dpp4
Share
  • Official Full Name
  • dipeptidyl-peptidase 4
  • Background
  • The protein encoded by this gene is identical to adenosine deaminase complexing protein-2, and to the T-cell activation antigen CD26. It is an intrinsic membrane glycoprotein and a serine exopeptidase that cleaves X-proline dipeptides from the N-terminus of polypeptides. [provided by RefSeq, Jul 2008]
  • Synonyms
  • DPP4; dipeptidyl-peptidase 4; CD26; ADABP; ADCP2; DPPIV; TP103; dipeptidyl peptidase 4; ADCP-2; DPP IV; dipeptidylpeptidase 4; dipeptidyl peptidase IV; T-cell activation antigen CD26; adenosine deaminase complexing protein 2; dipeptidylpeptidase IV (CD26, adenosine deaminase complexing protein 2);
Cat.#:DPP4-116HTag:His
Source (Host):Insect cellSpecies:Human
Product nameRecombinant Human DPP4 Protein, His-tagged
+Inquiry
Cat.#:DPP4-2540HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human DPP4 Protein, MYC/DDK-tagged
+Inquiry
Cat.#:DPP4-2844HTag:
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human DPP4 Protein
+Inquiry
Cat.#:DPP4-2845HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human DPP4 Protein, GST-tagged
+Inquiry
Cat.#:Dpp4-413MTag:His
Source (Host):NS0Species:Mouse
Product nameRecombinant Mouse Dipeptidylpeptidase 4, His-tagged
+Inquiry
Cat.#:DPP4-1081HTag:HIS
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human DPP4, His-tagged
+Inquiry
Cat.#:DPP4-134HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human DPP4
+Inquiry
Cat.#:DPP4-215HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human DPP4 protein, His-tagged
+Inquiry
Cat.#:DPP4-269HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human DPP4, Fc tagged
+Inquiry
Cat.#:DPP4-270HTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human DPP4, None tagged
+Inquiry
Cat.#:DPP4-27111THTag:His
Source (Host):High-5 insect cellsSpecies:Human
Product nameRecombinant Human DPP4, His-tagged
+Inquiry
Cat.#:DPP4-27255THTag:His
Source (Host):Species:Human
Product nameRecombinant Human DPP4, His-tagged
+Inquiry
Cat.#:DPP4-3739HTag:N/A
Source (Host):NativeSpecies:Human
Product nameHuman 1PFQ
+Inquiry
Cat.#:DPP4-4760HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human Dipeptidyl-Peptidase 4, His-tagged
+Inquiry
Cat.#:DPP4-7872HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human DPP4 protein, His-tagged
+Inquiry
Cat.#:DPP4-8313HTag:His
Source (Host):High-5 insect cellsSpecies:Human
Product nameRecombinant Human DPP4, His tagged
+Inquiry
Cat.#:Dpp4-120MTag:Fc
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Dpp4, Fc-tagged
+Inquiry
Cat.#:Dpp4-415MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Dpp4 protein, His-tagged
+Inquiry
Cat.#:DPP4-4794MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse DPP4 Protein
+Inquiry
Cat.#:Dpp4-7873MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Dpp4 protein, His-tagged
+Inquiry
Cat.#:Dpp4-7874MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Dpp4 protein, His-tagged
+Inquiry
Cat.#:DPP4-1943RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat DPP4 Protein
+Inquiry
Cat.#:Dpp4-7875RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Dpp4 protein, His-tagged
+Inquiry
Cat.#:DPP4-119CTag:Fc
Source (Host):HEK293Species:Cynomolgus Monkey
Product nameRecombinant Cynomolgus DPP4, Fc-tagged
+Inquiry
Cat.#:DPP4-1203CTag:His
Source (Host):HEK293Species:Cynomolgus Monkey
Product nameRecombinant Cynomolgus DPP4 Protein, His-tagged
+Inquiry
Cat.#:DPP4-201CTag:
Source (Host):HEK293Species:Cynomolgus Monkey
Product nameRecombinant Cynomolgus DPP4
+Inquiry
Cat.#:DPP4-95CTag:N/A
Source (Host):HEK293Species:Cynomolgus Monkey
Product nameRecombinant Cynomolgus DPP4, Fc tagged
+Inquiry
Cat.#:DPP4-1323RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey DPP4 Protein, His-tagged
+Inquiry
Cat.#:DPP4-2913CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken DPP4
+Inquiry
Cat.#:DPP4-7484ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish DPP4
+Inquiry
Cat.#:DPP4-752HTag:N/A
Source (Host):S. frugiperdaSpecies:Human
Product nameRecombinant Human Dipeptidyl-peptidase 4, His-tagged
+Inquiry
Cat.#:DPP4-197HTag:
Source (Host):Species:Human
Product nameNative Human Dipeptidyl Peptidase IV
+Inquiry
Cat.#:DPP4-31HTag:
Source (Host):Species:Human
Product nameNative Human DPP4
+Inquiry
Cat.#:DPP4-2979HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human DPP4 cell lysate
+Inquiry
Cat.#:DPP4-733CCLTag:
Source (Host):HEK293Species:Cynomolgus Monkey
Product nameRecombinant Cynomolgus DPP4 cell lysate
+Inquiry
Cat.#:Kit-0312Tag:
Source (Host):Species:
Product nameDipeptidyl peptidase IV Inhibitor Screening Assay Kit
+Inquiry
Cat.#:Kit-0313Tag:
Source (Host):Species:
Product nameDPP IV Immunocapture Activity Assay Kit
+Inquiry
Cat.#:Kit-0314Tag:
Source (Host):Species:
Product nameDPP4 Activity Fluorometric Assay Kit
+Inquiry
Cat.#:Kit-0315Tag:
Source (Host):Species:
Product nameDPP4 Inhibitor Screening Kit
+Inquiry
Cat.#:Kit-0317Tag:
Source (Host):Species:
Product nameDPPIV/CD26 Assay Kit
+Inquiry
Cat.#:Kit-0316Tag:
Source (Host):Species:
Product nameDPPIV drug discovery Kit
+Inquiry

