Active Recombinant Human IL13 Protein
|Product Overview :||Recombinant Human IL13 Protein without tag was expressed in E. coli.|
- Gene Information
- Related Products
|Description :||Interleukin 13 (IL-13) is a cytokine secreted from type 2 T helper (Th2) cells. IL-13 has overlapping functions with interleukin 4 (IL-4), including the induction of immunoglobulin E (IgE) secretion from B cells, and the inhibition of interleukin 1 beta (IL-1β), tumor necrosis factor alpha (TNF-α), interleukin 8 (IL-8), and interleukin 6 (IL-6) inflammatory cytokine expression. IL-13 also regulates immune cell inflammation in response to the pathophysiological changes of surrounding non-immune cells. The IL-13 receptor consists of the IL-4Ra and IL-13Ra1 subunits. IL-13 can also bind the IL-13Ra2 receptor with high affinity. IL-13 functions are mediated through the JAK/STAT signaling pathway. Human and mouse IL-13 are cross-reactive.|
|Source :||E. coli|
|Bio-activity :||TF-1 cell proliferation, ≤5 ng/mL|
|Molecular Mass :||Monomer, 12.6 kDa (115 aa)|
|AA Sequence :||MSPGPVPPSTALRELIEELVNITQN QKAPLCNGSMVWSINLTAGMYCAAL ESLINVSGCSAIEKTQRMLSGFCPH KVSAGQFSSLHVRDTKIEVAQFVKD LLLHLKKLFREGQFN|
|Endotoxin :||≤1 EUs/μg, Kinetic LAL|
|Purity :||≥95%, Reducing and Non-Reducing SDS PAGE|
|Stability :||12 months from date of receipt when stored at -20 to -80 centigrade as supplied.
1 month when stored at 4 centigrade after reconstituting as directed.
3 months when stored at -20 to -80 centigrade after reconstituting as directed.
|Storage :||Storage Prior to Reconstitution: -20 centigrade|
|Storage Buffer :||Lyophilized from a sterile (0.2 micron) filtered aqueous solution containing 10 mM sodium citrate, pH 3.0|
|Reconstitution :||Sterile 10 mM HCl at 0.1 mg/mL|
|Shipping :||Room temperature|
|Instructions :||Centrifuge vial before opening. Suspend the product by gently pipetting the above recommended solution down the sides of the vial. DO NOT VORTEX. Allow several minutes for complete reconstitution. For prolonged storage, dilute to working aliquots in a 0.1% BSA solution, store at -80 centigrade and avoid repeat freeze thaws.|
|Gene Name :||IL13 interleukin 13 [ Homo sapiens (human) ]|
|Official Symbol :||IL13|
|Synonyms :||IL13; interleukin 13; interleukin-13; allergic rhinitis; ALRH; BHR1; Bronchial hyperresponsiveness 1 (bronchial asthma); IL 13; MGC116786; MGC116788; MGC116789; P600; Bronchial hyperresponsiveness-1 (bronchial asthma); IL-13;|
|Gene ID :||3596|
|mRNA Refseq :||NM_002188|
|Protein Refseq :||NP_002179|
|UniProt ID :||P35225|
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Q&As (10)Ask a question
Flow cytometry quantifies IL13 receptor expression on cells.
Transgenic models illuminate IL13's in vivo functions.
ELISA quantifies IL13 secretion in cell cultures accurately.
siRNA knockdown uncovers IL13's specific cellular effects.
Co-immunoprecipitation identifies IL13 signaling partners.
Differential techniques distinguish IL13 and IL4 signaling pathways.
Reporter gene assays gauge IL13-driven transcription.
Microarray analysis profiles IL13-induced gene expression.
Experimental methods reveal IL13's impact on tissue remodeling.
Site-directed mutagenesis identifies key residues in IL13 receptor binding.
Customer Reviews (3)Write a review
Effective in Th2 cell differentiation. -
Good for cytokine assays. -
High yield in expression. -
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