cd22
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  • Official Full Name
  • CD22 molecule
  • Background
  • CD22 or cluster of differentiation-22, is a molecule belonging to the SIGLEC family of lectins.[1] It is found on the surface of mature B cells and to a lesser extent on some immature B cells. Generally speaking, CD22 is a regulatory molecule that prevents the overactivation of the immune system and the development of autoimmune diseases.
  • Synonyms
  • SIGLEC2; SIGLEC-2; B-cell receptor CD22; BL-CAM; CD22 antigen; T-cell surface antigen Leu-14; B-lymphocyte cell adhesion molecule; sialic acid binding Ig-like lectin 2; sialic acid-binding Ig-like lectin 2; BLCAM; Leu14; Siglec-2; Bectumomab; LymphoScan; 158318-63-9; Epratuzumab; 205923-57-5; Moxetumomab pasudotox; 1020748-57-5; Inotuzumab ozogamicin; 635715-01-4
Cat.#:Cd22-1153RATag:Fc
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat Cd22 protein, Fc-tagged, APC labeled
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Cat.#:Cd22-1153RPTag:Fc
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat Cd22 protein, Fc-tagged, R-PE labeled
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Cat.#:CD22-333HTag:LIgG2b Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human CD22 Protein, LIgG2b Fc-tagged, low endotoxin
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Cat.#:CD22-334HTag:Fc/Avi
Source (Host):HEK293Species:Human
Product nameRecombinant Human CD22 Protein, Fc & Avi-tagged, Biotinylated
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Cat.#:CD22-335HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human CD22 Protein (Asp 20 - Arg 687), His-tagged, FITC-Labeled
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Cat.#:CD22-336MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse CD22 Protein, His-tagged
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Cat.#:CD22-3947HATag:His
Source (Host):HEK293 CellsSpecies:Human
Product nameRecombinant Human CD22 protein, His-tagged, APC labeled
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Cat.#:CD22-3947HPTag:His
Source (Host):HEK293 CellsSpecies:Human
Product nameRecombinant Human CD22 protein, His-tagged, R-PE labeled
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Cat.#:CD22-482HATag:Fc
Source (Host):NS0 CellsSpecies:Human
Product nameRecombinant Human CD22 protein, Fc-tagged, APC labeled
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Cat.#:CD22-482HPTag:Fc
Source (Host):NS0 CellsSpecies:Human
Product nameRecombinant Human CD22 protein, Fc-tagged, R-PE labeled
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Cat.#:CD22-532HTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human CD22 Protein (Trp176-Arg687), His-tagged, Biotinylated
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Cat.#:CD22-533HTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human CD22 Protein (Met1-Arg687) (ECD)
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Cat.#:CD22-561HATag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human CD22 protein, Fc-tagged, APC labeled
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Cat.#:CD22-561HPTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human CD22 protein, Fc-tagged, R-PE labeled
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Cat.#:CD22-562HATag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human CD22 protein, Fc-tagged, APC labeled
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Cat.#:CD22-562HPTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human CD22 protein, Fc-tagged, R-PE labeled
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Cat.#:CD22-8854CATag:Fc
Source (Host):HEK293Species:Rhesus
Product nameRecombinant Rhesus CD22 protein, Fc-tagged, APC labeled
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Cat.#:CD22-8854CPTag:Fc
Source (Host):HEK293Species:Rhesus
Product nameRecombinant Rhesus CD22 protein, Fc-tagged, R-PE labeled
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Cat.#:CD22-3947HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human CD22 Protein, His-tagged
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Cat.#:CD22-10926HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CD22, His-tagged
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Cat.#:CD22-246HTag:Strep II
Source (Host):HEK293Species:Human
Product nameRecombinant Human CD22, StrepII-tagged
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Cat.#:CD22-27297THTag:
Source (Host):CHOSpecies:Human
Product nameRecombinant Human CD22
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Cat.#:CD22-3946HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human CD22, His tagged
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Cat.#:CD22-482HTag:Fc Chimera
Source (Host):NSO cellsSpecies:Human
Product nameRecombinant Human CD22, Fc Chimera
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Cat.#:CD22-559HTag:His
Source (Host):Human cellsSpecies:Human
Product nameRecombinant Human CD22, His-tagged, Biotinylated
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Cat.#:CD22-560HTag:Fc
Source (Host):Human cellsSpecies:Human
Product nameRecombinant Human CD22, Fc-tagged, Biotinylated
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Cat.#:CD22-561HTag:Fc
Source (Host):Human cellsSpecies:Human
Product nameRecombinant Human CD22, Fc-tagged
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Cat.#:CD22-562HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human CD22 protein, Fc-tagged
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Cat.#:CD22-179MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Cd22, Fc tagged
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Cat.#:Cd22-535MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Cd22, His-tagged
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Cat.#:Cd22-1153RTag:Fc
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat Cd22 Protein, Fc-tagged
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Cat.#:Cd22-1154RTag:His
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat Cd22 Protein, His-tagged
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Cat.#:CD22-1212RTag:His
Source (Host):HEK293Species:Rhesus Macaque
Product nameRecombinant Rhesus CD22 Protein, His-tagged
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Cat.#:CD22-8854CTag:Fc
Source (Host):HEK293Species:Rhesus Macaque
Product nameRecombinant Rhesus CD22 protein, Fc-tagged
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Cat.#:CD22-5443ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish CD22
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Cat.#:CD22-960HTag:N/A
Source (Host):CHOSpecies:Human
Product nameRecombinant Human CD22 Molecule, Extracellular Domain
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Cat.#:CD22-1956HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human CD22 cell lysate
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Cat.#:CD22-001MCLTag:
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse CD22 cell lysate
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Involved Pathway

