation? 11/11/2022

PF4 can promote inflammation by recruiting and activating immune cells, such as monocytes and neutrophils, at the site of inflammation.

What are the potential treatment options for patients with HIT? 04/24/2017

Management often involves discontinuing heparin and initiating alternative anticoagulation strategies, such as direct thrombin inhibitors or fondaparinux.

Can PF4 protein be used as a biomarker for other conditions? 06/20/2016

Yes, elevated PF4 levels have been associated with various inflammatory states, making it a potential biomarker for certain diseases.

What diagnostic methods are used to assess PF4 protein levels? 01/30/2016

ELISA (enzyme-linked immunosorbent assay) is commonly used to detect anti-PF4/heparin antibodies in patients suspected of having HIT.

Customer Reviews (3)

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Reviews
09/07/2022

    the PF4 protein's well-documented properties and thoroughly tested functionality give me the confidence to integrate it seamlessly into my experimental setup.

    06/30/2018

      Its impeccable purity and reliability ensure accurate and reproducible results, providing a solid foundation for my research.

      12/12/2017

        he PF4 protein is an exceptional choice that meets the highest standards of quality, perfectly catering to my experimental requirements.

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