Recombinant Rat Il2 Protein, His-tagged
Cat.No. : | Il2-480R |
Product Overview : | Recombinant Rat Il2 Protein(NP_446288.1)(Ala21-Gln155), fused to 6His tag at the C-terminus, was expressed in Mammalian expression system. |
- Specification
- Gene Information
- Related Products
Description : | Interleukin-2(IL-2)is a O-glycosylated four α-helix bundle cytokine that has potent stimulatory activity for antigenactivated T cells. It is expressed by CD4+ and CD8+ T cells, γδ T cells, B cells, dendritic cells, and eosinophils. Mature rat IL-2 shares 66% and 73% amino acid sequence identity with human and mouse IL-2,respectively. The receptor for IL-2 consists of three subunits that are present on the cell surface in varying preformed complexes. IL-2 is a powerful immunoregulatory lymphokine produced by T-cells in response to antigenic or mitogenic stimulation. IL-2/IL-2R signaling is required for T-cell proliferation and other fundamental functions that are essential for the immune response. IL-2 stimulates growth and differentiation of B-cells, NK cells, lymphokine-activated killer cells, monocytes, macrophages and oligodendrocytes. |
Source : | HEK293 |
Species : | Rat |
Tag : | His |
Form : | Supplied as a 0.2 μm filtered solution of 5mM NaH2PO4, 5mM Citric acid, 150mM NaCl, pH4.0. |
Molecular Mass : | 14-16kDa, reducing conditions |
Protein length : | Ala21-Gln155 |
Endotoxin : | Less than 0.1 ng/ug (1 EU/ug) as determined by LAL test. |
Purity : | Greater than 95% as determined by reducing SDS-PAGE. |
Storage : | Store at ≤-70°C, stable for 6 months after receipt. Store at ≤-70°C, stable for 3 months under sterile conditions after opening. Please minimize freeze-thaw cycles. |
Reconstitution : | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4°C before opening to recover the entire contents. |
Shipping : | The product is shipped on dry ice/polar packs. Upon receipt, store it immediately at the temperature listed below. |
Gene Name : | Il2 interleukin 2 [ Rattus norvegicus (Norway rat) ] |
Official Symbol : | Il2 |
Synonyms : | Interleukin-2; IL-2; T-cell growth factor; TCGF; Aldesleukin; IL2 |
Gene ID : | 116562 |
mRNA Refseq : | NM_053836.1 |
Protein Refseq : | NP_446288.1 |
UniProt ID : | P17108 |
Products Types
◆ Recombinant Protein | ||
IL2-41H | Recombinant Human IL2 Protein | +Inquiry |
Il2-1024G | Recombinant Guinea pig Il2 Protein, His-tagged | +Inquiry |
IL2-156M | Active Recombinant Mouse IL2 Protein | +Inquiry |
IL2-02H | Active Recombinant Human IL2 Protein (Ala21-Thr153), Biotinylated | +Inquiry |
IL2-064H | Active Recombinant Human IL2 Protein | +Inquiry |
◆ Lysates | ||
IL2-5234HCL | Recombinant Human IL2 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
- Q&As
- Reviews
Q&As (10)
Ask a questionIL2 promotes the formation of memory T-cells.
IL2 has a pro-tumorigenic role in the tumor microenvironment.
IL2 synergizes with IL-12 in a mixed cytokine environment.
IL2 upregulates the expression of PD-1 checkpoint inhibitors.
IL2 is rapidly internalized by activated T-cells.
IL2 induces M1 macrophage polarization.
IL2 increases blood-brain barrier permeability.
IL2's affinity for its receptor decreases under hypoxic conditions.
IL2's bioactivity is enhanced by glycosylation.
IL2 promotes the differentiation of Th17 cells.
Customer Reviews (3)
Write a reviewPotent in T-cell activation.
Suitable for cytokine assays.
High stability.
Ask a Question for All Il2 Products
Required fields are marked with *
My Review for All Il2 Products
Required fields are marked with *
Inquiry Basket