Active Recombinant Human FGF21 Protein, His-tagged

Cat.No. : FGF21-287F
Product Overview : Recombinant Human FGF21 Protein with a His tag was expressed in CHO.
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Description : FGF-21, also known as fibroblast growth factor-21 and FGFL, is a secreted growth factor belonging to theheparin-binding growth factor family. It is produced by hepatocytes in response to fatty acid stimulation. FGF-21 couples with its co-factor beta-Klotho to signal through FGFR1c and FGFR4. Signal transduction results in insulin-independent uptake of glucose by adipocytes. Clinical administration of FGF-21 induces energy expenditure, fat utilization and lipid excretion.
Source : CHO
Species : Human
Tag : His
Form : Sterile Filtered White lyophilized (freeze-dried) powder.
Bio-activity : ED50< 0.3 μg/mL, measured in a bioassay using NIH-3T3 cells.
Molecular Mass : 23-25kDa, observed by reducing SDS-PAGE.
AA Sequence : HPIPDSSPLLQFGGQVRQRYLYTDD AQQTEAHLEIREDGTVGGAADQSPE SLLQLKALKPGVIQILGVKTSRFLC QRPDGALYGSLHFDPEACSFRELLL EDGYNVYQSEAHGLPLHLPGNKSPH RDPAPRGPARFLPLPGLPPALPEPP GILAPQPPDVGSSDPLSMVGPSQGR SPSYASHHHHHH
Endotoxin : < 0.2 EU/μg, determined by LAL method.
Purity : > 95% as analyzed by SDS-PAGE.
Storage : Lyophilized recombinant human FGF-21 remains stable up to 6 months at -80 centigrade from date of receipt. Upon reconstitution, human FGF-21, His should be stable up to 1 week at 4 centigrade or up to 2 months at -20 centigrade.
Storage Buffer : Lyophilized after extensive dialysis against PBS.
Reconstitution : Reconstituted in ddH2O or PBS at 100 μg/mL.
Gene Name : FGF21 fibroblast growth factor 21 [ Homo sapiens ]
Official Symbol : FGF21
Synonyms : FGF21; fibroblast growth factor 21; FGF-21;
Gene ID : 26291
mRNA Refseq : NM_019113
Protein Refseq : NP_061986
MIM : 609436
UniProt ID : Q9NSA1

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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How is FGF21 expression regulated in adipose tissue? 10/31/2022

FGF21 expression in adipose tissue is regulated by various factors, including peroxisome proliferator-activated receptor gamma (PPARγ) activation.

What are the effects of FGF21 on lipid metabolism? 08/27/2020

FGF21 influences lipid metabolism by promoting the utilization of fatty acids for energy, contributing to the regulation of lipid homeostasis.

Can FGF21 be a biomarker for metabolic health? 08/07/2019

FGF21 levels are being explored as potential biomarkers for metabolic health, reflecting conditions such as insulin resistance and metabolic syndrome.

Is FGF21 involved in the regulation of insulin sensitivity? 03/03/2019

Yes, FGF21 plays a role in improving insulin sensitivity, making it a potential target for interventions in insulin resistance-associated conditions.

Does FGF21 have roles in energy expenditure? 11/11/2018

Yes, FGF21 influences energy expenditure by promoting thermogenesis in brown adipose tissue, contributing to overall metabolic regulation.

Are there gender-specific differences in FGF21 levels? 08/30/2017

Gender-specific differences in FGF21 levels have been reported, with some studies suggesting higher circulating FGF21 concentrations in females.

What signaling pathways does FGF21 activate? 01/09/2016

FGF21 activates signaling pathways such as the AMP-activated protein kinase (AMPK) pathway, which contributes to its metabolic effects.

Customer Reviews (3)

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Reviews
01/04/2022

    The manufacturer's history of producing high-quality products contributed to our trust in this protein.

    06/27/2021

      Collaboration with other research groups was made easier by the product's standardized use in the scientific community.

      03/03/2016

        The product's role in promoting collaboration and teamwork positively impacted the quality of our research.

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