Active Recombinant Mouse Pf4 Protein
Cat.No. : | Pf4-4803M |
Product Overview : | Purified recombinant protein of Mouse platelet factor 4 (Pf4 / PF-4) without tag was expressed in E. coli. |
- Specification
- Gene Information
- Related Products
Description : | Released during platelet aggregation. Neutralizes the anticoagulant effect of heparin because it binds more strongly to heparin than to the chondroitin-4-sulfate chains of the carrier molecule. Chemotactic for neutrophils and monocytes. Inhibits endothelial cell proliferation. |
Source : | E. coli |
Species : | Mouse |
Bio-activity : | The ED50 is 3-5 μg/ml, corresponding to a specific activity 2.0-3.3 × 10^2 units/mg, determined by a dose-dependent inhibition of human FGF-basic-dependent proliferation of human umbilical vein endothelial cells (HUVEC). |
Molecular Mass : | 8.2 kDa |
Protein length : | Val30-Ser105 |
Endotoxin : | Less than 0.01 ng/μg protein as determined by the LAL method |
Purity : | > 98%, as determined by Coomassie stained SDS-PAGE. |
Stability : | Stable for at least 6 months from date of receipt under proper storage and handling conditions. |
Storage : | Store at -80 centigrade. |
Concentration : | Protein formulated and vialed at >50 μg/mL in specified buffer |
Storage Buffer : | 1 x PBS |
Gene Name : | Pf4 platelet factor 4 [ Mus musculus (house mouse) ] |
Official Symbol : | Pf4 |
Synonyms : | PF4; platelet factor 4; PF-4; C-X-C motif chemokine 4; chemokine (C-X-C motif) ligand 4; Cxcl4; Scyb4 |
Gene ID : | 56744 |
mRNA Refseq : | NM_019932 |
Protein Refseq : | NP_064316 |
UniProt ID : | Q9Z126 |
Products Types
◆ Recombinant Protein | ||
PF4-245H | Active Recombinant Human PF4 Protein (Glu32-Ser101), N-His tagged, Animal-free, Carrier-free | +Inquiry |
PF4-166P | Active Recombinant Human PF4 Protein | +Inquiry |
Pf4-4804M | Recombinant Mouse Pf4 Protein, Myc/DDK-tagged | +Inquiry |
PF4-1180C | Recombinant Cattle PF4 Protein, His-tagged | +Inquiry |
PF4-061P | Active Recombinant Human PF4 Protein (70 aa) | +Inquiry |
◆ Native Protein | ||
PF4-253H | Native Human Platelet Factor 4 | +Inquiry |
◆ Lysates | ||
PF4-3283HCL | Recombinant Human PF4 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
- Q&As
- Reviews
Q&As (5)
Ask a questionSome research has explored the development of antibodies targeting PF4 to mitigate its pro-inflammatory effects, although such treatments are still in the early stages of investigation.
PF4 can promote inflammation by recruiting and activating immune cells, such as monocytes and neutrophils, at the site of inflammation.
Management often involves discontinuing heparin and initiating alternative anticoagulation strategies, such as direct thrombin inhibitors or fondaparinux.
Yes, elevated PF4 levels have been associated with various inflammatory states, making it a potential biomarker for certain diseases.
ELISA (enzyme-linked immunosorbent assay) is commonly used to detect anti-PF4/heparin antibodies in patients suspected of having HIT.
Customer Reviews (3)
Write a reviewthe PF4 protein's well-documented properties and thoroughly tested functionality give me the confidence to integrate it seamlessly into my experimental setup.
Its impeccable purity and reliability ensure accurate and reproducible results, providing a solid foundation for my research.
he PF4 protein is an exceptional choice that meets the highest standards of quality, perfectly catering to my experimental requirements.
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