faslg
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  • Official Full Name
  • Fas ligand (TNF superfamily, member 6)
  • Background
  • The Fas receptor (FasR) is a death receptor on the surface of cells that leads to programmed cell death (apoptosis). It is one of two apoptosis pathways, the other being the mitochondrial pathway. FasR is also known as CD95, Apo-1, and tumor necrosis factor receptor superfamily, member 6 (TNFRSf6). FasR is located on chromosome 10 in humans and 19 in mice. Similar sequences related by evolution are found in most mammals. Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. May be involved in cytotoxic T-cell mediated apoptosis and in T-cell development. TNFRSF6/FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. Binding to the decoy receptor TNFRSF6B/DcR3 modulates its effects. The protein encoded by this gene is the ligand for FAS. Both are transmembrane proteins. Interaction of FAS with this ligand is critical in triggering apoptosis of some types of cells such as lymphocytes. Defects in this gene may be related to some cases of systemic lupus erythematosus (SLE).
  • Synonyms
  • FASLG; Fas ligand (TNF superfamily, member 6); FASL; CD178; CD95L; CD95-L; TNFSF6; APT1LG1; tumor necrosis factor ligand superfamily member 6; APTL; CD95 ligand; OTTHUMP00000032708; fas antigen ligand; apoptosis antigen ligand; apoptosis (APO-1) antigen ligand 1; tumor necrosis factor (ligand) superfamily, member 6; soluble form; APO1L; Apoptosis antigen ligand 1; CD178 antigen; CD95; L CD95L protein; Fas L; Fas ligand; Fasl Fas ligand (TNF superfamily member 6); Generalized lymphoproliferative disease; Gld; TNF superfamily member 6; TNFL6_HUMAN; Fas-L
Cat.#:FASLG-1394HTag:His
Source (Host):YeastSpecies:Human
Product nameRecombinant Human FASLG Protein (103-281 aa), His-tagged
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Cat.#:Faslg-372MTag:His
Source (Host):YeastSpecies:Mouse
Product nameRecombinant Mouse Faslg Protein, His-tagged
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Cat.#:Faslg-373RTag:His
Source (Host):YeastSpecies:Rat
Product nameRecombinant Rat Faslg Protein, His-tagged
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Cat.#:FASLG-3855HTag:N/A
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human FASLG Protein
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Cat.#:FASLG-3857HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human FASLG Protein, GST-tagged
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Cat.#:FASLG-5412HTag:His
Source (Host):CHO cellsSpecies:Human
Product nameRecombinant Human Fas Ligand (TNF superfamily, member 6), His-tagged
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Cat.#:FASLG-5413HTag:N/A
Source (Host):CHO cellsSpecies:Human
Product nameRecombinant Human Fas Ligand (TNF superfamily, member 6)
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Cat.#:FASLG-151HTag:Fc
Source (Host):YeastSpecies:Human
Product nameRecombinant Human FASLG, His tagged
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Cat.#:FASLG-234HTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human FASLG, C13&N15-labeled
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Cat.#:FASLG-245HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human FASLG, Fc-tagged
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Cat.#:FASLG-28165THTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human FASLG
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Cat.#:FASLG-46HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human FASLG protein, His-tagged
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Cat.#:FASLG-623HTag:His|GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human FASLG protein, His & GST-tagged
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Cat.#:FASLG-624HTag:His|S
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human FASLG protein, His & S-tagged
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Cat.#:FASLG-7108HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human FASLG, His-tagged
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Cat.#:FASLG-2274RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat FASLG Protein
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Cat.#:Faslg-626RTag:His|GST
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Faslg protein, His & GST-tagged
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Cat.#:FASLG-514CTag:His
Source (Host):Mammalian CellsSpecies:Cynomolgus Monkey
Product nameRecombinant Cynomolgus FASLG Protein, His-tagged
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Cat.#:FASLG-1645RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey FASLG Protein, His-tagged
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Cat.#:FASLG-627RTag:His|T7
Source (Host):E. coliSpecies:Rhesus monkey
Product nameRecombinant Rhesus monkey FASLG protein, His & T7-tagged
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Cat.#:FASLG-3201CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken FASLG
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Cat.#:FASLG-3825ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish FASLG
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Cat.#:FASLG-1616HTag:N/A
Source (Host):NS0Species:Human
Product nameRecombinant Human Fas ligand (TNF superfamily, member 6)
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Cat.#:Fasl-1736MTag:N/A
Source (Host):NS0Species:Mouse
Product nameRecombinant Mouse Fas Ligand (TNF Superfamily, Member 6)
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Cat.#:FASLG-2424HTag:Flag
Source (Host):HEK293Species:Human
Product nameRecombinant Human FASLG, FLAG-tagged
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Cat.#:FASLG-2703HTag:His
Source (Host):CHOSpecies:Human
Product nameRecombinant Human FASLG, His-tagged
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Cat.#:FASLG-6324HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human FASLG 293 Cell Lysate
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Involved Pathway

