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Angpt2

  • Official Full Name

    angiopoietin 2

  • Overview

    The protein encoded by this gene is an antagonist of angiopoietin 1 (ANGPT1) and endothelial TEK tyrosine kinase (TIE-2, TEK). The encoded protein disrupts the vascular remodeling ability of ANGPT1 and may induce endothelial cell apoptosis. Three transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
  • Synonyms

    ANGPT2; angiopoietin 2; ANG2; AGPT2; angiopoietin-2; ANG-2; Tie2-ligand; angiopoietin-2B; angiopoietin-2a;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Chromatography Reagents
  • Protein Pre-coupled Magnetic Beads
  • Canine
  • Cattle
  • Chicken
  • Cynomolgus
  • Cynomolgus, Rhesus
  • Cynomolgus/Rhesus
  • Human
  • Mouse
  • Pig
  • Rabbit
  • Rat
  • Rhesus Macaque
  • CHO
  • CHO Stable Cells
  • E.coli
  • Hamster
  • HEK293
  • Human Cell
  • In Vitro Cell Free System
  • Insect Cell
  • Mammalian cell
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Yeast
  • C
  • 6×His
  • His
  • Fc
  • Flag
  • FLAG
  • GST
  • hFc
  • Avi
  • His (Fc)
  • His|T7
  • MlgG2a Fc
  • MYC
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ANGPT2-435H Active Recombinant Human ANGPT2, Flag-tagged HEK293 Flag
Human ANGPT2-933H Active Recombinant Human ANGPT2 Protein, His-tagged Mammalian cells His Tyr19-Phe496
Human ANGPT2-158H Active Recombinant Human ANGPT2 Protein, His-tagged, Biotinylated Mammalian cells His Tyr19-Phe496
Human ANGPT2-934H Active Recombinant Human ANGPT2 Protein, His-tagged Protein, Biotinylated Mammalian cells His Tyr19-Phe496
Human ANGPT2-550H Active Recombinant Human ANGPT2 protein, His-tagged Hamster His
Human ANGPT2-200H Active Recombinant Human ANGPT2 protein, hFc-tagged HEK293 hFc Met1-Phe496
Human ANGPT2-9645H Recombinant Human ANGPT2, GST-tagged E.coli GST 357-443a.a.
Human ANGPT2-388H Recombinant Human ANGPT2 Protein, His-tagged CHO His
Human Ang-2-3456H Recombinant Human Ang-2 CHO N/A 655
Human ANGPT2-244H Active Recombinant Human ANGPT2 protein, His-tagged HEK293 His Lys275-Phe496
Human ANGPT2-551H Recombinant Human ANGPT2 protein, GST-tagged Wheat Germ GST
Human ANGPT2-3182H Active Recombinant Human ANGPT2 protein(Met1-Phe496), His-tagged HEK293 C-His Met1-Phe496
Human ANGPT2-269H Recombinant Human ANGPT2, His-tagged, Biotinylated HEK293 His
Human ANGPT2-116H Recombinant Human Angiopoietin 2, Myc-tagged Insect Cell MYC
Human ANGPT2-531H Recombinant Human ANGPT2 protein, His-tagged E.coli His Lys24~Leu165
