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Recombinant Mouse Snx1 Protein, Myc/DDK-tagged
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Cat.No. : | Snx1-6019M Optional Service: Optional requirements on this protein |
Product Overview : | Purified recombinant protein of mouse full-length sorting nexin 1 (Snx1), with C-terminal MYC/DDK tag, expressed in HEK293T cells. |
Description : | Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC). Can sense membrane curvature and has in vitro vesicle-to-membrane remodeling activity. Involved in retrograde endosome-to-TGN transport of lysosomal enzyme receptors (IGF2R, M6PR and SORT1). Plays a role in targeting ligand-activated EGFR to the lysosomes for degradation after endocytosis from the cell surface and release from the Golgi. Involvement in retromer-independent endocytic trafficking of P2RY1 and lysosomal degradation of protease-activated receptor-1/F2R. Promotes KALRN- and RHOG-dependent but retromer-independent membrane remodeling such as lamellipodium formation; the function is dependent on GEF activity of KALRN. Required for endocytosis of DRD5 upon agonist stimulation but not for basal receptor trafficking. |
Source : | HEK293T |
Species : | Mouse |
Tag : | Myc/DDK |
Molecular Mass : | 59.3 kDa |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Stability : | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
Storage : | Store at -80 centigrade after receiving vials. |
Concentration : | >50 μg/mL as determined by microplate BCA method |
Storage Buffer : | 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol. |
Gene Name : | Snx1 sorting nexin 1 [ Mus musculus (house mouse) ] |
Official Symbol : | Snx1 |
Synonyms : | SNX1; sorting nexin 1; sorting nexin-1 |
Gene ID : | 56440 |
mRNA Refseq : | NM_019727 |
Protein Refseq : | NP_062701 |
UniProt ID : | Q9WV80 |
◆ Recombinant Protein
SNX1-4202R | Recombinant Rhesus Macaque SNX1 Protein, His (Fc)-Avi-tagged | +Inquiry |
SNX1-5311R | Recombinant Rat SNX1 Protein, His (Fc)-Avi-tagged | +Inquiry |
SNX1-696C | Recombinant Cynomolgus Monkey SNX1 Protein, His (Fc)-Avi-tagged | +Inquiry |
SNX1-2717H | Recombinant Human SNX1 Protein, His-tagged | +Inquiry |
SNX1-2800H | Recombinant Human Sorting Nexin 1, His-tagged | +Inquiry |
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◆ Lysates
SNX1-1605HCL | Recombinant Human SNX1 293 Cell Lysate | +Inquiry |
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SNX1SNX5SNX3SNX12SNX25SNX33SNX4SNX9SNX8SNX10SNX11SNX15SNX16SNX17SNX20SNX6SNX24SNX27SNX32SNX13SNX14SNX18SNX31SNX7SNX21SNX2SNX22SNX29SNX19SNX30
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