Creative BioMart to Present at
                        BIO-Europe Spring Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953

Recombinant Mouse SMN1 Protein (1-288 aa), His-Myc-tagged

Cat.No. : SMN1-2808M
Product Overview : Recombinant Mouse SMN1 Protein (1-288 aa) is produced by Baculovirus expression system. This protein is fused with a 10xHis tag at the N-terminal and a Myc tag at the C-terminal. Research Area: Epigenetics and Nuclear Signaling. Protein Description: Full Length.
  • Specification
  • Gene Information
  • Related Products
Description : The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus. Ensures the correct splicing of U12 intron-containing genes that may be important for normal motor and proprioceptive neurons development. Also required for resolving RNA-DNA hybrids created by RNA polymerase II, that form R-loop in transcription terminal regions, an important step in proper transcription termination. May also play a role in the metabolism of small nucleolar ribonucleoprotein (snoRNPs).
Source : Baculovirus
Species : Mouse
Tag : His-Myc
Form : Tris-based buffer,50% glycerol
Molecular Mass : 35.3 kDa
Protein length : 1-288 aa
AA Sequence : MAMGSGGAGSEQEDTVLFRRGTGQS DDSDIWDDTALIKAYDKAVASFKHA LKNGDICETPDKPKGTARRKPAKKN KSQKKNATTPLKQWKVGDKCSAVWS EDGCIYPATITSIDFKRETCVVVYT GYGNREEQNLSDLLSPTCEVANSTE QNTQENESQVSTDDSEHSSRSLRSK AHSKSKAAPWTSFLPPPPPMPGSGL GPGKPGLKFNGPPPPPPLPPPPFLP CWMPPFPSGPPIIPPPPPISPDCLD DTDALGSMLISWYMSGYHTGYYMGF RQNKKEGKCSHTN
Purity : > 85% as determined by SDS-PAGE.
Notes : Repeated freezing and thawing is not recommended. Store working aliquots at 4 centigrade for up to one week.
Storage : The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20 centigrade/-80 centigrade. The shelf life of lyophilized form is 12 months at -20 centigrade/-80 centigrade.
Concentration : A hardcopy of COA will be sent along with the products. Please refer to it for detailed information.
Gene Name : Smn1 survival motor neuron 1 [ Mus musculus ]
Official Symbol : SMN1
Synonyms : SMN1; survival motor neuron 1; survival motor neuron protein; survival of motor neuron protein; Smn; Gemin1; AI849087;
Gene ID : 20595
mRNA Refseq : NM_001252629
Protein Refseq : NP_001239558
UniProt ID : P97801

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

Inquiry

  • Q&As
  • Reviews

Q&As (0)

Ask a question

Customer Reviews (0)

Write a review

Ask a Question for All SMN1 Products

Required fields are marked with *

My Review for All SMN1 Products

Required fields are marked with *

0

Inquiry Basket

cartIcon
logo

FOLLOW US

Terms and Conditions        Privacy Policy

Copyright © 2024 Creative BioMart. All Rights Reserved.

Contact Us

  • /

Stay Updated on the Latest Bioscience Trends