Human ANGPT2-532H Recombinant Human ANGPT2 protein, His-tagged E.coli His Lys269~Phe496 (Accession # O15123)
Human ANGPT2-55H Recombinant Human ANGPT2 Yeast N/A
Human ANGPT2-2228HCL Recombinant Human ANGPT2 cell lysate Human Cell N/A
Human ANGPT2-245H Recombinant Human ANGPT2(Lys275-Phe496) Protein, C-6*His-tagged HEK293 His
Human ANGPT2-6743M Active ANGPT2 protein-coupled magnetic Beads HEK293 Lys 275 - Phe 496
Human ANGPT2-34H Recombinant Human ANGPT2 Protein, N-FLAG-tagged HEK293 FLAG
Human ANGPT2-152H Recombinant Human ANGPT2 Protein, His-tagged E.coli N-His Lys24-Phe496
Human ANGPT2-1034HF Recombinant Full Length Human ANGPT2 Protein, GST-tagged In Vitro Cell Free System GST 496 amino acids
Human ANGPT2-2467H Recombinant Human ANGPT2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human ANGPT2-2467H-B Recombinant Human ANGPT2 Protein Pre-coupled Magnetic Beads HEK293
Human ANGPT2-524HB Active Recombinant Human ANGPT2 protein, His & Avi-tagged, Biotinylated HEK293 His & Avi Lys275-Phe496
Human ANGPT2-484H Recombinant Human ANGPT2 Protein 496
Human ANGPT2-6523H Recombinant Human ANGPT2 Protein, His-Avi-tagged HEK293 His-Avi Lys 275-Phe 496
Human ANGPT2-696H Recombinant Human ANGPT2 Protein, His-tagged CHO His 19-496 aa
Human ANGPT2-415H Active Recombinant Human ANGPT2 Protein (Met1-Phe496), His-tagged CHO His Met1-Phe496
Human ANGPT2-2888H Recombinant Human ANGPT2 protein, His-tagged, FITC-Labeled HEK293 His Lys 275-Phe 496
Human ANGPT2-5226H Recombinant Human ANGPT2 protein, His-tagged E.coli His 19-485aa
Human ANGPT2-1067H Recombinant Human ANGPT2 Protein (Met1-Gln248 and Lys275-Phe496), MlgG2a Fc-tagged HEK293 MlgG2a Fc Met1-Gln248 and Lys275-Phe496
Human ANGPT2-523HB Recombinant Human ANGPT2 protein, His-Avi-tagged, Biotinylated HEK293 His-Avi It contains Lys 275 - Phe 496
Human ANGPT2-0476H Recombinant Human ANGPT2 Protein (Lys24-Leu165), His-tagged E.coli His Lys24-Leu165
Human ANGPT2-5342H Recombinant Human ANGPT2 protein, His-tagged Yeast His 19-485aa
Human ANGPT2-3075H Recombinant Human ANGPT2 protein, His-tagged E.coli His 174-318 aa
Human ANGPT2-415HB Recombinant Human ANGPT2 protein, His-tagged, Biotinylated CHO Stable Cells His
Human ANGPT2-2711H Recombinant Human ANGPT2 Protein (Met1-Phe496), C-His tagged Mammalian cells C-His Met1-Phe496
Mouse Angpt2-587M Active Recombinant Mouse Angpt2 Protein, His-tagged CHO His Met1-Phe496
Mouse Angpt2-476M Active Recombinant Mouse Angpt2 protein, His-tagged HEK293 His Tyr 19 - Phe 496
