Recombinant Mouse Plekhm1 Protein, Myc/DDK-tagged
Cat.No. : | Plekhm1-4932M |
Product Overview : | Purified recombinant protein of mouse full-length pleckstrin homology domain containing, family M (with RUN domain) member 1 (Plekhm1), with C-terminal MYC/DDK tag, expressed in HEK293T cells. |
- Specification
- Gene Information
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Description : | Proposed to act as a multivalent adapter protein that regulates Rab7-dependent and HOPS complex-dependent fusion events in the endolysosomal system and couples autophagic and the endocytic trafficking pathways. Required for late stages of endolysosomal maturation, facilitating both endocytosis-mediated degradation of growth factor receptors and autophagosome clearance. Seems to be involved in the terminal maturation of autophagosomes and to mediate autophagosome-lysosome fusion Positively regulates lysosome peripheral distribution and ruffled border formation in osteoclasts May be involved in negative regulation of endocytic transport from early endosome to late endosome/lysosome implicating its association with Rab7. May have a role in sialyl-lex-mediated transduction of apoptotic signals. Involved in bone resorption |
Source : | HEK293T |
Species : | Mouse |
Tag : | Myc/DDK |
Molecular Mass : | 118.5 kDa |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Stability : | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
Storage : | Store at -80 centigrade after receiving vials. |
Concentration : | >50 μg/mL as determined by microplate BCA method |
Storage Buffer : | 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol. |
Gene Name : | Plekhm1 pleckstrin homology domain containing, family M (with RUN domain) member 1 [ Mus musculus (house mouse) ] |
Official Symbol : | Plekhm1 |
Synonyms : | PLEKHM1; pleckstrin homology domain containing, family M (with RUN domain) member 1; pleckstrin homology domain-containing family M member 1; PH domain-containing family M member 1; B2; AP162; BC038943; D330036J23Rik |
Gene ID : | 353047 |
mRNA Refseq : | NM_183034 |
Protein Refseq : | NP_898855 |
UniProt ID : | Q7TSI1 |
Products Types
◆ Recombinant Protein | ||
PLEKHM1-6841M | Recombinant Mouse PLEKHM1 Protein, His (Fc)-Avi-tagged | +Inquiry |
PLEKHM1-2106H | Recombinant Human PLEKHM1 Protein, MYC/DDK-tagged | +Inquiry |
PLEKHM1-4180R | Recombinant Rat PLEKHM1 Protein, His (Fc)-Avi-tagged | +Inquiry |
PLEKHM1-2613C | Recombinant Chicken PLEKHM1 | +Inquiry |
PLEKHM1-4520R | Recombinant Rat PLEKHM1 Protein | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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