angpt2
Share
  • Official Full Name
  • angiopoietin 2
  • Background
  • The protein encoded by this gene is an antagonist of angiopoietin 1 (ANGPT1) and endothelial TEK tyrosine kinase (TIE-2, TEK). The encoded protein disrupts the vascular remodeling ability of ANGPT1 and may induce endothelial cell apoptosis. Three transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
  • Synonyms
  • ANGPT2; angiopoietin 2; ANG2; AGPT2; angiopoietin-2; ANG-2; Tie2-ligand; angiopoietin-2B; angiopoietin-2a
Cat.#:ANGPT2-116HTag:MYC
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human Angiopoietin 2, Myc-tagged
+Inquiry
Cat.#:Angpt2-2163MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse Angiopoietin 2, His-tagged
+Inquiry
Cat.#:Ang-2-3456HTag:
Source (Host):CHOSpecies:Human
Product nameRecombinant Human Ang-2
+Inquiry
Cat.#:ANGPT2-158HTag:His
Source (Host):NS0Species:Human
Product nameRecombinant Human ANGPT2 Protein, His-tagged, Biotinylated
+Inquiry
Cat.#:ANGPT2-200HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human ANGPT2, Fc tagged
+Inquiry
Cat.#:ANGPT2-244HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human ANGPT2 Protein, His-tagged
+Inquiry
Cat.#:ANGPT2-269HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human ANGPT2, His-tagged, Biotinylated
+Inquiry
Cat.#:ANGPT2-3182HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human ANGPT2, His tagged
+Inquiry
Cat.#:ANGPT2-388HTag:His
Source (Host):CHO cellsSpecies:Human
Product nameRecombinant Human ANGPT2 Protein, His-tagged
+Inquiry
Cat.#:ANGPT2-435HTag:Flag
Source (Host):HEK293Species:Human
Product nameRecombinant Human ANGPT2, Flag-tagged
+Inquiry
Cat.#:ANGPT2-531HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ANGPT2 protein, His-tagged
+Inquiry
Cat.#:ANGPT2-532HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ANGPT2 protein, His-tagged
+Inquiry
Cat.#:ANGPT2-550HTag:His
Source (Host):HamsterSpecies:Human
Product nameRecombinant Human ANGPT2 protein, His-tagged
+Inquiry
Cat.#:ANGPT2-551HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human ANGPT2 protein, GST-tagged
+Inquiry
Cat.#:ANGPT2-55HTag:
Source (Host):YeastSpecies:Human
Product nameRecombinant Human ANGPT2
+Inquiry
Cat.#:ANGPT2-933HTag:His
Source (Host):NSO CellsSpecies:Human
Product nameRecombinant Human ANGPT2 Protein, His-tagged
+Inquiry
Cat.#:ANGPT2-934HTag:His
Source (Host):NSO CellsSpecies:Human
Product nameRecombinant Human ANGPT2 Protein, His-tagged Protein, Biotinylated
+Inquiry
Cat.#:ANGPT2-9645HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ANGPT2, GST-tagged
+Inquiry
Cat.#:Angpt2-475MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Angpt2, His-tagged
+Inquiry
Cat.#:Angpt2-533MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Angpt2 protein, His-tagged
+Inquiry
Cat.#:Angpt2-587MTag:His
Source (Host):CHO CellsSpecies:Mouse
Product nameRecombinant Mouse Angpt2 Protein, His-tagged
+Inquiry
Cat.#:Angpt2-88MTag:Flag
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Angpt2, FLAG-tagged
+Inquiry
Cat.#:Angpt2-535RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Angpt2 protein, His-tagged
+Inquiry
Cat.#:Angpt2-536RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Angpt2 protein, His-tagged
+Inquiry
Cat.#:ANGPT2-669RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat ANGPT2 Protein
+Inquiry
Cat.#:ANGPT2-1172CTag:Fc
Source (Host):HEK293Species:Cynomolgus Monkey
Product nameRecombinant Cynomolgus ANGPT2 Protein, Fc-tagged
+Inquiry
Cat.#:ANGPT2-1173CTag:His
Source (Host):HEK293Species:Cynomolgus Monkey
Product nameRecombinant Cynomolgus ANGPT2 Protein, His-tagged
+Inquiry
Cat.#:ANGPT2-1040CTag:His
Source (Host):HEK293Species:Canine
Product nameRecombinant Canine ANGPT2 Protein, His-tagged
+Inquiry
Cat.#:ANGPT2-537RTag:His
Source (Host):E. coliSpecies:Rabbit
Product nameRecombinant Rabbit ANGPT2 protein, His-tagged
+Inquiry
Cat.#:ANGPT2-6380CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken ANGPT2
+Inquiry
Cat.#:ANGPT2-530CTag:His
Source (Host):E. coliSpecies:Cattle
Product nameRecombinant Cattle ANGPT2 protein, His-tagged
+Inquiry
Cat.#:ANGPT2-534PTag:His/T7
Source (Host):E. coliSpecies:Pig
Product nameRecombinant Pig ANGPT2 protein, His & T7-tagged
+Inquiry
Cat.#:ANGPT2-2228HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human ANGPT2 cell lysate
+Inquiry
Cat.#:ANGPT2-001MCLTag:
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse ANGPT2 cell lysate
+Inquiry

