MMP13
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Official Full Name
matrix metallopeptidase 13 (collagenase 3)
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Overview
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The protein encoded by this gene cleaves type II collagen more efficiently than types I and III. It may be involved in articular cartilage turnover and cartilage pathophysiology associated with osteoarthritis. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. [provided by RefSeq, Jul 2008] -
Synonyms
MMP13; matrix metallopeptidase 13 (collagenase 3); CLG3; MANDP1; MMP-13; collagenase 3; matrix metalloproteinase 13 (collagenase 3);
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Cattle
- Chicken
- Dog
- Human
- Mouse
- Pig
- Rabbit
- Rat
- E. coli
- E.coli
- HEK293
- HEK293F
- In Vitro Cell Free System
- Mammalian Cell
- Mammalian cells
- Sf9 Insect Cell
- Spodoptera Frugiperda
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- His(C
- ter)
- His|SUMO
- His|T7
- SUMO
- N/A
- N
- No tag
- T7|His
- Involved Pathway
- Protein Function
- Interacting Protein
- MMP13 Related Articles
- MMP13 Related Gene Family
- MMP13 Related Research Area
MMP13 involved in several pathways and played different roles in them. We selected most pathways MMP13 participated on our site, such as AGE/RAGE pathway, Activation of Matrix Metalloproteinases, Assembly of collagen fibrils and other multimeric structures, which may be useful for your reference. Also, other proteins which involved in the same pathway with MMP13 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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AGE/RAGE pathway | JUN;MMP13;EGFR;TIRAP;MAPK14;CHUK;LGALS3;JAK2;ATF2 |
Activation of Matrix Metalloproteinases | TIMP2B;MMP17;MMP10;MMP13;CTSLL;CTSG;MMP11;CTRB1;CTSL2 |
Assembly of collagen fibrils and other multimeric structures | COL8A1A;COL5A3B;COL10A1;COL4A5;TLL2;COL1A2;DST;COL3A1;COL5A2 |
Collagen degradation | CTSD;COL19A1;COL13A1;ELANE;ADAM10;LOC100686744;CTSLL;MMP19;CTS7 |
Collagen formation | COL11A1B;COL8A2;COL5A1;CRTAP;BMP1A;COL19A1;MMP13;PCOLCEB;COL15A1B |
Degradation of the extracellular matrix | TIMP2A;COL9A3;TLL1;ELANE;FURINA;TLL2;CAPNS1;COL15A1B;COL9A1 |
Endochondral Ossification | PTH;COL2A1;RUNX3;CDKN1C;CST5;MGP;IFT88;SERPINH1;DDR2 |
Extracellular matrix organization | COL9A1B;SPARC;LOXL4;MMP20;SERPINH1;COMP;JAM2B;FURINA;ADAM15 |
MMP13 has several biochemical functions, for example, calcium ion binding, calcium-dependent protein binding, collagen binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MMP13 itself. We selected most functions MMP13 had, and list some proteins which have the same functions with MMP13. You can find most of the proteins on our site.
Function | Related Protein |
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calcium ion binding | MYLPFB;CAPN2A;DSG2;SPOCK2;TESCB;TBC1D9B;MYL9B;PCDH2G28;THBS2 |
calcium-dependent protein binding | CLEC4M;CCDC167;MBL2;MYO5A;TNNT3;STX2;KCNIP3;SELP;S100A11 |
collagen binding | SERPINH2;PAK1;DDR2;CTSL1;TGFBI;PCOLCE;LUM;CTSS;ABI3BP |
fibronectin binding | CTSL1;SDC4;FSTL3;ITGAV;ITGB3;IGFBP5B;IGFBP5A;ITGB1;MMP13 |
low-density lipoprotein particle receptor binding | LRPAP1;SYT1;SLC9A3R2;SNX17;APOA5;APOE;ARRB2;APOB;MESDC2 |
metalloendopeptidase activity | SPG7;UQCRC2;NPSN;HE2;MEP1A.1;KEL;MMP7;PAPLN;MMP15 |
zinc ion binding | ADAM33;ZMYM2;NR6A1A;ADAM5P;ZFPL1;BRF1;ANPEPB;CA4A;ING3 |
MMP13 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MMP13 here. Most of them are supplied by our site. Hope this information will be useful for your research of MMP13.
- Q&As
- Reviews
Q&As (5)
Ask a questionYes, targeting MMP13 has been explored as a potential therapeutic strategy to inhibit cancer metastasis and invasion.
Yes, MMP13 has been implicated in cardiovascular diseases by contributing to the remodeling of blood vessels and cardiac tissues.
MMP13 facilitates tumor invasion and metastasis by breaking down the extracellular matrix and promoting the migration of cancer cells.
Certain genetic variations in the MMP13 gene have been linked to increased susceptibility to diseases such as osteoarthritis and cancer.
Some clinical trials are investigating drugs that specifically target MMP13 in various cancer types to assess their efficacy and safety.
Customer Reviews (3)
Write a reviewIts reliability and versatility make it an essential tool for investigating MMP13 protein's expression, function, and structural characteristics.
The use of MMP13 protein in this technique allows researchers to explore the intricate three-dimensional structure of the protein at a molecular level.
MMP13 protein is highly recommended for researchers due to its excellent performance in WB experiments and its utility in protein electron microscopy structure analysis.
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