CD22 involved in several pathways and played different roles in them. We selected most pathways CD22 participated on our site, such as Cell adhesion molecules (CAMs), Hematopoietic cell lineage, B cell receptor signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CD22 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Cell adhesion molecules (CAMs)
ICOSLG; Ntng2; PDCD1; CNTN2; NCAM1A; CLDN20; ITGB8; F11R; CD99; ITGB1B.2
Hematopoietic cell lineage
CSF1; CD1C; IL4; FCGR1; IL3RA; CSF3R; CD1D; GP1BB; CD14; CD3E; CD3D
B cell receptor signaling pathway
MAPK1; PIK3R2; PIK3R3; KRAS; PIK3CA; GSK3B; RAC1; BLK; DOK3; NFATC3

Protein Function

CD22 has several biochemical functions, for example, carbohydrate binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CD22 itself. We selected most functions CD22 had, and list some proteins which have the same functions with CD22. You can find most of the proteins on our site.
Function
Related Protein
Function carbohydrate binding
Related Protein LGALS3; CD55; GALNT11; ILLR3; AIM1; LGALS13; ITLN1; MAN2B2; CD207; SIGLEC14
Function protein binding
Related Protein CDC14B; APEH; HYI; ANKRD10; ARL16; CDC25B; STK16; SUGP1; JUP; AP2M1

Interacting Protein

CD22 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CD22 here. Most of them are supplied by our site. Hope this information will be useful for your research of CD22.
SYK; LYN; PLCG1; PTPN6; PTPRC; cpxA; PIK3R1

CD22 Related Articles

Lv, W; Duan, QL; et al. Expression of B-cell-associated genes in peripheral blood mononuclear cells of patients with symptomatic pulmonary embolism. MOLECULAR MEDICINE REPORTS 11:2299-2305(2015).
Jabbour, E; O'Brien, S; et al. Prognostic factors for outcome in patients with refractory and relapsed acute lymphocytic leukemia treated with inotuzumab ozogamicin, a CD22 monoclonal antibody. AMERICAN JOURNAL OF HEMATOLOGY 90:193-196(2015).