Involved Pathway

Angpt2 involved in several pathways and played different roles in them. We selected most pathways Angpt2 participated on our site, such as Ras signaling pathway, Rap signaling pathway, HIF- signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with Angpt2 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Ras signaling pathway
Kitl; PLA2G6; MAP2K1; PRKCG; KSR2; PLA2G12B; CALM3; RRAS2; SHC2; Fasl
Rap signaling pathway
INS; FGF12; FGF10; HGF; FARP2; PDGFRB; ANGPT2; MAP2K6; GRIN2A; PLCE1
HIF- signaling pathway
IFNG; RPS6KB2; PGK1; LDHA; PIK3R2; PIK3R5; IL6R; PDHA2; PIK3R1; TF
PIK-Akt signaling pathway
ITGAV; PDGFRA; PDPK1; GNB2; FLT4; MAPK1; SPP1; IL7; ITGB3; LAMC2

Protein Function

Angpt2 has several biochemical functions, for example, metal ion binding, protein binding, receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Angpt2 itself. We selected most functions Angpt2 had, and list some proteins which have the same functions with Angpt2. You can find most of the proteins on our site.
Function
Related Protein
Function metal ion binding
Related Protein TNNI3; ZNF701; ITGA10; DTD1; SALL3B; GLIS2; STEAP1; ZFP82; POLR2B; ZFP239
Function protein binding
Related Protein MORN4; ITPR3; LGI1; EDNRB; CCDC155; PSMB4; Tnfrsf23; NDNL2; IFNA2; FES
Function receptor binding
Related Protein AGRP2; Itga10&Itgb1; WNT7AA; CXCL12; CNPY4; Artn; KCNA5; FGF18A; LPL; CNTFR
Function receptor tyrosine kinase binding
Related Protein SQSTM1; PITPNM3; NRG3; FIZ1; CPNE3; ZFP259; ZNF259; PTPN11; SOCS5; SHC4

Interacting Protein

Angpt2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Angpt2 here. Most of them are supplied by our site. Hope this information will be useful for your research of Angpt2.
daap-5; TEK; daap-4; VEGFA; ANXA7; CDKN1A; CSNK2B; IQCB1

Angpt2 Related Articles

Rigamonti, N; Kadioglu, E; et al. Role of Angiopoietin-2 in Adaptive Tumor Resistance to VEGF Signaling Blockade. CELL REPORTS 8:696-706(2014).
D'Amico, G; Korhonen, EA; et al. Tie1 deletion inhibits tumor growth and improves angiopoietin antagonist therapy. JOURNAL OF CLINICAL INVESTIGATION 124:824-834(2014).