Active Recombinant Mouse Fgf1 Protein (140 aa)
Cat.No. : | Fgf1-403F |
Product Overview : | Recombinant mouse Fibroblast Growth Factor- acidic (rmFGF-acidic) produced in E. coli is a single non-glycosylated polypeptide chain containing 140 amino acids. A fully biologically active molecule, rmFGF-acidic has a molecular mass of 15.8 kDa analyzed by reducing SDS-PAGE and is obtained by proprietary chromatographic techniques. |
- Specification
- Gene Information
- Related Products
Description : | Fibroblast Growth Factor- acidic (FGF-acidic) is a mitogen targeting at the endothelial cells, and belongs to the heparin binding FGF family, which contains 22 members. FGF-acidic binds to the receptor family FGFR1-4 in vivo with the assistance of heparin. However, along with FGF -basic, FGF-acidic lacks the signal peptide segment, and thus is not secreted via endoplasmic reticulum (ER) and Golgi bodies. Studies have shown that FGF-acidic is highly regulated, and it is a direct angiogenesis factor. If unregulated, angiogenesis could contribute to several diseases including arthritis, diabetes, ocular neovascularization, and especially tumors. Therefore, FGF-acidic is treated as a potential oncogene, and its overexpression is correlated tightly with several cancers. |
Source : | E. coli |
Species : | Mouse |
Form : | Sterile Filtered White lyophilized (freeze-dried) powder. |
Bio-activity : | ED50 < 0.4 ng/mL, measured by a cell proliferation assay using 3T3 cells in the presence of 10 μg/mL heparin, corresponding to a specific activity of > 2.5 × 10^6 units/mg. |
Molecular Mass : | 15.8 kDa, observed by reducing SDS-PAGE. |
Protein Length : | 140 |
AA Sequence : | FNLPLGNYKKPKLLYCSNGGHFLRI LPDGTVDGTRDRSDQHIQLQLSAES AGEVYIKGTETGQYLAMDTEGLLYG SQTPNEECLFLERLEENHYNTYTSK KHAEKNWFVGLKKNGSCKRGPRTHY GQKAILFLPLPVSSD |
Endotoxin : | < 0.2 EU/μg, determined by LAL method. |
Purity : | > 95% by SDS-PAGE and HPLC analyses. |
Storage : | Lyophilized recombinant mouse Fibroblast Growth Factor- acidic (rmFGF-acidic) remains stable up to 6 months at -80 centigrade from date of receipt. Upon reconstitution, rmFGF-acidic should be stable up to 2 weeks at 4 centigrade or up to 3 months at -20 centigrade. |
Storage Buffer : | Lyophilized after extensive dialysis against PBS. |
Reconstitution : | Reconstituted in ddH2O at 100 μg/mL. |
Gene Name : | Fgf1 fibroblast growth factor 1 [ Mus musculus (house mouse) ] |
Official Symbol : | Fgf1 |
Synonyms : | FGF1; fibroblast growth factor 1; AFGF; ECGF; FGFA; ECGFA; ECGFB; FGF-1; HBGF1; HBGF-1; GLIO703; ECGF-beta; FGF-alpha; fibroblast growth factor 1; beta-endothelial cell growth factor; endothelial cell growth factor, alpha; endothelial cell growth factor, beta; fibroblast growth factor 1 (acidic); heparin-binding growth factor 1 |
Gene ID : | 14164 |
mRNA Refseq : | wwwcbilmihov/nuccore/NM_010197 |
Protein Refseq : | wwwcbilmihov/protein/NP_034327 |
UniProt ID : | P10935 |
Products Types
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Fgf1-057M | Active Recombinant Mouse Fgf1 Protein | +Inquiry |
◆ Native Protein | ||
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FGF1-33B | Active Native Bovine FGF1 | +Inquiry |
◆ Lysates | ||
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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