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Recombinant Mouse Unc5c Protein, Myc/DDK-tagged

Cat.No. : Unc5c-6839M
Product Overview : Purified recombinant protein of mouse full-length unc-5 netrin receptor C (Unc5c), with C-terminal MYC/DDK tag, expressed in HEK293T cells.
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  • Gene Information
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Description : Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. NTN1/Netrin-1 binding might cause dissociation of UNC5C from polymerized TUBB3 in microtubules and thereby lead to increased microtubule dynamics and axon repulsion. Axon repulsion in growth cones may also be caused by its association with DCC that may trigger signaling for repulsion. Might also collaborate with DSCAM in NTN1-mediated axon repulsion independently of DCC. Also involved in corticospinal tract axon guidance independently of DCC. Involved in dorsal root ganglion axon projection towards the spinal cord. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand.
Source : HEK293T
Species : Mouse
Tag : Myc/DDK
Molecular Mass : 103.5 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Storage : Store at -80 centigrade after receiving vials.
Concentration : >50 μg/mL as determined by microplate BCA method
Storage Buffer : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Gene Name : Unc5c unc-5 netrin receptor C [ Mus musculus (house mouse) ]
Official Symbol : Unc5c
Synonyms : UNC5C; unc-5 homolog C (C. elegans); netrin receptor UNC5C; unc5 homolog 3; UNC-5 homolog 3; protein unc-5 homolog 3; protein unc-5 homolog C; rostral cerebellar malformation protein; rcm; Unc5h3; AI047720; 6030473H24; B130051O18Rik
Gene ID : 22253
mRNA Refseq : NM_009472
Protein Refseq : NP_033498
UniProt ID : O08747

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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