MMP13 Protein, matrix metallopeptidase 13 (collagenase 3)

MMP13

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MMP13

Official Full Name matrix metallopeptidase 13 (collagenase 3)
Background Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The protein encoded by this gene cleaves type II collagen more efficiently than types I and III. It may be involved in articular cartilage turnover and cartilage pathophysiology associated with osteoarthritis. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. [provided by RefSeq, Jul 2008]
Synonyms MMP13; matrix metallopeptidase 13 (collagenase 3); CLG3; MANDP1; MMP-13; collagenase 3; matrix metalloproteinase 13 (collagenase 3);
    • Species :
    • Chicken
    • Dog
    • Human
    • Mouse
    • Pig
    • Rabbit
    • Rat
    • Source :
    • E.coli
    • HEK293
    • HEK293F
    • Mammalian Cell
    • NSO
    • Sf9 Insect Cell
    • Spodoptera Frugiperda
    • Wheat Germ
    • Tag :
    • GST
    • His
    • SUMO
    • T7
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Dog MMP13-2045D Recombinant Dog MMP13 Protein (28-478 aa), His-SUMO-tagged E.coli His/SUMO
    Human MMP13-1018H Recombinant Human MMP13 E.coli N/A
    Human MMP13-159H Recombinant Human MMP13 protein E.coli N/A
    Human MMP13-27H Recombinant Human MMP13 protein E.coli N/A
    Human MMP13-411H Recombinant Human Matrix Metallopeptidase 13 (collagenase 3) NSO N/A
    Human MMP13-4280HCL Recombinant Human MMP13 293 Cell Lysate HEK293 N/A
    Human MMP13-42H Recombinant Human MMP-13 Spodoptera Frugiperda N/A
    Human MMP13-43H Recombinant Human MMP-13, activated Spodoptera Frugiperda N/A
    Human MMP13-443H Recombinant Human matrix metallopeptidase 13 (collagenase 3), His-tagged E.coli His
    Human MMP13-5044H Recombinant Human MMP13, His-tagged E.coli His
    Human MMP13-5420H Recombinant Human MMP13 Protein E.coli N/A
    Human MMP13-5421H Recombinant Human MMP13 Protein, GST-tagged Wheat Germ GST
    Human MMP13-729H Recombinant Human MMP13 protein, His-tagged E.coli His
    Human MMP13-810H Recombinant Human MMP13, His-tagged Sf9 Insect Cell His
    Human MMP13-92H Recombinant Human MMP13 protein, T7/His-tagged E.coli T7/His
    Mouse Mmp13-1750M Recombinant Mouse Mmp13 protein, His-tagged E.coli His
    Mouse Mmp13-731M Recombinant Mouse Mmp13 protein, His-tagged E.coli His
    Mouse MMP13-9908M Recombinant Mouse MMP13 Protein Mammalian Cell His
    Rat Mmp13-506R Recombinant Rat Mmp13 protein, His-tagged HEK293F His
    Rat Mmp13-734R Recombinant Rat Mmp13 protein, His-tagged E.coli His
    Chicken MMP13-5521C Recombinant Chicken MMP13 Mammalian Cell His
    Rabbit MMP13-736R Recombinant Rabbit MMP13 protein, His-tagged E.coli His
    Pig MMP13-733P Recombinant Pig MMP13 protein, His & T7-tagged E.coli His/T7

    MMP13 involved in several pathways and played different roles in them. We selected most pathways MMP13 participated on our site, such as AGE/RAGE pathway, Activation of Matrix Metalloproteinases, Assembly of collagen fibrils and other multimeric structures, which may be useful for your reference. Also, other proteins which involved in the same pathway with MMP13 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    AGE/RAGE pathway CHUK; JAK2; LGALS3; MAPK14; DIAPH1; EGFR; ATF2; AGER; DDOST; TIRAP
    Activation of Matrix Metalloproteinases CTSLL; TIMP2A; FURINA; FURINB; MMP8; CTSL2; MGC174155; MMP11; LOC100686744; CTSK
    Assembly of collagen fibrils and other multimeric structures COL8A1; COL5A2; PCOLCE; BMP1B; COL5A1; COL5A3B; CTSB; LOXL4; COL10A1A; COL5A3A
    Collagen degradation ELANE; COL19A1; MMP19; ADAM10; CTSL1; MMP10; MMP8; COL13A1; COL9A3; COL17A1
    Collagen formation CTSS; PPIB; LOXL3; COL23A1; COL6A1; LOXL4; ADAMTS3; MMP13; COL8A1A; COL17A1A
    Degradation of the extracellular matrix CTSD; MGC174857; MMP19; ADAM8; MGC174152; ADAM9; MMP8; BMP1B; CTRB1; COL19A1
    Endochondral Ossification SERPINH1; PTH; PTHLH; MGP; CST5; NKX3-2; SOX5; COL10A1A; SOX9A; CTSL2
    Extracellular matrix organization MGC174857; LAMB1B; MMP11; TLL1; TLDC2; MMP24; COL8A1; COL6A2; CTSLL; COL28A1A

    MMP13 has several biochemical functions, for example, calcium ion binding, calcium-dependent protein binding, collagen binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MMP13 itself. We selected most functions MMP13 had, and list some proteins which have the same functions with MMP13. You can find most of the proteins on our site.

    Function Related Protein
    calcium ion binding SLC25A13; CANT1B; RASGRP1; CETN3; KCNIP1; PCDH10; FSTL5; RASGRP3; PCDH1G11; aLA
    calcium-dependent protein binding KOP; MASP2; CD209A; DMBT1; RBM22; C9orf9; CHP1; S100PBP; PLSCR3; MBL1
    collagen binding VWF; ADAM9; SERPINH2; CD44; MMP9; Itga10&Itgb1; RELL2; SMAD3; CTSL1; LRRC15
    fibronectin binding FSTL3; LRRC15; LACRT; IGFBP5; MFAP2; ITGA3; VEGFA; ITGB1; SDC4; ITGAV
    low-density lipoprotein particle receptor binding LRPAP1; SNX17; AP2M1; MESDC2; CCDC167; DNAJA1; HSP90B1; SACS; LANCL1; ARRB2
    metalloendopeptidase activity PAPPA; OMA1; MMP14A; MMP23B; MBTPS2; ADAMTSL4; MMEL1; ADAMTS9; ZMPSTE24; ADAM15
    zinc ion binding TRAF7; GRIN2A; DNAJC24; KMT2A; RC3H1; PRKCBP1L; MBTD1; CHD4; NR6A1A; PDLIM3A

    MMP13 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MMP13 here. Most of them are supplied by our site. Hope this information will be useful for your research of MMP13.

    Ma, J; Zhou, D; et al. Keratocytes Create Stromal Spaces to Promote Corneal Neovascularization Via MMP13 Expression. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE 55:-(2014).
    Jackson, MT; Moradi, B; et al. Activation of Matrix Metalloproteinases 2, 9, and 13 by Activated Protein C in Human Osteoarthritic Cartilage Chondrocytes. ARTHRITIS & RHEUMATOLOGY 66:1525-1536(2014).

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