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Recombinant Mouse Usp13 Protein, Myc/DDK-tagged

Cat.No. : Usp13-6864M
Product Overview : Purified recombinant protein of mouse full-length ubiquitin specific peptidase 13 (isopeptidase T-3) (Usp13), with C-terminal MYC/DDK tag, expressed in HEK293T cells.
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Description : Deubiquitinase that mediates deubiquitination of target proteins such as BECN1, MITF, SKP2 and USP10 and is involved in various processes such as autophagy and endoplasmic reticulum-associated degradation (ERAD). Component of a regulatory loop that controls autophagy and p53/TP53 levels: mediates deubiquitination of BECN1, a key regulator of autophagy, leading to stabilize the PIK3C3/VPS34-containing complexes. Also deubiquitinates USP10, an essential regulator of p53/TP53 stability. In turn, PIK3C3/VPS34-containing complexes regulate USP13 stability, suggesting the existence of a regulatory system by which PIK3C3/VPS34-containing complexes regulate p53/TP53 protein levels via USP10 and USP13. Recruited by nuclear UFD1 and mediates deubiquitination of SKP2, thereby regulating endoplasmic reticulum-associated degradation (ERAD). Also regulates ERAD through the deubiquitination of UBL4A a component of the BAG6/BAT3 complex. Mediates stabilization of SIAH2 independently of deubiquitinase activity: binds ubiquitinated SIAH2 and acts by impairing SIAH2 autoubiquitination. Has a weak deubiquitinase activity in vitro and preferentially cleaves 'Lys-63'-linked polyubiquitin chains. In contrast to USP5, it is not able to mediate unanchored polyubiquitin disassembly. Able to cleave ISG15 in vitro; however, additional experiments are required to confirm such data.
Source : HEK293T
Species : Mouse
Tag : Myc/DDK
Molecular Mass : 96.7 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Storage : Store at -80 centigrade after receiving vials.
Concentration : >50 μg/mL as determined by microplate BCA method
Storage Buffer : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Gene Name : Usp13 ubiquitin specific peptidase 13 (isopeptidase T-3) [ Mus musculus (house mouse) ]
Official Symbol : Usp13
Synonyms : USP13; ubiquitin specific peptidase 13 (isopeptidase T-3); ubiquitin carboxyl-terminal hydrolase 13; ubiquitin specific protease 13 (isopeptidase T-3); ISOT3; IsoT-3; AI848077; 2700071E21Rik; MGC107670
Gene ID : 72607
mRNA Refseq : NM_001013024
Protein Refseq : NP_001013042
UniProt ID : Q5BKP2

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Can USP13 be a potential therapeutic target for neurodegenerative diseases? 02/09/2022

There is emerging research suggesting that USP13 may play a role in neurodegenerative diseases, and targeting it could be a potential avenue for therapeutic intervention.

How does USP13 interact with other proteins in cellular pathways? 07/26/2021

USP13 interacts with various proteins, forming complexes that regulate different cellular pathways. Understanding these interactions is crucial for deciphering its role in health and disease.

Are there any known genetic variations in the USP13 gene associated with disease susceptibility? 02/17/2021

Genetic variations in the USP13 gene have been studied, and certain polymorphisms may be associated with an increased risk of specific diseases. Further research is ongoing in this area.

In what other medical conditions is USP13 protein being investigated? 03/22/2019

Researchers are exploring the role of USP13 in neurodegenerative diseases, inflammatory disorders, and other conditions where ubiquitin-mediated processes play a crucial role.

How does USP13 influence cellular response to stress and DNA damage? 04/03/2016

USP13 has been found to regulate the stability of proteins involved in the DNA damage response, affecting how cells respond to stress and maintain genomic integrity.

Customer Reviews (3)

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Reviews
01/02/2023

    Its purity, integrity, and consistency ensure reliable and reproducible results, which are essential for meaningful scientific discoveries.

    06/29/2016

      Their in-depth understanding of the protein's characteristics, applications, and potential limitations allows for valuable insights and recommendations, ensuring the success of my experiments.

      04/07/2016

        Whether it's troubleshooting, protocol optimization, or general inquiries, their knowledgeable and responsive team is readily available to assist and solve any problems that may arise during the experimental process.

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