FASLG involved in several pathways and played different roles in them. We selected most pathways FASLG participated on our site, such as MAPK signaling pathway, Ras signaling pathway, Cytokine-cytokine receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with FASLG were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
MAPK signaling pathway
ARRB1; FGF8A; CACNA2D2; FGF6A; MYCB; CACNA2D4; MAP2K2; TGFBR1A; SRF; CACNG1
Ras signaling pathway
MET; PDGFC; RASSF5; FGF12; RASGRF2; GNGT2; NGFR; VEGFA; NGF; REL
Cytokine-cytokine receptor interaction
BMP7; IL28A; NGFRB; IFNW1; IL2RGB; TGFB1A; EPO; IFNGR2; ACVR2B; Flt3l
FoxO signaling pathway
PIK3R2; CDKN2B; PLK2B; PIK3R3A; FOXO1; PRKAG1; EGFRA; BCL6; HOMER2; GABARAPL2
PIK-Akt signaling pathway
HSP90AA1; LAMB4; GNG3; BAD; PIK3R5; IFNA16; NGF; ANGPT1; PDPK1; IL4R
Apoptosis
BCL2L11; AKT1; PIK3CD; AKT2L; BOK; HRK; DIABLO; IL1B2; BIRC5A; TNFRSFA
Natural killer cell mediated cytotoxicity
NCR1; KIR2DS3; RAET1D; ITGB2; HLA-C; HCST; CD48; TNFRSF10D; PAK1; KLRC2
Neurotrophin signaling pathway
FASLG; BCL2; MAP2K5; Fasl; PSEN1; NTRK1; TP73; NRAS; IKBKB; IRS1
Non-alcoholic fatty liver disease (NAFLD)
FASLG; SREBF1; CASP8; COX6A2; NDUFB4; NDUFA1; NDUFS7; IL6; COX7A2; NDUFB1
Type I diabetes mellitus
INS2; IFNG; GAD1; HLA-DQA2; HLA-DMB; HSPD1; H2-AB1; IL12A; LTA; HLA-DRB5
Chagas disease (American trypanosomiasis)
MAPK3; IL-8; NFKB1; Ccl12; PPP2R1A; LOC100033925; TLR4; CCL2; CCL5; PPP2R2B
African trypanosomiasis
ICAM1; IL18; HBB; IL12A; IFNG; GNAQ; APOL1; PLCB3; VCAM1; PLCB1
Hepatitis B
TGFBR1; CCND1; BAX; IFNA13; TBK1; MAP3K1; PRKCA; EP300; ATP6AP1; MAPK10
Measles
NFKB1; AKT1; IL2RA; MAVS; TLR2; TYK2; IL2RB; IFNA14; IFNA1; PIK3CA
Influenza A
IRAK4; Ccl12; IL8L2; TLR7; GSK3B; DDX39B; PIK3R5; HSPA1B; PRSS3; MAPK13
Herpes simplex infection
TAP2; TAF6L; USP7; EIF2AK2; IFNA21; Casp3; ARNTL1A; IRF3; PER3; MHC1UXA2
Pathways in cancer
BDKRB1; Fzd4; ITGA2B; RELA; HSP90AA1; IL6; LAMB2; CCNE1; PGF; GNGT2
Proteoglycans in cancer
PIK3R1; ANK1; ERBB4; RPS6KB2; ITGB1; TP53; FLNC; TWIST1; PIK3CB; PPP1CB
Autoi
IL5; IFNA12; Il2; IFNA13; HLA-G; HLA-DOB; IFNA2; HLA-DOA; HLA-E; HLA-DMB
ne thyroid disease
IFNA13; HLA-DRB1; Ifna11; CD86; H2-AB1; HLA-DOB; HLA-DQA1; HLA-DQB1; IFNA1; IL4
Allograft rejection
H2-AB1; HLA-DRB4; HLA-DOA; HLA-DRB5; IL5; HLA-A; IL12B; HLA-DMB; HLA-E; HLA-DPA1
Graft-versus-host disease
KLRD1; IL1A; KIR2DL3; HLA-DOA; HLA-DRB4; PRF1; HLA-DPA1; HLA-G; FASLG; H2-AB1

Protein Function

FASLG has several biochemical functions, for example, cytokine activity, death receptor binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FASLG itself. We selected most functions FASLG had, and list some proteins which have the same functions with FASLG. You can find most of the proteins on our site.
Function
Related Protein
Function cytokine activity
Related Protein LIF; IFNA7; CMTM7; OSTN; PRL7D1; IFNB; INHBB; BMP10; INHA; GPR19
Function death receptor binding
Related Protein NOL3; TMBIM1; CFLAR; FASLG; BID; MYD88; FEM1B; PRDM4; FADD; PIDD1
Function protein binding
Related Protein NKAP; MIA3; SPINK2; VPS18; ZBTB6; IFT20; TRAF2; RAB8B; CACNB4; DDX58
Function receptor binding
Related Protein NXPH3; GCG; GNPAT; ADAM10; ARRB2; LBP; MATK; WNT11R; FGF24; DIAPH1
Function tumor necrosis factor receptor binding
Related Protein TNFSF11; TRAF1; TNFSF8; Fasl; TNFSF10L; FADD; TRAF2; BRE; TNFSF10L4; TRAF4

Interacting Protein

FASLG has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FASLG here. Most of them are supplied by our site. Hope this information will be useful for your research of FASLG.
PSTPIP1; FAS; FADD; CASP8; SRGAP2; FYN

FASLG Related Articles

Senapati, S; Gutierrez-Achury, J; et al. Evaluation of European coeliac disease risk variants in a north Indian population. EUROPEAN JOURNAL OF HUMAN GENETICS 23:530-535(2015).
Barathan, M; Gopal, K; et al. Chronic hepatitis C virus infection triggers spontaneous differential expression of biosignatures associated with T cell exhaustion and apoptosis signaling in peripheral blood mononucleocytes. APOPTOSIS 20:466-480(2015).

FASLG Related Gene Family

TNF