il6r
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  • Official Full Name
  • interleukin 6 receptor
  • Background
  • his gene encodes a subunit of the interleukin 6 (IL6) receptor complex. Interleukin 6 is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in the immune response. The IL6 receptor is a protein complex consisting of this protein and interleukin 6 signal transducer (IL6ST/GP130/IL6-beta), a receptor subunit also shared by many other cytokines. Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer. Alternatively spliced transcript variants encoding distinct isoforms have been reported. A pseudogene of this gene is found on chromosome 9.
  • Synonyms
  • IL6Q; gp80; CD126; IL6RA; IL6RQ; IL-6RA; IL-6R-1; interleukin 6 receptor; IL6R
Cat.#:IL6R-584HTag:
Source (Host):HEK293 cellsSpecies:Human
Product nameRecombinant Human IL6R Protein
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Cat.#:IL6R-1058HTag:
Source (Host):E.coliSpecies:Human
Product nameRecombinant Human IL-6 Protein
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Cat.#:IL6R-457RTag:His
Source (Host):HEK293Species:Rhesus
Product nameRecombinant Rhesus IL6R Protein, His-tagged
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Cat.#:IL6R-787HTag:His-Avi
Source (Host):HEK293Species:Human
Product nameRecombinant Human IL6R Protein, His-Avi-tagged, Biotinylated
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Cat.#:IL6R-2176HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human IL6R Protein, MYC/DDK-tagged
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Cat.#:IL6R-5174HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human IL6R Protein, GST-tagged
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Cat.#:IL6R-5175HTag:
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human IL6R Protein
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Cat.#:IL6R-056RTag:Fc
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat IL6R Protein, Fc-tagged
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Cat.#:IL6R-100HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Interleukin-6 Soluble Receptor,His-tagged
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Cat.#:IL6R-200HTag:Fc
Source (Host):CHOSpecies:Human
Product nameRecombinant Human IL6R, MIgG2a Fc-tagged
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Cat.#:IL6R-201HTag:Fc
Source (Host):CHOSpecies:Human
Product nameRecombinant Human IL6R, HIgG1 Fc-tagged
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Cat.#:IL6R-239HTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human IL6R, C13&N15-labeled
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Cat.#:IL6R-29271THTag:
Source (Host):Species:Human
Product nameRecombinant Human IL6R
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Cat.#:IL6R-322HTag:Fc
Source (Host):CHOSpecies:Human
Product nameRecombinant Human IL6R, Fc-tagged
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Cat.#:IL6R-428HTag:His
Source (Host):NSO cellsSpecies:Human
Product nameRecombinant Human IL6R, His-tagged
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Cat.#:IL6R-786HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human IL6R, His tagged
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Cat.#:IL6R-964HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Interleukin 6 Receptor
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Cat.#:Il6r-1145RTag:His
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat Il6r Protein, His-tagged
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Cat.#:Il6r-1836RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Il6r protein, His-tagged
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Cat.#:Il6r-9168HTag:His
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat Il6r, His-tagged
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Cat.#:Il6r-935RTag:His
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat Il6r, His-tagged
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Cat.#:IL6R-1559RTag:
Source (Host):HEK293Species:Rhesus monkey
Product nameRecombinant Rhesus Monkey IL6R Protein
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Cat.#:IL6R-1560RTag:hIgG1
Source (Host):HEK293Species:Rhesus monkey
Product nameRecombinant Rhesus Monkey IL6R Protein, hIgG1-tagged
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Cat.#:IL6R-1561RTag:hIgG4
Source (Host):HEK293Species:Rhesus monkey
Product nameRecombinant Rhesus Monkey IL6R Protein, hIgG4-tagged
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Cat.#:IL6R-1064CTag:His
Source (Host):HEK293Species:Canine
Product nameRecombinant Canine IL6R Protein, His-tagged
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Cat.#:IL6R-6383ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish IL6R
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Cat.#:IL6R-9166HTag:His
Source (Host):HEK293Species:Macaca mulatta
Product nameRecombinant Cynomolgus IL6R, His-tagged
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Cat.#:IL6R-545HTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human Interleukin 6 Receptor
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Cat.#:IL6R-1241HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Interleukin 6 Receptor, His-tagged
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Cat.#:IL6R-1242HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Interleukin 6 Receptor
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Cat.#:IL6R-2903HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human IL6R cell lysate
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Involved Pathway

