Active Recombinant Cynomolgus IL1B Protein
Cat.No. : | IL1B-1167C |
Product Overview : | Recombinant mature form of Cynomolgus (Macaca fascicularis) IL1B (Ala 117-Ser 269) was expressed and purified, with an initial Met. |
Availability | February 16, 2025 |
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Source : | E. coli |
Species : | Cynomolgus |
Predicted N Terminal : | Met 1 |
Form : | Lyophilized from sterile PBS, pH 7.4, 5%~8% trehalose and mannitol. |
Bio-activity : | Measured in a cell proliferation assay using D10.G4.1 mouse helper T cells. The ED50 for this effect is typically 3-15 pg/mL. |
Molecular Mass : | The recombinant Cynomolgus IL1B consists of 154 amino acids and has a calculated molecular mass of 17.5 kDa. It migrates as an approximately 18 kDa band in SDS-PAGE under reducing conditions. |
Endotoxin : | < 1.0 EU per μg of the protein as determined by the LAL method. |
Purity : | >97 % as determined by SDS-PAGE. |
Stability : | Samples are stable for up to twelve months from date of receipt at -70ºC. |
Storage : | Store it under sterile conditions at -20ºC~-70ºC. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
Reconstitution : | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.25 ug/ul. Centrifuge the vial at 4℃ before opening to recover the entire contents. |
Tag : | Non |
Protein length : | Ala117-Ser269 |
Gene Name : | IL1B interleukin 1 beta [ Macaca fascicularis ] |
Official Symbol : | IL1B |
Synonyms : | IL-1 beta; Interleukin-1 beta; interleukin 1, beta |
Gene ID : | 102119749 |
mRNA Refseq : | |
Protein Refseq : | |
MIM : | |
UniProt ID : | |
Chromosome Location : | chromosome: 13 |
Pathway : | AGE-RAGE signaling pathway in diabetic complications, organism-specific biosystem; Alzheimer"s disease, conserved biosystem; Amoebiasis, conserved biosystem |
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Customer Reviews (3)
Write a reviewEffective in inflammation studies.
High specificity.
Suitable for cytokine assays.
Q&As (10)
Ask a questionInflammasome assembly initiated by IL-1β is deciphered using techniques like co-immunoprecipitation, proximity ligation assays, and super-resolution microscopy.
IL-1β's priming of immune cells is dissected through flow cytometry, RNA sequencing, and chromatin immunoprecipitation, revealing its epigenetic and transcriptional effects.
Mass spectrometry-based phosphoproteomics deciphers IL-1β's post-translational modifications, revealing regulatory sites crucial for its activation and signaling.
Bioinformatics tools integrate multi-omics data to provide a comprehensive understanding of IL-1β's roles, revealing its intricate contributions to health and disease.
ChIP-seq and DNA methylation profiling uncover IL-1β's epigenetic impact on target genes, shedding light on its role in shaping chronic inflammatory states.
IL-1β's interactions with downstream effectors are unveiled using dual-luciferase reporter assays, surface plasmon resonance, and co-crystallization studies.
Network analysis integrates omics data to unravel IL-1β's intricate cross-talk with other cytokines, mapping out complex regulatory loops in inflammation.
IL-1β's impact on the tumor microenvironment is studied using intravital microscopy, 3D culture models, and single-cell RNA sequencing to capture dynamic cell behavior.
CRISPR-Cas9 screening identifies IL-1β's non-canonical signaling mediators through functional genomics, revealing alternative pathways in cellular responses.
Single-cell RNA sequencing unveils IL-1β's context-specific responses, exposing cell type-specific signaling and gene expression patterns.
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