Involved Pathway

DPP4 involved in several pathways and played different roles in them. We selected most pathways DPP4 participated on our site, such as Incretin synthesis, secretion, and inactivation, Metabolism of proteins, Peptide hormone metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with DPP4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Incretin synthesis, secretion, and inactivation
GRP; SPCS3; GPR120; DPP4; CDX2; PCSK1; O3far1; SLC38A8; GPR119
Metabolism of proteins
B3GNT6; FBXL5; GPR119; SEC22A; IGFBP5; PHC2; EEF1A1; ASNA1; GALNTL5; SFTPBB
Peptide hormone metabolism
SPCS3; SLC30A8; INHA; SLC30A6; GZMH; GPR120; RAB27A; CMA1; SLC30A5; CPN1
Protein digestion and absorption
ATP1A3; SLC8A1; PRSS1; PRCP; COL6A4; ATP1B2; KCNE3; ATP1B4; SLC8A2; SLC3A1
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)
SLC38A8; GPR119; O3far1; DPP4; PCSK1; SPCS3; CDX2
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
GPR119; PCSK1; DPP4

Protein Function

DPP4 has several biochemical functions, for example, dipeptidyl-peptidase activity, identical protein binding, protease binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DPP4 itself. We selected most functions DPP4 had, and list some proteins which have the same functions with DPP4. You can find most of the proteins on our site.
Function
Related Protein
Function dipeptidyl-peptidase activity
Related Protein PRCP; DPEP1; DPP4; DPP8; FAP; DPEP2; DPP3; DPEP3; DPP7; NAALAD2
Function identical protein binding
Related Protein CHMP4A; UBQLN4; HOOK2; NONO; FZD1; SNCA; PLDN; RAD52; KHDC1A; C1QL4
Function protease binding
Related Protein CCDC71L; A2M; ADAMTS4; ECM1; FN1; TNFRSF10A; ITGB1; BRCA2; SEMG2; ELANE
Function protein binding
Related Protein SPACA3; TINF2; ATPAF2; WFDC9; MAP6; NR2F6; HIST1H3A; ACKR4; HK2; EXOSC10
Function protein homodimerization activity
Related Protein CRTAM; TRIM37; IL6R; SLC9A7; Defa-rs7; PDCD6IP; IL17F; SMAD2; PRPS1; PLDN
Function receptor binding
Related Protein AMN; DPP4; AGRP2; CADM2; UCN2; Fgf15; AMH; GUSB; RASA1; ZAP70
Function serine-type endopeptidase activity
Related Protein GZMC; KLK8; DPP4; PRSS12; C1RA; PRSS58; KLK1B8; KLK15; TPP1; PRSS45
Function serine-type peptidase activity
Related Protein ENDOU; PRSS59.1; Prss32; OVCH2; F7; TPSAB1; PRSS40; KLK1B24; PLAUB; KLK1B3
Function virus receptor activity
Related Protein XPR1; CR2; CD209; SLC1A5; ITGB7; ITGB5; NPC1; ICAM1; CXADR; AXL

Interacting Protein

DPP4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DPP4 here. Most of them are supplied by our site. Hope this information will be useful for your research of DPP4.
CXCL11; CXCL10; CXCL2; CCL11; CXCL9

DPP4 Related Articles

Gierer, S; Muller, MA; et al. Inhibition of Proprotein Convertases Abrogates Processing of the Middle Eastern Respiratory Syndrome Coronavirus Spike Protein in Infected Cells but Does Not Reduce Viral Infectivity. JOURNAL OF INFECTIOUS DISEASES 211:889-897(2015).
Tiezzi, F; Parker-Gaddis, KL; et al. A Genome-Wide Association Study for Clinical Mastitis in First Parity US Holstein Cows Using Single-Step Approach and Genomic Matrix Re-Weighting Procedure. PLOS ONE 10:-(2015).