Active Recombinant Human FGF-1, Acidic
Cat.No. : | FGF1-2H |
Product Overview : | Recombinant Human FGF-1 protein, expressed in Baculovirus, with N Terminal Met-Phe-Asn-Leu-Pro. |
- Specification
- Gene Information
- Related Products
Description : | Acidic fibroblast growth factor is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological pr centigradeesses, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein functions as a modifier of endothelial cell migration and proliferation, as well as an angiogenic factor. It acts as a mitogen for a variety of mesoderm- and neuroectoderm-derived cells in vitro, thus is thought to be involved in organogenesis. Three alternatively spliced variants encoding different isoforms have been described. The heparin-binding growth factors are angiogenic agents in vivo and are potent mitogens for a variety of cell types in vitro. There are differences in the tissue distribution and concentration of these 2 growth factors. |
Source : | Baculovirus |
Species : | Human |
Predicted N Terminal : | Met-Phe-Asn-Leu-Pro |
Form : | The sterile protein solution (1.8mg/ml) contains 20mM Tris HCl pH=7.9, 100mM KCl, 0.2mM DTT and 20% glycerol. |
Bio-activity : | The ED50 calculated by the dose-dependant proliferation of BAF3 cells expressing FGF receptors (measured by 3H-thymidine uptake) is less then 10 ng/ml, corresponding to a specific activity of 105 Units/mg. |
Molecular Mass : | Fibroblast Growth Factor-1 Human Recombinant (FGF-1) produced in Sf9 insect cells is a single, glycosylated, polypeptide chain containing 140 amino acids and having a molecular mass of 15803 Dalton. The FGF-a is purified by proprietary chromatographic techniques. |
Purity : | Greater than 95.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis bySDS-PAGE. |
Usage : | FOR RESEARCH USE ONLY |
Quality Control Test : | Fibroblast Growth Factor-acidic although stable at 4 centigrade for 3 weeks, should be stored desiccated below -18 centigrade. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). |
Concentration : | 1.8mg/ml |
Warning : | Avoid repeated freeze-thaw cycles. |
Gene Name : | FGF1 fibroblast growth factor 1 (acidic) [ Homo sapiens ] |
Official Symbol : | FGF1 |
Synonyms : | FGF1; fibroblast growth factor 1 (acidic); FGFA; fibroblast growth factor 1; AFGF; ECGF; ECGF beta; ECGFA; ECGFB; endothelial cell growth factor; alpha; beta; FGF alpha; GLIO703; HBGF1; heparin binding growth factor 1; heparin-binding growth factor 1; beta-endothelial cell growth factor; endothelial cell growth factor, beta; endothelial cell growth factor, alpha; FGF-1; HBGF-1; ECGF-beta; FGF-alpha; |
Gene ID : | 2246 |
mRNA Refseq : | NM_000800 |
Protein Refseq : | NP_000791 |
MIM : | 131220 |
UniProt ID : | P05230 |
Chromosome Location : | 5q31.3-q33.2 |
Pathway : | Downstream signaling of activated FGFR, organism-specific biosystem; FGF signaling pathway, organism-specific biosystem; FGFR ligand binding and activation, organism-specific biosystem; FGFR1 ligand binding and activation, organism-specific biosystem; FGFR1b ligand binding and activation, organism-specific biosystem; FGFR1c ligand binding and activation, organism-specific biosystem; FGFR2 ligand binding and activation, organism-specific biosystem; |
Function : | S100 alpha binding; fibroblast growth factor receptor binding; growth factor activity; heparin binding; protein binding; protein tyrosine kinase activity; |
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◆ Native Protein | ||
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◆ Lysates | ||
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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