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Active Recombinant Human CXCL1 Protein (Ala35-Asn107), N-His tagged, Animal-free, Carrier-free

Cat.No. : CXCL1-134H
Product Overview : Recombinant Human CXCL1 Protein (Ala35-Asn107) with N-His tag was expressed in E. coli and Animal-free as well as Carrier-free.
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Description : C-X-C motif chemokine 1 (CXCL1) also named Growth-regulated oncogene alpha (GROα), which is a chemokine of the intercrine alpha family. CXCL1 is a 7.9 kDa protein containing 73 amino acid residues. CXCL1 is expressed in immune cells such as macrophage and neutrophils. CXCL1 plays an important role with immune responses and cancer progression. CXCL1 activates the cell signal transduction with casepas1 that affect the cell proliferation, differentiation and migration.
Source : E. coli
Species : Human
Tag : His
Form : Lyophilized
Bio-activity : Measure by its ability to chemoattract BaF3 cells transfected with human CXCR2. The ED50 for this effect is < 3 ng/mL.
Molecular Mass : The protein has a calculated MW of 8.67 kDa.
The protein migrates as 10 kDa under reducing condition (SDS-PAGE analysis).
Protein length : Ala35-Asn107
Endotoxin : < 0.1 EU/μg of the protein by the LAL method.
Purity : >98% as determined by SDS-PAGE analysis.
Storage : This product is stable after storage at:
-20 centigrade for 12 months in lyophilized state from date of receipt.
-20 or -80 centigrade for 1 month under sterile conditions after reconstitution.
Avoid repeated freeze/thaw cycles.
Storage Buffer : Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
Reconstitution : It is recommended to reconstitute the lyophilized protein in sterile H2O to a concentration not less than 200 μg/mL and incubate the stock solution for at least 20 min to ensure sufficient re-dissolved.
Shipping : The product is shipped with polar packs. Upon receipt, store it immediately at -20 centigrade or lower for long term storage.
Gene Name : CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) [ Homo sapiens (human) ]
Official Symbol : CXCL1
Synonyms : CXCL1; chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha); fibroblast secretory protein , FSP, GRO1, GRO1 oncogene (melanoma growth stimulating activity, alpha) , MGSA; growth-regulated alpha protein; GROa; MGSA a; NAP 3; SCYB1; MGSA alpha; GRO-alpha(1-73); C-X-C motif chemokine 1; fibroblast secretory protein; neutrophil-activating protein 3; melanoma growth stimulatory activity alpha; GRO1 oncogene (melanoma growth-stimulating activity); GRO1 oncogene (melanoma growth stimulating activity, alpha); FSP; GRO1; MGSA; NAP-3; MGSA-a;
Gene ID : 2919
mRNA Refseq : NM_001511
Protein Refseq : NP_001502
MIM : 155730
UniProt ID : P09341

Not For Human Consumption!

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Customer Reviews (3)

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Reviews
06/15/2020

    Efficient delivery, great service.

    01/01/2019

      Product as described, perfect.

      10/13/2018

        Reliable for protein work.

        Q&As (7)

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        Are there any therapeutic strategies targeting CXCL1? 11/17/2022

        Therapeutic strategies targeting CXCL1 aim to modulate its activity in diseases like cancer and chronic inflammation.

        How does CXCL1 contribute to inflammation? 05/03/2022

        It mediates inflammation by promoting leukocyte migration and activation.

        What role does CXCL1 play in tumor progression? 09/30/2021

        In cancer, CXCL1 can promote tumor growth, metastasis, and angiogenesis.

        What is the relationship between CXCL1 and angiogenesis? 04/21/2021

        CXCL1 contributes to angiogenesis, supporting new blood vessel formation.

        What is the primary function of CXCL1 in the immune system? 11/15/2019

        CXCL1 is a chemokine that attracts neutrophils to sites of infection or injury.

        In which pathological conditions is CXCL1 found to be elevated? 08/05/2018

        CXCL1 levels are elevated in conditions like cancer, inflammatory diseases, and infections.

        How is the expression of CXCL1 regulated in cells? 02/06/2018

        CXCL1 expression is regulated by various stimuli, including cytokines and growth factors.

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