CD22 Protein, CD22 molecule

CD22

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CD22

Official Full Name CD22 molecule
Background CD22 or cluster of differentiation-22, is a molecule belonging to the SIGLEC family of lectins.[1] It is found on the surface of mature B cells and to a lesser extent on some immature B cells. Generally speaking, CD22 is a regulatory molecule that prevents the overactivation of the immune system and the development of autoimmune diseases.
Synonyms SIGLEC2; SIGLEC-2; B-cell receptor CD22; BL-CAM; CD22 antigen; T-cell surface antigen Leu-14; B-lymphocyte cell adhesion molecule; sialic acid binding Ig-like lectin 2; sialic acid-binding Ig-like lectin 2; BLCAM; Leu14; Siglec-2; Bectumomab; LymphoScan; 158318-63-9; Epratuzumab; 205923-57-5; Moxetumomab pasudotox; 1020748-57-5; Inotuzumab ozogamicin; 635715-01-4
    • Species :
    • Human
    • Mouse
    • Rat
    • Rhesus
    • Rhesus macaque
    • Zebrafish
    • Source :
    • CHO
    • E.coli
    • HEK293
    • Human Cell
    • Insect Cell
    • Mammalian Cell
    • NS0
    • Tag :
    • Avi
    • Fc
    • Fc Chimera
    • His
    • LIgG2b Fc
    • N/A
    • Strep II
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Rat Cd22-1153RA Recombinant Rat Cd22 protein, Fc-tagged, APC labeled HEK293 Fc
    Rat Cd22-1153RP Recombinant Rat Cd22 protein, Fc-tagged, R-PE labeled HEK293 Fc
    Human CD22-333H Recombinant Human CD22 Protein, LIgG2b Fc-tagged, low endotoxin HEK293 LIgG2b Fc
    Human CD22-334H Recombinant Human CD22 Protein, Fc & Avi-tagged, Biotinylated HEK293 Avi/Fc
    Human CD22-335H Recombinant Human CD22 Protein (Asp 20 - Arg 687), His-tagged, FITC-Labeled HEK293 His
    Mouse CD22-336M Recombinant Mouse CD22 protein, His-tagged HEK293 His
    Human CD22-3947HA Recombinant Human CD22 protein, His-tagged, APC labeled HEK293 His
    Human CD22-3947HP Recombinant Human CD22 protein, His-tagged, R-PE labeled HEK293 His
    Human CD22-482HA Recombinant Human CD22 protein, Fc-tagged, APC labeled NS0 Fc
    Human CD22-482HP Recombinant Human CD22 protein, Fc-tagged, R-PE labeled NS0 Fc
    Human CD22-532H Recombinant Human CD22 Protein (Trp176-Arg687), His-tagged, Biotinylated Insect Cell His
    Human CD22-533H Recombinant Human CD22 Protein (Met1-Arg687) (ECD) HEK293 N/A
    Human CD22-561HA Recombinant Human CD22 protein, Fc-tagged, APC labeled HEK293 Fc
    Human CD22-561HP Recombinant Human CD22 protein, Fc-tagged, R-PE labeled HEK293 Fc
    Human CD22-562HA Recombinant Human CD22 protein, Fc-tagged, APC labeled HEK293 Fc
    Human CD22-562HP Recombinant Human CD22 protein, Fc-tagged, R-PE labeled HEK293 Fc
    Rhesus CD22-8854CA Recombinant Rhesus CD22 protein, Fc-tagged, APC labeled HEK293 Fc
    Rhesus CD22-8854CP Recombinant Rhesus CD22 protein, Fc-tagged, R-PE labeled HEK293 Fc
    Human CD22-10926H Recombinant Human CD22, His-tagged E.coli His
    Human CD22-1956HCL Recombinant Human CD22 cell lysate Human Cell N/A
    Human CD22-246H Recombinant Human CD22, StrepII-tagged Human Cell Strep II
    Human CD22-27297TH Recombinant Human CD22 CHO N/A
    Human CD22-3946H Recombinant Human CD22, His tagged Human Cell His
    Human CD22-3947H Recombinant Human CD22 Protein, His-tagged HEK293 His
    Human CD22-482H Recombinant Human CD22, Fc Chimera NS0 Fc Chimera
    Human CD22-559H Recombinant Human CD22, His-tagged, Biotinylated Human Cell His
    Human CD22-560H Recombinant Human CD22, Fc-tagged, Biotinylated Human Cell Fc
    Human CD22-561H Recombinant Human CD22, Fc-tagged Human Cell Fc
    Human CD22-562H Recombinant Human CD22 protein, Fc-tagged HEK293 Fc
    Human CD22-960H Recombinant Human CD22 Molecule, Extracellular Domain CHO N/A
    Mouse CD22-001MCL Recombinant Mouse CD22 cell lysate Human Cell N/A
    Mouse CD22-179M Recombinant Mouse Cd22, Fc tagged Human Cell His
    Mouse Cd22-535M Recombinant Mouse Cd22, His-tagged Human Cell His
    Rat Cd22-1153R Recombinant Rat Cd22 Protein, Fc-tagged HEK293 Fc
    Rat Cd22-1154R Recombinant Rat Cd22 Protein, His-tagged HEK293 His
    Rhesus macaque CD22-1212R Recombinant Rhesus macaque CD22 protein, His-tagged HEK293 His
    Rhesus Macaque CD22-8854C Recombinant Rhesus CD22 protein, Fc-tagged HEK293 Fc
    Zebrafish CD22-5443Z Recombinant Zebrafish CD22 Mammalian Cell His

    CD22 involved in several pathways and played different roles in them. We selected most pathways CD22 participated on our site, such as Cell adhesion molecules (CAMs), Hematopoietic cell lineage, B cell receptor signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CD22 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cell adhesion molecules (CAMs) CADM1B; CLDNF; SELPLG; NRXN3; CDH2; BF2; HLA-A; CADM1; CLDN1; MHC2A
    Hematopoietic cell lineage CD1d1; Fcer2a; IL11; CD59; IL1R2; ITGA2B; EPO; CSF1R; CD1B; GP1BB
    B cell receptor signaling pathway STAP1; CDK2; RELA; PDK2; RAF1; CR2; CD79A; ITPR2; GRB2; CDK6

    CD22 has several biochemical functions, for example, carbohydrate binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CD22 itself. We selected most functions CD22 had, and list some proteins which have the same functions with CD22. You can find most of the proteins on our site.

    Function Related Protein
    carbohydrate binding REG1A; CD33; CLEC5A; CHI3L1; SIGLEC7; CLEC7A; Siglec1; POC1BL; KLRD1; MAN2A2
    protein binding AP5S1; ZNF3; DCLRE1C; LARP4; GATA6; GABARAPL2; TSPO; PRPF4B; FRA10AC1; RSU1

    CD22 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CD22 here. Most of them are supplied by our site. Hope this information will be useful for your research of CD22.

    SYK; LYN; PLCG1; PTPN6; PTPRC; cpxA; PIK3R1

    Lv, W; Duan, QL; et al. Expression of B-cell-associated genes in peripheral blood mononuclear cells of patients with symptomatic pulmonary embolism. MOLECULAR MEDICINE REPORTS 11:2299-2305(2015).
    Jabbour, E; O'Brien, S; et al. Prognostic factors for outcome in patients with refractory and relapsed acute lymphocytic leukemia treated with inotuzumab ozogamicin, a CD22 monoclonal antibody. AMERICAN JOURNAL OF HEMATOLOGY 90:193-196(2015).

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