Recombinant Mouse Wdr5 Protein, MYC/DDK-tagged
Cat.No. : | Wdr5-1016M |
Product Overview : | Purified recombinant protein of full-length mouse WD repeat domain 5 (Wdr5), with C-terminal MYC/DDK tag, was expressed in HEK293T cells. |
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Description : | Contributes to histone modification (By similarity). May position the N-terminus of histone H3 for efficient trimethylation at 'Lys-4' (By similarity). As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3 (By similarity). H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation (By similarity). As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues (By similarity). May regulate osteoblasts differentiation (PubMed:11551928). In association with RBBP5 and ASH2L, stimulates the histone methyltransferase activities of KMT2A, KMT2B, KMT2C, KMT2D, SETD1A and SETD1B (By similarity). |
Source : | HEK293T |
Species : | Mouse |
Tag : | Myc&DDK |
Molecular Mass : | 36.6 kDa |
Purity : | >80% as determined by SDS-PAGE and Coomassie blue staining |
Stability : | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
Storage : | Store at -80 centigrade after receiving vials. |
Concentration : | >50 µg/mL as determined by microplate BCA method |
Storage Buffer : | 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol. |
Gene Name : | Wdr5 WD repeat domain 5 [ Mus musculus (house mouse) ] |
Official Symbol : | Wdr5 |
Synonyms : | Wdr5; WD repeat domain 5; Big; Big-3; AA408785; AA960360; 2410008O07Rik; WD repeat-containing protein 5; BMP2-induced 3-kb gene protein; WD repeat-containing protein BIG-3 |
Gene ID : | 140858 |
mRNA Refseq : | NM_080848 |
Protein Refseq : | NP_543124 |
UniProt ID : | P61965 |
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◆ Lysates | ||
WDR5-343HCL | Recombinant Human WDR5 293 Cell Lysate | +Inquiry |
WDR5-344HCL | Recombinant Human WDR5 293 Cell Lysate | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Customer Reviews (3)
Write a reviewTheir ability to accommodate the requirements of large-scale experiments and guarantee a reliable supply streamlines my research operations, eliminating any concerns related to potential shortages.
I am confident that the protein will reliably perform in my assays, providing accurate and reproducible results.
the manufacturer's supply management capabilities assure a seamless and continuous provision of the WDR5 protein.
Q&As (5)
Ask a questionYes, WDR5 has been associated with neurodevelopmental disorders, suggesting a role in non-cancerous diseases as well.
WDR5 regulates the expression of genes critical for neural development, and dysregulation can lead to developmental disorders.
Elevated levels of WDR5 in certain cancers can serve as a diagnostic marker when detected in patient samples.
Yes, there are ongoing clinical trials to test the safety and efficacy of WDR5-targeted therapies in cancer patients.
Some studies suggest a potential link between WDR5 and autoimmune diseases, but further research is needed to confirm this association.
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