Recombinant Rat IL21R Protein (Met1-Pro236), MlgG Fc-tagged

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Recombinant Rat IL21R Protein (Met1-Pro236), MlgG Fc-tagged

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Cat.No. : IL21R-944R
Product Overview : Recombinant Rat IL21R Protein (Q5EBB1) (Met1-Pro236) was produced by HEK293 Cells expression system. This protein was fused with Fc region of mouse IgG at the C-terminus.
Description : Interleukin-21 receptor, also known as IL-21 receptor, IL-21R, Novel interleukin receptor, IL21R and NILR, is a single-pass type I membrane protein which belongs to the type I cytokine receptor family and Type 4 subfamily. Interleukin-21 (IL-21) belongs to a family of cytokines that bind to a composite receptor consisting of a private receptor (IL-21R) and the common cytokine receptor gamma chain ( gamma(C) ). The IL-21R is discovered as a novel member of the class-I-cytokine-receptor family and is selectively expressed in lymphoid tissues. IL-21R shows strong sequence homologies to the interleukin-4 receptor alpha chain gene (IL-4RA). The WSXWS motif of IL-21R appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding. The box 1 motif of IL-21R is required for JAK interaction and / or activation. The IL-21R is widely distributed on lympho-haematopoietic cells and IL21 impacts a number of cell types, including CD8+ memory T cells, NK cells and subsets of CD4 memory T cells. Increased IL21 production is characteristic of certain autoimmune diseases and is likely to contribute to autoantibody production as well as pathological features of autoimmune disease. The critical role of IL21 in promoting humoral immune responses makes it an important focus of potential therapeutic interventions in conditions characterised by overproduction of pathogenic autoantibodies.
Source : HEK293
Species : Rat
Tag : MlgG Fc
Predicted N Terminal : Cys 20
Form : Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Molecular Mass : The recombinant rat IL21R comprises 451 amino acids and has a predicted molecular mass of 51.4 kDa.
Protein length : Met1-Pro236
Endotoxin : < 1.0 EU per μg of the protein as determined by the LAL method
Purity : > 90 % as determined by SDS-PAGE
Stability : Samples are stable for up to twelve months from date of receipt at -70 centigrade.
Storage : Store it under sterile conditions at -20 centigrade to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution : It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 mg/ml. Centrifuge the vial at 4ºC before opening to recover the entire contents.
Shipping : In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.
Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Gene Name : Il21r interleukin 21 receptor [ Rattus norvegicus ]
Official Symbol : IL21R
Synonyms : IL21R; interleukin 21 receptor; interleukin-21 receptor; MGC108921;
Gene ID : 308977
mRNA Refseq : NM_001012469
Protein Refseq : NP_001012487
UniProt ID : Q5EBB1

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