Mouse Angpt2-2163M Active Recombinant Mouse Angpt2 Protein, C-6×His tagged CHO C-6×His
Mouse Angpt2-475M Recombinant Mouse Angpt2, His-tagged Human Cell His Lys275-Phe496
Mouse Angpt2-88M Recombinant Mouse Angpt2, FLAG-tagged HEK293 Flag
Mouse Angpt2-533M Recombinant Mouse Angpt2 protein, His-tagged E.coli His Tyr19~Ala147 (Accession # O15123)
Mouse ANGPT2-001MCL Recombinant Mouse ANGPT2 cell lysate Human Cell N/A
Mouse Angpt2-477M Recombinant Mouse Angpt2(Tyr19-Phe496) Protein, C-Fc-tagged HEK293 Fc
Mouse Angpt2-5309M Recombinant Mouse Angpt2 protein, His-tagged E.coli His 19-483aa
Rat Angpt2-535R Recombinant Rat Angpt2 protein, His-tagged E.coli His Gln33~Val243 (Accession # O35462)
Rat ANGPT2-669R Active Recombinant Rat ANGPT2 protein, His-tagged HEK293 His Lys 275 - Phe 496
Rat Angpt2-536R Recombinant Rat Angpt2 protein, His-tagged E.coli His Glu352~Trp477 (Accession # O35462)
Rat ANGPT2-325R-B Recombinant Rat ANGPT2 Protein Pre-coupled Magnetic Beads HEK293
Rat ANGPT2-325R Recombinant Rat ANGPT2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rabbit ANGPT2-537R Recombinant Rabbit ANGPT2 protein, His-tagged E.coli His Leu230~Thr487
Rabbit ANGPT2-27R Recombinant Rabbit ANGPT2 Protein (19-496), C-6×His-tagged HEK293 C-6×His 19-496
Rabbit ANGPT2-315R Active Recombinant Rabbit ANGPT2 protein, His-tagged HEK293 His Lys 275 - Phe 496
Canine ANGPT2-1040C Active Recombinant Canine ANGPT2 protein(Lys274-Phe495), His-tagged HEK293 N-His Lys274-Phe495
Cattle ANGPT2-530C Recombinant Cattle ANGPT2 protein, His-tagged E.coli His Gln1~Pro123 (Accession # P80929)
Cynomolgus ANGPT2-1173C Active Recombinant Cynomolgus ANGPT2 Protein, His-tagged HEK293 His
Cynomolgus, Rhesus ANGPT2-1174C Recombinant Cynomolgus/Rhesus ANGPT2 protein (Met1-Phe495), His-tagged HEK293 His
Cynomolgus/Rhesus ANGPT2-1172C Active Recombinant Cynomolgus/Rhesus ANGPT2 protein, hFc-tagged HEK293 hFc Lys274-Phe495
Cynomolgus/Rhesus ANGPT2-2167C Active Recombinant Cynomolgus/Rhesus ANGPT2 protein, His-tagged HEK293 His Lys274-Phe495
Rhesus Macaque ANGPT2-1175C Recombinant Rhesus Macaque ANGPT2(Tyr19-Phe495) Protein, C-Fc-tagged HEK293 Fc
Pig ANGPT2-534P Recombinant Pig ANGPT2 protein, His & T7-tagged E.coli His/T7 Asn89~Leu206 (Accession # Q9BDY7)
Pig ANGPT2-28P Recombinant Pig ANGPT2 Protein, His tagged HEK293 N-His
Pig ANGPT2-01P Recombinant Pig ANGPT2 Protein, N-His tagged Mammalian cell N-His
Chicken ANGPT2-6380C Recombinant Chicken ANGPT2 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Angpt2 Related Articles
  • Angpt2 Related Research Area

