prnp
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  • Official Full Name
  • prion protein
  • Background
  • The protein encoded by this gene is a membrane glycosylphosphatidylinositol-anchored glycoprotein that tends to aggregate into rod-like structures. The encoded protein contains a highly unstable region of five tandem octapeptide repeats. This gene is found on chromosome 20, approximately 20 kbp upstream of a gene which encodes a biochemically and structurally similar protein to the one encoded by this gene. Mutations in the repeat region as well as elsewhere in this gene have been associated with Creutzfeldt-Jakob disease, fatal familial insomnia, Gerstmann-Straussler disease, Huntington disease-like 1, and kuru. Alternative splicing results in multiple transcript variants encoding the same protein.
  • Synonyms
  • PRNP; CJD; GSS; PrP; ASCR; PRIP; PrPc; CD230; prion; MGC26679; PrP27-30; PrP33-35C; prion protein; major prion protein; p27-30; CD230 antigen; prion protein PrP; OTTHUMP00000030161; OTTHUMP00000030162; OTTHUMP00000030163; OTTHUMP00000161139; prion-related protein; prion protein (p27-30) (Creutzfeldt-Jakob disease, Gerstmann-Strausler-Scheinker syndrome, fatal familial insomnia)
Cat.#:PRNP-742RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat PRNP Protein (29-231 aa), His-tagged
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Cat.#:PRNP-1898HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Prion Protein, His-tagged
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Cat.#:Prnp-1064MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Prion Protein, Globular Domain, His-tagged
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Cat.#:Prnp-1065MTag:N/A
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Prion Protein
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Cat.#:PRNP-373HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human PRNP, Fc-tagged
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Cat.#:PRNP-388HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PRNP Protein
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Cat.#:PRNP-7569HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PRNP, His-tagged
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Cat.#:PRNP-789HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Prion Protein, His-tagged
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Cat.#:PRNP-13424MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse PRNP Protein
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Cat.#:Prnp-289MTag:N/A
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Prnp Protein
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Cat.#:Prnp-791MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Prion Protein, His-tagged
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Cat.#:PRNP-4708RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat PRNP Protein
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Cat.#:PRNP-812CTag:His
Source (Host):Mammalian CellsSpecies:Cynomolgus Monkey
Product nameRecombinant Cynomolgus PRNP Protein, His-tagged
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Cat.#:PRNP-1616RTag:N/A
Source (Host):HEK293Species:Rhesus monkey
Product nameRecombinant Rhesus Monkey PRNP Protein
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Cat.#:PRNP-1617RTag:hIgG1
Source (Host):HEK293Species:Rhesus monkey
Product nameRecombinant Rhesus Monkey PRNP Protein, hIgG1-tagged
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Cat.#:PRNP-1618RTag:hIgG4
Source (Host):HEK293Species:Rhesus monkey
Product nameRecombinant Rhesus Monkey PRNP Protein, hIgG4-tagged
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Cat.#:PRNP-3617RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey PRNP Protein, His-tagged
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Cat.#:PRNP-290BTag:N/A
Source (Host):E. coliSpecies:Bovine
Product nameRecombinant Bovine PRNP Protein
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Cat.#:Prnp-799BTag:His
Source (Host):E. coliSpecies:Bovine
Product nameRecombinant Bovine Prion Protein, His-tagged
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Cat.#:Prnp-800BTag:His
Source (Host):E. coliSpecies:Bovine
Product nameRecombinant Bovine Prion Protein (T194A), His-tagged
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Cat.#:Prnp-801BTag:His
Source (Host):E. coliSpecies:Bovine
Product nameRecombinant Bovine Prion Protein (F209S), His-tagged
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Cat.#:Prnp-802BTag:His
Source (Host):E. coliSpecies:Bovine
Product nameRecombinant Bovine Prion Protein (Q228R), His-tagged
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Cat.#:Prnp-803BTag:His
Source (Host):E. coliSpecies:Bovine
Product nameRecombinant Bovine Prion Protein (A144V), His-tagged
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Cat.#:PRNP-7014CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken PRNP
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Cat.#:Prnp-191HTag:N/A
Source (Host):E. coliSpecies:Hamster
Product nameRecombinant Hamster Prnp Protein
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Cat.#:PRNP-652STag:His
Source (Host):E. coliSpecies:Sheep
Product nameRecombinant Sheep PRNP Protein, His-tagged
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Cat.#:Prnp-653HTag:His
Source (Host):E. coliSpecies:Hamster
Product nameRecombinant Hamster Prnp Protein, His-tagged
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Cat.#:Prnp-654HTag:His
Source (Host):E. coliSpecies:Hamster
Product nameRecombinant Hamster Prnp Protein, His-tagged
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Cat.#:Prnp-794HTag:His
Source (Host):E. coliSpecies:Hamster
Product nameRecombinant Hamster Prion Protein, His-tagged
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Cat.#:Prnp-797OTag:His
Source (Host):E. coliSpecies:Ovine
Product nameRecombinant Ovine Prion Protein, His-tagged
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Cat.#:PRNP-001HCLTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human PRNP cell lysate
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Involved Pathway

Prnp involved in several pathways and played different roles in them. We selected most pathways Prnp participated on our site, such as Prion diseases, which may be useful for your reference. Also, other proteins which involved in the same pathway with Prnp were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Prion diseases
ELK1; NCAM1; CASP12; C8B; SOD1; MAPK1; C1QA; HSPA5; LAMC1; C1QC

Protein Function

Prnp has several biochemical functions, for example, ATP-dependent protein binding, chaperone binding, copper ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Prnp itself. We selected most functions Prnp had, and list some proteins which have the same functions with Prnp. You can find most of the proteins on our site.
Function
Related Protein
Function ATP-dependent protein binding
Related Protein MYO5A; PRNP; DDX39B; SAE1; DNAJC5; STX1A
Function chaperone binding
Related Protein TBCE; AHSA1L; PACRG; SLC25A17; PARK2; ST13; TIMM10; AMFR; BAX; ERP29
Function copper ion binding
Related Protein COX17; CP; IL1A; MT1; S100A12; S100V2; PRND; MOXD1L; F8; S100A13
Function identical protein binding
Related Protein ESR1; NUFIP1; HACL1; PRKD1; SEPHS1; S100A2; PYDC3; CLDN7; ASMT; CEP170L
Function ion channel binding
Related Protein FXYD1; YWHAE; PKP2; PHPT1; HOMER1; PPP1R9B; TRPC1; ACTN1; KCNB1; SLC14A2
Function microtubule binding
Related Protein CETN2; GAPDH; CCDC87; CEP57; NEFH; DPYSL2B; RCC2; KIF3B; GABARAPA; NDE1
Function protein binding
Related Protein VAMP3; TLE3A; MRPS16; YES1; SLC25A5; MIEF1; PTBP3; TUBB2B; POGZ; RGS6
Function tubulin binding
Related Protein MTAP7D3; PRNP; TPR; AGTPBP1; TPPP3; STMN3; TPPP; STMN2; STMN2B; TBCA

Interacting Protein

Prnp has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Prnp here. Most of them are supplied by our site. Hope this information will be useful for your research of Prnp.
APP

Prnp Related Articles

Didonna, A; Venturini, AC; et al. Characterization of four new monoclonal antibodies against the distal N-terminal region of PrPC. PEERJ 3:-(2015).
Salazar, E; Berriatua, E; et al. Lack of relationship between Visna/maedi infection and scrapie resistance genetic markers. SPANISH JOURNAL OF AGRICULTURAL RESEARCH 12:676-682(2014).