Recombinant Mouse Tgfbr2 Protein, Myc/DDK-tagged

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Recombinant Mouse Tgfbr2 Protein, Myc/DDK-tagged

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Cat.No. : Tgfbr2-6393M
Product Overview : Purified recombinant protein of mouse full-length transforming growth factor, beta receptor II (Tgfbr2), with C-terminal MYC/DDK tag, expressed in HEK293T cells.
Description : Transmembrane serine/threonine kinase forming with the TGF-beta type I serine/threonine kinase receptor, TGFBR1, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFRB1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways.
Source : HEK293T
Species : Mouse
Tag : Myc/DDK
Molecular Mass : 67.6 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Storage : Store at -80 centigrade after receiving vials.
Concentration : >50 μg/mL as determined by microplate BCA method
Storage Buffer : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Gene Name : Tgfbr2 transforming growth factor, beta receptor II [ Mus musculus (house mouse) ]
Official Symbol : Tgfbr2
Synonyms : TGFBR2; transforming growth factor, beta receptor II; TGF-beta receptor type-2; TGFR-2; TGF-beta receptor II; TGF-beta receptor type II; TGF-beta type II receptor; transforming growth factor-beta receptor type II; DNIIR; RIIDN; TBR-II; AU042018; TbetaRII; TbetaR-II; 1110020H15Rik
Gene ID : 21813
mRNA Refseq : NM_009371
Protein Refseq : NP_033397
UniProt ID : Q62312
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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