Angpt2 involved in several pathways and played different roles in them. We selected most pathways Angpt2 participated on our site, such as Ras signaling pathway, Rap signaling pathway, HIF- signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with Angpt2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Ras signaling pathwayFGF20;RAP1B;GNB1;RAC3;PLA2G2E;SHC2;PRKCG;TEK;PIK3CA
Rap signaling pathwayPARD6A;INS2;PRKD3;Fgf15;ANGPT4;ITGAL;IGF1;PRKCB;RAC3
HIF- signaling pathwayPDHA2;VEGFA;EPO;PLCG1;MKNK1;CAMK2B;TF;ENO2;ARNT
PIK-Akt signaling pathwayKRAS;KIT;IRS1;GRB2;TP53;PHLPP2;PIK3CD;IFNAR1;HSP90B1

Angpt2 has several biochemical functions, for example, metal ion binding, protein binding, receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Angpt2 itself. We selected most functions Angpt2 had, and list some proteins which have the same functions with Angpt2. You can find most of the proteins on our site.

Function Related Protein
metal ion bindingMGAT4C;ATP13A3;CSGALNACT2;ZMYND12;DPYDB;AMPD2;TRIM35-29;PCGF5B;LMO4B
protein bindingKCTD9;AQP5;CTTNBP2NL;ALDH3B1;LARP2;EXOSC2;POLR1D;KIRREL;FAM113B
receptor bindingNPFF;DIAPH1;MSTN;NPPC;F7;ARRB2;NUDT7;DAO;CNPY4
receptor tyrosine kinase bindingPLCG1;ELMO2;PTPN1;MYOC;FLT3LG;NRG1;Flt3l;DNAJA3;FIZ1

Angpt2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Angpt2 here. Most of them are supplied by our site. Hope this information will be useful for your research of Angpt2.

daap-5; TEK; daap-4; VEGFA; ANXA7; CDKN1A; CSNK2B; IQCB1

Rigamonti, N; Kadioglu, E; et al. Role of Angiopoietin-2 in Adaptive Tumor Resistance to VEGF Signaling Blockade. CELL REPORTS 8:696-706(2014).
D'Amico, G; Korhonen, EA; et al. Tie1 deletion inhibits tumor growth and improves angiopoietin antagonist therapy. JOURNAL OF CLINICAL INVESTIGATION 124:824-834(2014).
  • Q&As
  • Reviews

Q&As (15)

Ask a question
Are there any potential side effects or risks associated with ANGPT2 inhibitors? 12/14/2022

Like any other therapeutic agent, ANGPT2 inhibitors may have side effects and risks. Common side effects reported in clinical trials include fatigue, headache, gastrointestinal disturbances, and hypertension. However, the specific side effects and risks may vary depending on the individual drug and its mechanism of action. It is important to consult with healthcare professionals and closely monitor patients during treatment to manage any potential adverse effects.

Can ANGPT2 inhibitors be used in combination with other therapies? 06/14/2022

Yes, ANGPT2 inhibitors can be used in combination with other therapies. Combining ANGPT2 inhibitors with other anti-angiogenic agents, chemotherapy, or immunotherapy may have synergistic effects and enhance treatment outcomes. Additionally, they may be combined with conventional treatments in diseases where ANGPT2 is implicated in disease progression or resistance to therapy. Clinical trials are ongoing to evaluate the safety and efficacy of these combination therapies.

Are there any inhibitors or activators of ANGPT2? 04/21/2021

Several compounds have been identified as inhibitors of ANGPT2. These include antibodies that specifically target ANGPT2, as well as small molecule inhibitors that interfere with its activity. In contrast, there are no known activators of ANGPT2 identified to date.

Are there natural compounds or dietary factors that can modulate ANGPT2 levels? 02/19/2020

Some studies suggest that certain natural compounds or dietary factors can modulate ANGPT2 levels. For example, green tea catechins, resveratrol, and curcumin have demonstrated potential in reducing ANGPT2 expression or activity in preclinical studies. However, more research is needed to determine their efficacy and safety in clinical settings.

Are there any genetic or epigenetic factors that regulate ANGPT2 expression? 08/13/2019

Yes, ANGPT2 expression is regulated by various genetic and epigenetic factors. Single nucleotide polymorphisms (SNPs) in the ANGPT2 gene have been associated with altered ANGPT2 expression levels and susceptibility to certain diseases. Additionally, epigenetic modifications, such as DNA methylation and histone modifications, can also regulate ANGPT2 expression by influencing the accessibility of the gene for transcription.

What are the challenges and future directions in the development and use of ANGPT2 inhibitors? 05/27/2019

One of the challenges in the development and use of ANGPT2 inhibitors is identifying the patient populations that would benefit most from this therapy. Understanding the precise mechanisms of ANGPT2 in different diseases and identifying reliable biomarkers for patient selection are important areas of future research.

What are the potential therapeutic applications of ANGPT2 inhibitors? 03/25/2019

ANGPT2 inhibitors have shown promise in various therapeutic applications. In cancer, blocking ANGPT2 can help normalize tumor blood vessels, improve drug delivery to the tumor, and enhance the effectiveness of anti-cancer therapies. Additionally, ANGPT2 inhibitors may also have potential in the treatment of other diseases involving abnormal angiogenesis, such as age-related macular degeneration, diabetic retinopathy, and inflammatory disorders.