IL6R involved in several pathways and played different roles in them. We selected most pathways IL6R participated on our site, such as Cytokine-cytokine receptor interaction, HIF- signaling pathway, PIK-Akt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IL6R were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Cytokine-cytokine receptor interaction
CCR1; TNFRSF19; ACVR2B; LEPA; IL8L2; KITLGA; PRP2; BMPR2B; PRLR; CXCL8B.3
HIF- signaling pathway
PRKCA; PRKCB; RBX1; TEK; MKNK2; IGF1R; MAPK1; IFNGR1; IGF1; TCEB1
PIK-Akt signaling pathway
TCL1B1; TCL1B4; PDGFRB; PIK3R5; THBS2; PPP2R1A; PPP2R2B; GNB2; IFNA21; ITGB5
Jak-STAT signaling pathway
FHL1A; IFNE; IL29; NT5C3; PTPN11A; SOCS3; IL11; LIF; IFNPHI1; IRX1
Hematopoietic cell lineage
CD24; GP9; CD1E; CD3E; CD3D; CD1D; IL11RA2; HLA-DRB5; Il6ra; CD1C
Non-alcoholic fatty liver disease (NAFLD)
NDUFB8; PRKAB2; UQCRC1; NDUFA13; FAS; NDUFS6; NDUFA7; COX8C; NDUFS2; ADIPOR1

Protein Function

IL6R has several biochemical functions, for example, ciliary neurotrophic factor binding, contributes_to ciliary neurotrophic factor receptor activity, enzyme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IL6R itself. We selected most functions IL6R had, and list some proteins which have the same functions with IL6R. You can find most of the proteins on our site.
Function
Related Protein
Function ciliary neurotrophic factor binding
Related Protein IL6R; Il6ra
Function contributes_to ciliary neurotrophic factor receptor activity
Related Protein IL6R; Il6ra; LIFR; CNTFR
Function enzyme binding
Related Protein HIST1H2AE; PPP3CB; NOTCH3; CALU; APBA3; CYP3A4; CD40; ATG3; BLZF1; LAMP2
Function interleukin-6 binding
Related Protein IL6R; Il6ra
Function contributes_to interleukin-6 receptor activity
Related Protein IL6ST; IL6R; Il6ra
Function contributes_to interleukin-6 receptor binding
Related Protein IL6ST; IL6R; IL6; Il6ra
Function protein binding
Related Protein SLC9A3R2; AGPAT4; PPP1R15A; TNFRSF21; NR2F6; COPS7A; CUL1; NPEPL1; GAB3; FAM71C
Function protein homodimerization activity
Related Protein DPY30; TLR13; ERCC5; HNF4A; PRPS1L1; SPATA24; RAG1; Flt3l; TGFB2; MAPK4

Interacting Protein

IL6R has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL6R here. Most of them are supplied by our site. Hope this information will be useful for your research of IL6R.
IL6; K2; JAK1; ERAP1; Adam17; IL6ST

IL6R Related Articles

Tseng-Rogenski, SS; Hamaya, Y; et al. Interleukin 6 Alters Localization of hMSH3, Leading to DNA Mismatch Repair Defects in Colorectal Cancer Cells. GASTROENTEROLOGY 148:579-589(2015).
Kim, G; Ouzounova, M; et al. SOCS3-mediated regulation of inflammatory cytokines in PTEN and p53 inactivated triple negative breast cancer model. ONCOGENE 34:671-680(2015).

IL6R Related Gene Family

IL