RSPO1 Protein, R-spondin 1

RSPO1

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RSPO1

Official Full Name R-spondin 1
Background This gene encodes a secreted activator protein with two cysteine-rich, furin-like domains and one thrombospondin type 1 domain. The encoded protein is a ligand for leucine-rich repeat-containing G-protein coupled receptors (LGR proteins) and positively regulates the Wnt signaling pathway. In mice, the protein induces the rapid onset of crypt cell proliferation and increases intestinal epithelial healing, providing a protective effect against chemotherapy-induced adverse effects. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]
Synonyms RSPO1; R-spondin 1; RSPO; CRISTIN3; R-spondin-1; R-spondin homolog; roof plate-specific spondin-1;
    • Species :
    • Human
    • Mouse
    • Rat
    • Zebrafish
    • Source :
    • CHO
    • E.coli
    • HEK293
    • Human Cell
    • Mammalian Cell
    • Tag :
    • Fc
    • FC/His
    • His
    • T7
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human RSPO1-2024H Recombinant Human RSPO1 Protein, His-tagged HEK293 His
    Human RSPO1-001HCL Recombinant Human RSPO1 cell lysate CHO N/A
    Human RSPO1-053H Recombinant Human RSPO1 Protein, Fc-His-tagged HEK293 FC/His
    Human RSPO1-169H Recombinant Human RSPO1 Protein, Biotinylated CHO N/A
    Human RSPO1-1918HCL Recombinant Human RSPO1 cell lysate Human Cell N/A
    Human RSPO1-1942H Recombinant Human RSPO1 protein, His & T7-tagged E.coli His/T7
    Human RSPO1-2341H Recombinant Human RSPO1 protein, His-tagged HEK293 His
    Human RSPO1-265H Recombinant Human RSPO1, His-tagged, Biotinylated HEK293 His
    Human RSPO1-351H Recombinant Human RSPO1, None tagged CHO Fc/His
    Human RSPO1-3872H Recombinant Human RSPO1 protein, His-tagged HEK293 His
    Human RSPO1-670H Recombinant Human RSPO1, Fc-tagged, Biotinylated Human Cell Fc
    Human RSPO1-671H Recombinant Human RSPO1, Fc-tagged Human Cell Fc
    Human RSPO1-8392H Recombinant Human RSPO1 protein CHO N/A
    Mouse RSPO1-001MCL Recombinant Mouse RSPO1 cell lysate CHO N/A
    Mouse Rspo1-054M Recombinant Mouse Rspo1 Protein, Fc-tagged HEK293 Fc
    Mouse Rspo1-1943M Recombinant Mouse Rspo1 protein, His-tagged E.coli His
    Mouse Rspo1-4024M Recombinant Mouse Rspo1, His tagged Human Cell His
    Mouse Rspo1-723M Recombinant Mouse Rspo1, Fc-tagged, Biotinylated Human Cell Fc
    Mouse Rspo1-724M Recombinant Mouse Rspo1, Fc-tagged Human Cell Fc
    Mouse Rspo1-816M Recombinant Mouse Rspo1 CHO N/A
    Mouse Rspo1-8672M Recombinant Mouse Rspo1, His tagged CHO His
    Rat Rspo1-1944R Recombinant Rat Rspo1 protein, His-tagged E.coli His
    Zebrafish RSPO1-499Z Recombinant Zebrafish RSPO1 Mammalian Cell His

    RSPO1 involved in several pathways and played different roles in them. We selected most pathways RSPO1 participated on our site, such as Regulation of FZD by ubiquitination, Signal Transduction, Signaling by Wnt, which may be useful for your reference. Also, other proteins which involved in the same pathway with RSPO1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Regulation of FZD by ubiquitination RSPO1; LGR5; RSPO3; ZNRF3; LGR4; RSPO4; LGR6; FMNL3; RNF43; RSPO2
    Signal Transduction OXGR1; ARHGAP24; LINGO1; KAL1; APOA4B.2; CCBP2; RTKN; BCO2A; RHOT1B; FST
    Signaling by Wnt RYK; HECW1; KREMEN1; RSPO2; RSPO4; LGR5; ROR1; FMNL3; LEO1; TLE3B
    TCF dependent signaling in response to WNT C; LGR4; TLE3B; RSPO4; ASH2L; CBY1; HECW1; DACT1; SOX9B; KLHL12
    Wnt signaling network IGFBP4; RYK; CTHRC1; ATP6AP2; RSPO1; WIF1

    RSPO1 has several biochemical functions, for example, G-protein coupled receptor binding, heparin binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RSPO1 itself. We selected most functions RSPO1 had, and list some proteins which have the same functions with RSPO1. You can find most of the proteins on our site.

    Function Related Protein
    G-protein coupled receptor binding GNAI2; HSPA8; S1PR1; PPY; GNAL; GNA11B; NPFF; PROK2; NPFFL; PICK1
    heparin binding PDCD5; GREM2; CCL5; PF4; THBS2; FGF7; FMODA; CYR61; FMOD; CCL23
    protein binding IPO13; RUFY1; QRICH1; FANCB; SMURF2; EPHB2; HIST2H3C2; PALM; DCP1B; PRPS2
    receptor binding HSD17B4; APOL2; IL1RAPL1; HAMP; MTSS1; RCHY1; EDN3; GUSB; TNFSF9; PVRL3

    RSPO1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RSPO1 here. Most of them are supplied by our site. Hope this information will be useful for your research of RSPO1.

    ZNRF3

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