What role does ANGPT2 play in cancer? 10/19/2018

In cancer, ANGPT2 is often upregulated and contributes to tumor angiogenesis and progression. It promotes vessel destabilization, allowing for the formation of leaky and irregular blood vessels within tumors. This abnormal vasculature can support tumor growth, metastasis, and resistance to therapies.

Are there ongoing clinical trials targeting ANGPT2 in cancer or other diseases? 07/05/2018

Yes, there are ongoing clinical trials investigating the therapeutic potential of targeting ANGPT2 in cancer and other diseases. These trials evaluate the efficacy and safety of ANGPT2 inhibitors either alone or in combination with other treatments. These studies aim to elucidate whether blocking ANGPT2 can have clinical benefits, such as inhibiting tumor growth, improving patient outcomes, or overcoming therapy resistance.

Can ANGPT2 be used as a biomarker in diseases? 06/15/2018

ANGPT2 has been explored as a potential biomarker in various diseases, including cancer, cardiovascular diseases, and sepsis. Elevated levels of ANGPT2 have been associated with disease progression and poor prognosis in some cases. However, further research is still needed to establish its clinical utility as a diagnostic or prognostic biomarker.

How is ANGPT2 involved in inflammation and immune responses? 08/15/2017

ANGPT2 plays a role in inflammation and immune responses by promoting vascular leakiness and enhancing the recruitment of immune cells to the site of inflammation. It is produced by immune cells, such as macrophages and neutrophils, in response to inflammatory stimuli. ANGPT2 can disrupt endothelial integrity, facilitating the extravasation of immune cells and contributing to the inflammatory process.

Are there any therapeutic strategies aimed at restoring the balance between ANGPT1 and ANGPT2? 05/07/2017

Yes, some therapeutic strategies aim to restore the balance between ANGPT1 and ANGPT2. These strategies include the administration of exogenous ANGPT1 or ANGPT2 inhibitors to regulate angiogenesis and vascular stability. The goal is to promote a more balanced and controlled angiogenic response, which may have therapeutic benefits in various diseases characterized by aberrant angiogenesis.

Are there any ongoing clinical trials investigating the use of ANGPT2 inhibitors in different diseases? 10/25/2016

Yes, there are several ongoing clinical trials investigating the use of ANGPT2 inhibitors in various diseases. These trials assess the safety, efficacy, and optimal dosing of ANGPT2 inhibitors either as monotherapy or in combination with other treatments. Some of the diseases being studied include solid tumors, diabetic macular edema, acute myeloid leukemia, and idiopathic pulmonary fibrosis, among others. These trials aim to determine the potential of ANGPT2 inhibitors as a therapeutic option in these diseases.

How do ANGPT2 inhibitors compare to other anti-angiogenic therapies? 08/25/2016

ANGPT2 inhibitors function as anti-angiogenic agents by blocking the activation of ANGPT2 and its interaction with the Tie2 receptor. Compared to other anti-angiogenic therapies, such as VEGF inhibitors, ANGPT2 inhibitors target a different pathway involved in angiogenesis regulation.

Where is ANGPT2 produced? 04/19/2016

ANGPT2 is produced by various cell types, including endothelial cells, immune cells, and certain cancer cells. Its production can be induced by different stimuli, such as hypoxia, inflammation, and growth factors.

Customer Reviews (5)

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Reviews
12/13/2020

    The ANGPT2 protein offers exceptional quality that meets the rigorous demands of experimental research.

    08/14/2020

      Whether studying angiopoietin signaling pathways, vascular remodeling, or endothelial cell biology, the ANGPT2 protein is an invaluable tool for researchers.

      05/15/2020

        What sets the ANGPT2 protein apart is not only its outstanding quality but also the excellent technical support provided by the manufacturer.

        08/18/2017

          the ANGPT2 protein's versatility extends beyond its proven usefulness in in vitro experiments.

          05/29/2016

            Its purity, consistency, and reliable performance make it a top choice for a wide range of applications.

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